[ANALYSIS OF ARACHIDONIC ACID RELATIVE CONTENT CHANGES IN ERYTHROCYTES AND PLATELETS PHOSPHOLIPIDS MEMBRANES FEATURES IN CORONARY HEART DISEASE WITH ATRIAL FIBRILLATION PATIENTS].

Erythrocytes and platelets phospholipid membranes fatty acid spectrum was detected in coronary heart disease and atrial fibrillation patients and in patients with coronary heart disease without atrial fibrillation. 87 patients were investigated. Significant decrease in the arachidonic acid relative content in coronary heart disease patients compared with healthy individuals was related. As well as a significant decrease in the arachidonic acid relative content in coronary heart disease and atrial fibrillation patients compared with coronary heart disease patients without atrial fibrillation was related too. These dates may indicate that decreasing relative content arachidonic acid can be possible pathogenetic link in the development of arrhythmias.

Efficacy and tolerability of EPs 7630 tablets in patients with acute bronchitis: a randomised, double-blind, placebo-controlled dose-finding study with a herbal drug preparation from Pelargonium sidoides.

OBJECTIVE: Acute bronchitis is one of the most frequent health complaints for which patients seek medical advice. Although viral infections prevail, antibiotics are commonly prescribed. In this study, the efficacy and tolerability of EPs 7630 tablets, a herbal drug preparation from the roots of Pelargonium sidoides, were investigated in adults with acute bronchitis outside the strict indication for antibiotics. RESEARCH DESIGN AND METHODS: In this randomised, double-blind, placebo-controlled, multicentre dose-finding trial using an adaptive group-sequential design, 406 patients were randomly assigned to one of four parallel treatment groups (10 mg EPs 7630 tablets three times a day (30-mg group), 20 mg EPs 7630 tablets three times a day (60-mg group), 30 mg EPs 7630 tablets three times a day (90-mg group) or placebo three times a day) for a treatment period of 7 days. Primary endpoint was the change in the total score of bronchitis-specific symptoms (BSS) from baseline to day 7. RESULTS: Between day 0 and day 7, the mean BSS score decreased by 2.7 +/- 2.3 (placebo), 4.3 +/- 1.9 (30-mg group), 6.1 +/- 2.1 (60-mg group), and 6.3 +/- 2.0 points (90-mg group), respectively. The differences between the EPs 7630 groups and placebo were statistically significant (p < 0.0001, each). The secondary endpoints showed comparable results. EPs 7630 was well-tolerated. All documented adverse events were of mild to moderate intensity; their frequency was dose-dependent. No serious adverse events were reported. CONCLUSION: This study demonstrated statistically significant and clinically relevant superiority of all three tested dosages of EPs 7630 over placebo. All dosages of EPs 7630 were well-tolerated. Taking into account both efficacy and safety, the results of this study indicate that the 20 mg tablets of EPs 7630 taken three times daily constitute the optimal dose with respect to the benefit-risk ratio.

Particular features of systolic and diastolic functions in patients with metabolic syndrome.

In many epidemiological studies, the relationship between metabolic syndrome and the development of congestive heart failure has been established. Due to the latter, an increased interest has been noticed in scientific studies about the changes in the function of the heart in patients with metabolic syndrome and possible disturbance mechanisms of the pumping function of the heart in this group of patients. In our research, 120 patients with metabolic syndrome and 20 health individuals were studied. The cardiac functions were assessed with the ultrasound imaging machine "Aloka SSD 5000" (Japan) convex sensor of frequency 3.5 MHz with generally used methods. In the course of the experiment, in patients with MS, concentric hypertrophy of the heart and disturbance of the diastolic function of the heart was noticed. Also it was set that there was a significant correlation between the indexes, which in a superlative degree demonstrate abdominal obesity (WHR) and the indexes of LV hypertrophy during diastole (r = 0.72; P < 0.001), LVM (r = 0.81; P < 0.001) and LA (r = 0.63; P < 0.001).

[The effect of alpha-1 adrenergic blockade on the clinical course, immune status and blood plasma lipid spectrum in patients with ischemic heart disease]. / Vliianie al'fa 1-adrenoblokady na klinicheskoe techenie, immunnyi status i lipidnyi spektr plazmy krovi u bol'nykh ishemicheskoi bolezn'iu serdtsa.

Results are submitted of investigations designed to study effects of prazosine on the clinical course, immune and lipid spectrum of blood plasma in IHD patients with functional class I-II middle-aged and elderly-onset exertional angina. Efficiency of prazosine monotherapy was recordable in all FC I-II effort angina patients 30 to 50 years old, which fact was manifested by a decline in the number of angina attacks over the 24-hour period, number and duration of both pain and symptom-free myocardial ischemia, improvement in physical load tolerance. Also recordable in all patients was a positive effect of the drug on blood plasma lipid spectrum and certain immunological indices.

[The clinical characteristics of the course of hypertension in patients with disorders of the rheological properties of the blood]. / Klinicheskie osobennosti techeniia gipertonicheskoi bolezni u bol'nykh s narusheniiami reologicheskikh svoistv krovi.

As many as 185 patients with stage I-III hypertensive disease were examined, their age ranging between 30 and 70 years. Investigation of rheologic properties of blood involved determination of hematocrit value, blood viscosity, aggregation of erythrocytes, platelets, content of fibrinogen, products of fibrin cleavage. It has been ascertained that in patients with stage I hypertensive disease, disorders of rheologic properties of blood are characterised by disturbances in the platelet link of the bloodflow, with the degree being dependent on the cerebral symptomatology; those in patients with stage II hypertensive disease were evidenced by high values for blood viscosity; as to stage III disease complicated by disordered cerebral bloodflow, the degree of rheologic abnormalities may characterize the course and outcome of the disease.

[The role of segmental analgesic mechanisms in the development of silent myocardial ischemia in patients with initial coronary atherosclerosis]. / Rol' segmentarnykh protivobolevykh mekhanizmov v razvitii bezbolevoi ishemii miokarda u bol'nykh s nachal'nym koronarnym aterosklerozom.

In patients with ischemic heart disease (IHD) with early coronary atherosclerosis the ratio of the myocardial ischemia pain episodes (MIPE) to myocardial ischemia pain-free episodes (MIPFE) is 1:4. In IHD patients, an important role to play in the development of MIPFE has the first segmental link in the analgetic system leading to a segmental rise of the electropain sensitivity threshold. Blockade of alpha 1-adrenoreceptors with prazosinum decreases the activity of analgesic mechanisms and favours transition from MIPFE to MIPE. In patients with the initial stages of coronary atherosclerosis, prazosinum promotes a significant alleviation of both MIPFE and MIPE.

The influence of adrenoreactive preparations on clinical and haemodynamic parameters in patients with ischaemic heart disease.

The influence of anaprilin, oxprenolol, nonachlazine, prazosin and levodopa on the clinical course and haemodynamics was investigated in 138 patients with ischaemic heart disease in whom selective coronary angiography had revealed an up to 50 percent stenosis of one of coronary arteries. The clinical picture of IHD patients with a high tolerance of physical exercise was characterized by a preponderance of spontaneous angina pectoris accompanied by painless myocardial ischaemia. A certain role in the genesis of these disturbances is played by the relative increase in the activity of alpha 1-adrenoreceptors and decrease in beta-adrenoreceptor activity. Prazosin and nonachlazine in monotherapy reduced the number of anginal attacks and episodes of painless myocardial ischaemia.

[Cardiohemodynamics and microcirculation in patients with ischemic heart disease undergoing beta-adrenergic receptor stimulation and blockade]. / Kardiogemodinamika i mikrotsirkuliatsiia u bol'nykh ishemicheskoi bolezn'iu serdtsa pri stimuliatsii i blokade beta-adrenergicheskikh retseptorov.

A study of 76 patients with ischemic heart disease is presented who revealed during coronography stenosis of one-three coronary arteries equalling 50-75% of the vessel lumen. Analysis of the effect of anaprilin and nonachlazin on the clinical course and hemodynamics revealed that in patients with initial coronary atherosclerosis of middle age beta-adrenodependent vasodilation of the coronary arteries decreased. In these patients anaprilin may increase the frequency of attacks of spontaneous stenocardia. On the contrary, nonachlazin reduces manifestations of stenocardia but it may be used only in patients with a high tolerance to physical load.

[Clinical and diagnostic features of the initial forms of coronary atherosclerosis]. / Osobennosti kliniki i diagnostiki nachal'nykh form koronarnogo ateroskleroza.

A study is presented of 123 patients with ischemic heart disease showing stenosis of one-two coronary arteries (50% of lumen) and high tolerance to physical load (100 Wt and more). Stenocardia was characterized by development of attacks during rest while average loads were well tolerated by the patients. Pain had a typical location and irradiation, attacks were frequent often provoked by psychoemotional stress and high level of physical load, were controlled by nitroglycerine. It is proposed to call this syndrome "initial stenocardia".

[Characteristics of regional cerebral circulation in parkinsonism patients according the 133Xe clearance findings]. / Kharakteristika regionarnogo mozgovogo krovotoka u bol'nykh parkinsonizmom po dannym klirensa 133XE.

As a rule, in patients with idiopathic parkinsonism the cerebral volume blood flow is decreased in the parietal lobes. Patients with vascular parkinsonism display a decreased blood flow in the frontal and occiptial lobes, more so in the parietal. An inhalation of pure oxygen in the control group of normals decreased the general cerebral blood flow, while in parkinsonic patients it increased it only in the parietal lobes. Treatment with l-dopa regularly and significantly increased the general and regional cerebral blood flow.