1.
Zh Nevropatol Psikhiatr Im S S Korsakova
; 86(2): 187-90, 1986.
Article
in Russian
| MEDLINE
| ID: mdl-3518311
ABSTRACT
The authors examined 58 patients with multiple sclerosis and 56 healthy donors. The patients presented elevated production of the migration inhibition factor (MIF) by lymphoid cells to cerebral tissue antigens, most expressed in the acute period of the disease. The blood serum of patients with multiple sclerosis showed inhibitory activity, lymphocytes spontaneously produced the MIF in vitro. Hyperproduction of lymphokins may serve as one of the pathogenetic factors of generalization of the inflammatory process in the central nervous system in patients with multiple sclerosis and indicates impaired regulation of immunity.
Subject(s)
Brain/immunology , Leukocyte Migration-Inhibitory Factors/blood , Leukocytes/immunology , Lymphokines/blood , Multiple Sclerosis/immunology , Cell Movement , Female , Humans , Leukocyte Migration-Inhibitory Factors/biosynthesis , Leukocytes/metabolism , Male , Multiple Sclerosis/blood
2.
Ter Arkh
; 54(12): 113-7, 1982.
Article
in Russian
| MEDLINE
| ID: mdl-6218643