A ferrobotic system for automated microfluidic logistics.

Automated technologies that can perform massively parallelized and sequential fluidic operations at small length scales can resolve major bottlenecks encountered in various fields, including medical diagnostics, -omics, drug development, and chemical/material synthesis. Inspired by the transformational impact of automated guided vehicle systems on manufacturing, warehousing, and distribution industries, we devised a ferrobotic system that uses a network of individually addressable robots, each performing designated micro-/nanofluid manipulation-based tasks in cooperation with other robots toward a shared objective. The underlying robotic mechanism facilitating fluidic operations was realized by addressable electromagnetic actuation of miniature mobile magnets that exert localized magnetic body forces on aqueous droplets filled with biocompatible magnetic nanoparticles. The contactless and high-strength nature of the actuation mechanism inherently renders it rapid (~10 centimeters/second), repeatable (>10,000 cycles), and robust (>24 hours). The robustness and individual addressability of ferrobots provide a foundation for the deployment of a network of ferrobots to carry out cross-collaborative logistics efficiently. These traits, together with the reconfigurability of the system, were exploited to devise and integrate passive/active advanced functional components (e.g., droplet dispensing, generation, filtering, and merging), enabling versatile system-level functionalities. By applying this ferrobotic system within the framework of a microfluidic architecture, the ferrobots were tasked to work cross-collaboratively toward the quantification of active matrix metallopeptidases (a biomarker for cancer malignancy and inflammation) in human plasma, where various functionalities converged to achieve a fully automated assay.

Attribution Patterns in Men Who Ejaculate Before They Desire: An Internet Survey.

Men with erectile problems tend to attribute negative sexual experiences to themselves, in contrast with sexually functional individuals who tend to attribute negative experiences to external factors such as the circumstance or relationship. In this study, we investigated attribution patterns in men with premature ejaculation (PE) symptoms-a group not yet investigated in this regard-to determine whether they follow patterns similar to men with erectile problems. Using an Internet-based approach, we compared attribution responses of 289 men with PE symptoms with 433 sexually functional men on a series of five sexual scenarios (two presenting a positive experience and three presenting a negative experience). Men with PE symptoms were more likely to take blame for any negative sexual experience, including ones unrelated to ejaculating quickly, whereas functional men were more likely to attribute blame to the partner, circumstance, or relationship. Men with PE symptoms also took less credit for positive sexual experiences than functional counterparts, attributing them to the partner or circumstance. These results point out similarities across men with a variety of sexual problems, but also raise questions regarding differences between men with erectile problems and men with problems of ejaculating before desired. Several therapeutic strategies are offered.