1.
Chem Commun (Camb)
; 50(61): 8324-7, 2014 Aug 07.
Article
in English
| MEDLINE
| ID: mdl-24940819
ABSTRACT
An efficient synthetic route towards tosyl-protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs, has been developed in 5 steps in 54% yield from biomass derived furfural. The synthetic utility of the piperidone core structure was demonstrated with the synthesis of a NK1 receptor antagonist.
Subject(s)
Neurokinin-1 Receptor Antagonists/chemical synthesis , Piperidones/chemical synthesis , Biomass , Crystallography, X-Ray , Furaldehyde/chemistry , Molecular Conformation , Neurokinin-1 Receptor Antagonists/chemistry , Piperidones/chemistry
2.
Aldol reaction under solvent-free conditions: highly stereoselective synthesis of 1,3-amino alcohols
Org Lett
; 2(9): 1291-4, 2000 May 04.
Article
in English
| MEDLINE
| ID: mdl-10810730
ABSTRACT
[formula: see text] A method for the highly stereoselective synthesis of 1,3-amino alcohols based on the indium trichloride-catalyzed Mukaiyama aldol reaction of keto ester (R,S)-1 under solvent-free conditions has been developed. The high selectivity observed can be explained on the basis of the shielding of one face by a remote substituent.