Antiretroviral therapy in the lives of women of colour with HIV.

Non-adherence to antiretroviral medication is associated with adverse patient outcomes. Considerable research and clinical work has focused on issues surrounding patient compliance to prescribed regimens. Few studies have explored the essence of antiretroviral medications in the lives of women of colour with HIV. A qualitative study of HIV-infected women of colour was undertaken in response to the question: What is the role of antiretroviral medication in your life? Taped interviews were conducted with graduate psychology students and commercially transcribed. Transcriptions were analyzed by Spiegelberg's category-cluster-theme process by four different reviewers. Three themes were distilled: trust/mistrust, approach/avoidance motivation and 'constantly tethered'. Strategies designed to increase medication adherence may need to consider these basic themes in order to be successful.

A case of virilised female with urethral duplication and valve formation.

We report the case of a female (chromosomal 46 XX) with a complex congenital urogenital malformation. Caesarian section was performed at the 30th gestational week due to hydrops fetalis and polyhydramnion. Clinical and radiological evaluation demonstrated a complex urogenital malformation with an enlarged penoclitoral organ, urethral duplication, and concomitant malformations. The girl presented with a female urethra with a vaginal orificium as well as a male urethra culminating in a microphallus. Additionally, a urethral valve formation just cranial to the bifurcation of the male and female urethra was also present. Due to concomitant diseases, a complicated clinical course and recurrent urinary tract infections, the final operative correction resulting in a female phenotype, was performed at the age of 2 (1/2) years as a single-stage procedure.

Nontruncating APC germ-line mutations and mismatch repair deficiency play a minor role in APC mutation-negative polyposis.

Familial adenomatous polyposis, an autosomal-dominantly inherited colorectal cancer predisposition syndrome, is caused by germ-line mutations in the adenomatous polyposis coli (APC) gene. Despite the use of different screening methods, studies worldwide fail to identify APC mutations in 20-50% of all familial adenomatous polyposis patients (APC mutation-negatives). In this study, missense mutations in the coding region of the APC gene, which would have been missed by the protein truncation test, as well as mutations in the APC promoter and the 3' untranslated region, were determined by the single nucleotide polymorphism discovery assay and direct DNA sequencing in 31 mutation-negative polyposis patients. Seventeen gene alterations were identified, whereof four (12.9%) represent possibly pathogenic germ-line mutations: silent A290T (promoter) and A8822G (3' untranslated region) as well as missense R99W and E1317Q (coding region). The 27 remaining, truly APC mutation-negative polyposis patients displayed a significantly later age at diagnosis compared with APC mutation carriers (46.1 versus 35.2 years; P < 0.01). APC mutation-negative individuals with >100 colonic polyps were more likely to present with extracolonic disease (P < 0.05) than those with <100. Assessment of microsatellite instability (MSI), a hallmark of mismatch repair deficiency, in 68 tumors from 21 truly APC mutation-negative patients, identified 4 (5.9%) unstable tubulo-villous adenomas (3 MSI-High and 1 MSI-Low), stemming from 4 (19%) unrelated individuals and likely to be caused by hMLH1 promoter hypermethylation. In conclusion, only a small proportion of APC germ-line mutation carriers is missed by the protein truncation test, and mismatch repair deficiency does not seem to substantially contribute to tumor development in APC mutation-negative polyposis patients.

Reproductive issues in HIV-seropositive women: a survey regarding counseling, contraception, safer sex, and pregnancy choices.

Sixty-nine HIV-seropositive women were surveyed with regard to the reproductive counseling they had received, contraception, safer sex practices, pregnancy histories, and pregnancy plans. Of the women surveyed, 84% and 90%, respectively, felt that they had access to the birth control and safer sex methods of their choice. Less than half felt that their physician had adequately counseled them about birth control. Women primarily cited social workers (46.4%) or nurses (34.8%) as the counseling source for birth control and safer sex. When informed about the reduced risk of vertical transmission with zidovudine (AZT), 33 women indicated that information regarding AZT would affect their future pregnancy decisions. Health care professionals need to be aware of this and counsel patients accordingly.

Ethics, women with HIV, and procreation: implications for nursing practice.

The spread of human immunodeficiency virus (HIV) infection in women of childbearing age has precipitated discussion of the procreative rights of this population. Ethical principles are cited to support both sides of the argument. Implications for nursing care include the need to (1) examine one's own opinion on the issue, (b) assess the context in which the patient is making her decision, (c) share detailed information, and (d) create a supportive environment.

[Symptoms of disease and food allergy in children with Down syndrome]. / Gezondheidsklachten en voedselallergie bij kinderen met het syndroom van Down.

OBJECTIVE: To obtain an impression of how often parents of children with Down's syndrome suspect their children of having a food allergy and what action results from this suspicion. DESIGN: Inventorizing controlled descriptive study. 'Zuid-Holland' in the Netherlands. METHODS: An anonymous questionnaire was sent to 110 parents of children with Down's syndrome and 223 control parents. RESULTS: The parents of children with Down's syndrome reported symptoms of their child which might relate to food allergy more frequently than control parents. They reported more respiratory disease symptoms (62% and 53% respectively; pneumonia: 22% and 3%), more gastrointestinal disease symptoms (28% and 17%; constipation or diarrhoea: 28% and 13%), but fewer skin disease symptoms (12% and 26%). 34% of the parents of Down's syndrome children and 22% of the control parents suspected their child of having an allergy and 13% in both groups suspected food to be the allergenic responsible. Medical and laboratory investigations were performed in 37% and 31% and food allergy was diagnosed in 7% and 31% respectively. No elimination-reïntroduction diet was reported as used for diagnosing. Parents of children with Down's syndrome were less satisfied with their consultation of health workers. All parents in both groups who suspected their children of having a food allergy started an elimination diet, 66% found it had a beneficial effect. CONCLUSION: Compared with control parents, parents of children with Down's syndrome reported symptoms relating to food allergy more frequently, suspected their children of having a food allergy equally often, but had it diagnosed less frequently. However, neither group of parents mentioned that an elimination-provocation test was used for the diagnosis.

Using the PRECEDE model to determine junior high school students' knowledge, attitudes, and beliefs about AIDS.

The effectiveness of a one-period school-based AIDS education program on an adolescent population of seventh and eighth grade students (N = 585) was determined. An instrument based on the PRECEDE model was used to assess program effectiveness. Three-way analysis of variance indicated significant differences (p v .01) between pretest to posttest scores for knowledge, attitude, and beliefs for those who received the program versus those who did not by grade and gender of students. The intervention group scored significantly higher than the comparison group on knowledge gain for both seventh and eighth grade students and for males and females. On attitude items, a significant increase occurred from pretest to posttest for eighth grade students who received the program, but not for seventh grade students. The experimental group of eighth grade students scored higher on the attitudes component than the comparison of eighth grade students on the posttest. When attitudes were examined by gender for females in the educational intervention, an increase occurred in attitude scores from pretest to posttest. While belief scores increased significantly from pretest to posttest for the experimental seventh and eighth grade students, significant increases occurred only for experimental group females. Findings support the contention that a one-class period AIDS education program can affect more than just knowledge since attitudes and beliefs also were partially affected.