Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Type of study
Language
Publication year range
1.
Endocr Pathol ; 29(3): 294-298, 2018 Sep.
Article in English | MEDLINE | ID: mdl-29766416

ABSTRACT

A 67-year-old man was adrenalectomized due to a tumor measuring 100 mm. Specimens revealed an inflammation with slight fibrosis and moderate infiltrates of lymphocytes and plasmacytes with immunoreactivity for IgG and IgG4 resulting in the diagnosis of an active IgG4-associated adrenalitis. To our knowledge, this is the first reported active adrenalitis of this type. It should be the precursor lesion of the adrenal calcifying fibrous tumor that was reported once before.


Subject(s)
Adrenal Gland Diseases/pathology , Granuloma, Plasma Cell/pathology , Immunoglobulin G4-Related Disease/pathology , Aged , Humans , Immunoglobulin G , Male
2.
Mod Pathol ; 27(6): 899-905, 2014 Jun.
Article in English | MEDLINE | ID: mdl-24232866

ABSTRACT

Cancer testis antigens are encoded by germ line-associated genes that are present in normal germ cells of testis and ovary but not in differentiated tissues. Their expression in various human cancer types has been interpreted as 're-expression' or as intratumoral progenitor cell signature. Cancer testis antigen expression patterns have not yet been studied in germ cell tumorigenesis with specific emphasis on intratubular germ cell neoplasia unclassified as a precursor lesion for testicular germ cell tumors. Immunohistochemistry was used to study MAGEA3, MAGEA4, MAGEC1, GAGE1 and CTAG1B expression in 325 primary testicular germ cell tumors, including 94 mixed germ cell tumors. Seminomatous and non-seminomatous components were separately arranged and evaluated on tissue microarrays. Spermatogonia in the normal testis were positive, whereas intratubular germ cell neoplasia unclassified was negative for all five CT antigens. Cancer testis antigen expression was only found in 3% (CTAG1B), 10% (GAGE1, MAGEA4), 33% (MAGEA3) and 40% (MAGEC1) of classic seminoma but not in non-seminomatous testicular germ cell tumors. In contrast, all spermatocytic seminomas were positive for cancer testis antigens. These data are consistent with a different cell origin in spermatocytic seminoma compared with classic seminoma and support a progression model with loss of cancer testis antigens in early tumorigenesis of testicular germ cell tumors and later re-expression in a subset of seminomas.


Subject(s)
Antigens, Neoplasm/analysis , Antigens, Neoplasm/biosynthesis , Carcinogenesis/metabolism , Neoplasms, Germ Cell and Embryonal/metabolism , Testicular Neoplasms/metabolism , Biomarkers, Tumor/analysis , Humans , Immunohistochemistry , Male , Membrane Proteins/biosynthesis , Neoplasm Proteins/biosynthesis , Neoplasms, Germ Cell and Embryonal/pathology , Testicular Neoplasms/pathology , Tissue Array Analysis
SELECTION OF CITATIONS
SEARCH DETAIL
...