ABSTRACT
The effect of toluene administered into the stomach on amino-containing structures in the spleen of random-bred albino mice was studied. It was shown by Falck-Hillarp method that 6 h after treatment the toxicant stimulated splenic mast cell population and inhibited other amino-containing structures. It is therefore suggested that in control mice the major role in bioamine metabolism in the spleen is played by granular fluorescent cells, while after poisoning, mast cells functioning as adapters acquire the primary role. The levels of catecholamines and serotonin in nervous and nonnervous structures peaked 1 week after poisoning and returned to normal after 4 weeks. Presumably, toluene suppresses the immunity starting from the second week after treatment.
Subject(s)
Catecholamines/metabolism , Serotonin/metabolism , Spleen/drug effects , Spleen/metabolism , Toluene/toxicity , Adrenergic Fibers/drug effects , Adrenergic Fibers/metabolism , Animals , Mast Cells/drug effects , Mast Cells/pathology , Mice , Spleen/immunology , Spleen/pathology , Time FactorsABSTRACT
The authors consider the problem of the express study of new or scantily studied chemical compounds. The data received in short-term experiments allow not only to validate hygienic standards but also to evaluate the character of action of chemicals studied. The authors discuss the possibility of rejecting the determination of Lim(ac) in practice of validating Tentative Safe Exposure Levels in working zone air (TSELwz).
