ABSTRACT
The general pattern of local inflammation in the rat is developed in the pad of the paw. In otorhinolaryngology a model of local inflammation can be reached in the rat ear by means of the production of an auricular chondritis. For that, we have protocolized the methodology. The induction of inflammation is carried out by the substance vegetable carrageenan. It has been verified by histological studies the inflammation generated, as well as studying the action of antiinflammatory, proinflammatory and inflammatory compounds. The inflammation has been measured by nonius and by determination of the activity of the myeloperoxidase enzyme. After these studies we can validate the auricular chondritis in rat as an experimental model of local inflammation in otorhinolaryngology.
Subject(s)
Cartilage/pathology , Ear, External/pathology , Inflammation/pathology , Animals , Cartilage/metabolism , Disease Models, Animal , Ear Diseases/metabolism , Ear Diseases/pathology , Ear, External/metabolism , Female , Inflammation/metabolism , Rats , Rats, Wistar , Vasoactive Intestinal Peptide/metabolismSubject(s)
Brain Diseases/parasitology , Echinococcosis/diagnostic imaging , Tomography, X-Ray Computed , Adult , Brain Diseases/complications , Brain Diseases/diagnostic imaging , Brain Diseases/therapy , Brain Injuries/complications , Combined Modality Therapy , Diagnosis, Differential , Disease Susceptibility , Echinococcosis/complications , Echinococcosis/epidemiology , Echinococcosis/therapy , Humans , Male , Prevalence , Rural HealthABSTRACT
The clinicopathological and ultrastructural features of seven Malignant Fibrous Histiocytomas reported to the Spanish Registry of Bone Tumors were studied. Two patients were females (20 and 60 years old) and the other five males (15, 37, 67, 38 and 17 years old). The tumors were located in the lower femur (3 cases), upper tibia, upper humerus, rib and iliac bone. The past medical history revealed previous fracture in one patient and previous radiation of the affected bone in another; in a third patient the tumor associated to a bone infarct. Microscopically all tumors presented a storiform pattern composed of neoplastic fibroblasts, histiocytes, and malignant multinucleated giant cells. There was no evidence of osteoid or bone tissue formation by the tumor cells. Five cases were studied with electronmicroscopy; the tumor cells had features of fibroblasts, myofibroblasts, histiocytes and multinucleated histiocytes. Primary and secondary lysosomes, along with lipid vacuoles were common findings in the tumor cells. The value of the electron-microscopy in the differential diagnosis of this tumor is emphasized.
