ABSTRACT
Hormonal response following a minor physiological stress induced by bleeding in a blood donor clinic was investigated in 134 humans with different blood groups. After venisection, serum cortisol concentration (mean +/- SD) was found highest in blood group A donors (455 +/- 217 nmol/L), followed by group B (364 +/- 206), AB (325 +/- 154) and O (297 +/- 110). In 14 subjects of blood group A compared to an equal number of blood group B subjects, mean plasma adrenaline level was higher in group A (0.23 +/- 0.09 nmol/L) than in group B (0.15 +/- 0.12) but the difference was not statistically significant. Blood group A individuals responded to a stressful situation with higher levels of cortisol, and possibly of adrenaline. These observations tend to support findings of previous studies demonstrating a high risk of diseases related to stress (coronary heart diseases and gastrointestinal diseases), in men with A blood group.
Subject(s)
ABO Blood-Group System , Catecholamines/blood , Hydrocortisone/blood , Stress, Physiological/blood , Adolescent , Adult , Blood Specimen Collection , Epinephrine/blood , Humans , Male , Middle Aged , Norepinephrine/bloodABSTRACT
A simple method for the determination of triodothyronine (T3) uptake using I125-T3 and dextran coated charcoal is described. This reaction is time dependent after the addition of dextran coated charcoal. Effect of temperature, concentrations of I125-T3 and charcoal are reported. Within-run precision has been estimated for normal (CV 4.2%), high (CV 2.7%) and low (CV 6.6%) ranges. Day-to-day precision was similar to within-run precision. Results obtained by this method highly correlate with those obtained using Thyopac-3 reagent kit (Amersham-Searle Laboratories).
