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5.
Phytomedicine ; 13(3): 152-6, 2006 Feb.
Article in English | MEDLINE | ID: mdl-16428021

ABSTRACT

The phytochemical investigation of Trichodesma amplexicaule guided by bioassay, to isolation of triterpenoids and aliphatic phytoconstituents. To evaluate the anti-inflammatory activities of isolated phytoconstituents, models with carrageenan-induced acute arthritis and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats were conducted. The investigated results showed that alkanoic acid significantly inhibited the carrageenan-induced acute arthritis. Moreover, alkane also supressed the development of chronic arthritis induced by CFA. It has been reported that alkane was the major phytoconstituent (1.03 +/- 0.00135%) in in vivo studies.


Subject(s)
Alkanes/pharmacology , Anti-Inflammatory Agents/pharmacology , Arthritis, Experimental/drug therapy , Boraginaceae/chemistry , Triterpenes/pharmacology , Alkanes/chemistry , Alkanes/therapeutic use , Animals , Anti-Inflammatory Agents/therapeutic use , Biological Assay/methods , Disease Models, Animal , Edema/chemically induced , Edema/drug therapy , Freund's Adjuvant/toxicity , Indomethacin/pharmacology , Indomethacin/therapeutic use , Male , Rats , Rats, Wistar , Triterpenes/chemistry , Triterpenes/therapeutic use
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