ABSTRACT
The aim of the study was to evaluate the effectiveness of the suture with a coating of triclosan on the dynamics of postoperative course in emergency surgical patients, comparing the postoperative period in the application of the suture with coating and without it. DESIGN: A prospective cohort with a solid retrospective control group. The efficiency of the application of the suture with a coating of triclosan on the flow dynamics in the early postoperative period 678 emergency surgical patients, comparing the postoperative period when using the coated suture material (292 patients) and without (386 patients). EVALUATION CRITERIA: Time of normalization of body temperature and restore the function of the gastrointestinal tract, the duration of hospital treatment, the need for antibiotic prophylaxis and antibiotic therapy, the incidence of postoperative complications (in general and SSI). It was found a statistically significant effect of the application of the suture with triclosan to reduce the incidence of SSI. The economic effect of using SMT is only by reducing the average duration of hospital treatment amounted to 1 723 238 rubles in one year.
Subject(s)
Surgical Procedures, Operative , Surgical Wound Infection , Sutures , Triclosan/pharmacology , Wound Closure Techniques , Adult , Anti-Infective Agents, Local/pharmacology , Coated Materials, Biocompatible/pharmacology , Cohort Studies , Cost-Benefit Analysis , Emergency Medical Services/economics , Emergency Medical Services/methods , Female , Humans , Male , Materials Testing/methods , Middle Aged , Outcome Assessment, Health Care/methods , Prospective Studies , Russia , Surgical Procedures, Operative/adverse effects , Surgical Procedures, Operative/methods , Surgical Wound Infection/economics , Surgical Wound Infection/etiology , Surgical Wound Infection/prevention & control , Treatment Outcome , Wound Closure Techniques/adverse effects , Wound Closure Techniques/economicsABSTRACT
Beta-cyclohexylmethyl-, beta-cyclohexylethyl-, and beta-4-tert-butyl-cyclohexyl glycosides of muramyl dipeptide were shown to increase the resistance of mice to intraperitoneal infection with cultures of Staphylococcus aureus and Escherichia coli. These compounds increased the production of cytokines by mononuclear cells from healthy donors. Beta-cyclohexylethyl glycoside of muramyl dipeptide was more potent than muramyl dipeptide and other derivatives in increasing in vivo antibacterial resistance and in vitro production of interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, and interferon-gamma;. This glycopeptide had a strong stimulatory effect on the production of interleukin-4 and tended to stimulate the synthesis of interferon-alpha. Beta-cyclohexylmethyl glycoside of muramyl dipeptide was most potent in stimulating the production of interleukin-4. Biological activity of beta-4-tert-butyl-cyclohexyl glycoside of muramyl dipeptide was lower than that of other glycosides of muramyl dipeptide.
Subject(s)
Acetylmuramyl-Alanyl-Isoglutamine , Cytokines/immunology , Glycosides , Immunity, Innate/drug effects , Leukocytes, Mononuclear , Acetylmuramyl-Alanyl-Isoglutamine/analogs & derivatives , Acetylmuramyl-Alanyl-Isoglutamine/immunology , Acetylmuramyl-Alanyl-Isoglutamine/pharmacology , Animals , Escherichia coli/drug effects , Escherichia coli Infections/immunology , Glycosides/chemistry , Glycosides/pharmacology , Humans , Leukocytes, Mononuclear/drug effects , Leukocytes, Mononuclear/immunology , Mice , Molecular Structure , Staphylococcal Infections/immunology , Staphylococcus aureus/drug effectsABSTRACT
The incidence of markers of hepatitis C virus (HCV in the blood of 4216 normal subjects living in the European Russia (Northern, North-Western, Central, Central Chernozem, Volga-Vyatka, Volga, and North Caucasian regions), in the Urals, in Siberia (Eastern Siberian region), in the Far East, and in Monogolia is assessed. The incidence of antibodies to HCV varied from 0.7% in the Central region to 3.8% in the Central Chernozem and 10.7% in Mongolia. HCV genotyping (identification of 1a, 1b, 2a, 2b, and 3a genotypes) was performed using 469 RNA of HCV-positive sera of donors and patients collected in Russia, Moldova, Turkmenistan, and Mongolia. The 1b genotype predominated everywhere (68.9%), its incidence being the highest in Moldova (96%). Unclassifiable variants of HCV were found in 28 (6%) of sera. The regularities of HCV genotypes circulation in the European Russia were the same as in other European countries, whereas their prevalence in Eastern Russia was rather like that in China or Japan. The prevalence of genotypes did not depend on the clinical manifestations of diseases caused by HCV.
Subject(s)
Hepacivirus/genetics , Hepatitis C/epidemiology , Adolescent , Adult , Commonwealth of Independent States/epidemiology , Female , Genotype , Hepacivirus/classification , Hepatitis C/virology , Humans , Prevalence , Species SpecificityABSTRACT
Using special brain antigen test-system ELITEST-24, ELISA assays of the serum of children with cerebral palsy were conducted. The data obtained were compared to relevant characteristics of the sera from neurologically and somatically healthy persons and patients with diagnoses of multiple sclerosis, schizophrenia, epilepsy and hepato-cerebral dystrophy according to special PC program VIZUAL and DIAGNOST. High specificity of the cerebral palsy anti-brain antigens reactivity was revealed by ELITEST technique. Moreover, the comparison of the mother-child pair immunoreactivity has been conducted. Evidence for hypothesis of epigenetically performing of children antibodies repertoires by mother-during-pregnancy immune status were obtained. Possible immunopathologic mechanisms of the disease are discussed.
