ABSTRACT
Rituximab is a treatment option to non-Hodg kin's diffuse large B-cell lymphoma (NHDLBCL) in advanced stage and comorbility. It is known the cardiotoxicity effect of this drug, but there is no previous report describing a complete atrioventricular block (CAVB) secundary to treatment with Rituximab. We present an elderly woman treated with monotherapy with Rituximab who experienced a CAVB after administration of the fifth dose of this drug.
Subject(s)
Antibodies, Monoclonal/adverse effects , Antineoplastic Agents/adverse effects , Atrioventricular Block/chemically induced , Lymphoma, Large B-Cell, Diffuse/drug therapy , Aged, 80 and over , Antibodies, Monoclonal, Murine-Derived , Dyslipidemias/complications , Female , Humans , Lymphoma, Large B-Cell, Diffuse/physiopathology , Rituximab , Spinal Osteophytosis/complications , Stroke/complications , Venous Thrombosis/complicationsABSTRACT
A 75-year-old woman was diagnosed of MCD plasma cell (PC) variant with B symptoms. Diffuse lymph-node enlargement, splenomegaly and pancytopenia were detected. Induction with Rituximab was made because pancytopenia was present. Actually patient is free of disease. This is the first complete response of MCD published, VIH negative, induced with anti CD20.
Subject(s)
Antibodies, Monoclonal/therapeutic use , Castleman Disease/drug therapy , Aged , Antibodies, Monoclonal, Murine-Derived , Antigens, CD20 , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Castleman Disease/complications , Castleman Disease/immunology , Female , HIV Seronegativity , Herpesviridae Infections/complications , Herpesvirus 8, Human , Humans , Pancytopenia/complications , Remission Induction , RituximabABSTRACT
We describe the remarkable case of a patient with septicemia caused by Non 0-1 Vibrio Cholerae associated with skin lesion of the lower and upper extremities. This patient suffered from chronic liver disease and a cervix carcinoma in IIIB stage, she had been admitted to the hospital the day before for dicompensated ascites. She received intravenous cefotaxime and had a satisfactory recovery and was completely free of signs and symptoms. We report its epidemiological discovery in inland freshwater and this is the first announced case in Spain with this confirmed environmental isolation and a rare report case in the literature.
Subject(s)
Bacteremia/microbiology , Cholera/microbiology , Immunocompromised Host , Vibrio cholerae/isolation & purification , Aged , Anti-Bacterial Agents/therapeutic use , Bacteremia/drug therapy , Cefotaxime/therapeutic use , Cholera/drug therapy , Female , Humans , Neoplasm Staging , Treatment Outcome , Uterine Cervical Neoplasms/pathologyABSTRACT
Describimos el caso poco frecuente de una paciente con una sepsis por Vibrio Cholerae no 0-1 asociado a lesiones cutáneas en extremidades inferiores y superiores. Esta paciente padecía de una hepatopatía crónica y un carcinoma de cérvix en estadío IIIB y había sido ingresada el día previo por una descompensación ascítica. Su evolución fue buena con resolución completa mediante cefotaxima endovenosa. Destacar sobre todo el hallazgo de su origen epidemiológico, aguas continentales de pozos naturales, siendo esta particularidad la que hace de este caso el primero descrito en España con ese origen demostrado y un caso excepcional en la literatura mundial revisada (AU)
