1.
Neurochem Res
; 9(2): 219-24, 1984 Feb.
Article
in English
| MEDLINE
| ID: mdl-6330595
ABSTRACT
Many roles have been suggested for N-acetyl-aspartate in brain function because of it being located almost exclusively in that organ. However, its true role remains to be demonstrated. We show here that N-acetyl-aspartate: 1) binds to a hydrophobic protein fraction from the cerebral cortex of the rat, which specifically binds L-aspartate, L-glutamate, and gamma-amino-butyric acid; and 2) has a marked inhibitory effect on the aspartate binding sites of this proteolipid fraction. Structural analogs of N-acetyl-aspartate, i.e. N-carbamyl-aspartate and N-methyl-aspartate also inhibit the L-aspartate binding by the brain protein fraction used.
Subject(s)
Aspartic Acid/analogs & derivatives , Aspartic Acid/antagonists & inhibitors , Cerebral Cortex/metabolism , Proteolipids/metabolism , Animals , Aspartic Acid/metabolism , Aspartic Acid/pharmacology , Cerebral Cortex/drug effects , Cyclic AMP/metabolism , Cyclic GMP/metabolism , Male , N-Methylaspartate , Protein Binding/drug effects , Rats , Rats, Inbred Strains
2.
Physiol Chem Phys
; 14(1): 46, 1982.
Article
in English
| MEDLINE
| ID: mdl-7178243