Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Seizure ; 1(4): 281-9, 1992 Dec.
Article in English | MEDLINE | ID: mdl-1344778

ABSTRACT

We have studied 124 children with typical absence epilepsy. The onset of symptoms was in 12% under 4 years, in 51% between 4-8 years and in 37% above 8 years. The F:M ratio was 2:1 in children under 4 years versus 1:1 above 8 years. Absences alone occurred in 82% and absences followed or preceded by generalized tonic-clonic seizures (GTCS) in 6.5% and 11%, respectively. Simple absences were not seen in children under 4 years and were more frequent (14%) in the 4-8 years age group. Family history was positive for epilepsy in 20% and febrile convulsion in 7%. Sixteen percent had a positive past history of febrile convulsions. All patients showed bilateral, synchronous spike-wave discharges from 2.5 to 4 c/s. Lateralized spikes, spike-slow wave complexes were found in 27%. Photosensitivity was present in 18% and was marked in 12%. Monotherapy with sodium valproate or ethosuximide (91% SV) was successful in 85% of patients with absences alone and 68% of the absences with GTCS. Only 2% were not fully controlled either on monotherapy or polytherapy. Treatment was withdrawn in 41 patients and 13 relapsed. We have identified four factors associated with relapses: (a) poor initial response to treatment, (b) lateralized focal EEG abnormality and/or marked photosensitivity, (c) the evolution to myoclonic epilepsy, and (d) early withdrawal of AED (< 3 years).


Subject(s)
Epilepsy, Absence/diagnosis , Epilepsy, Tonic-Clonic/diagnosis , Adolescent , Child , Child, Preschool , Drug Therapy, Combination , Educational Status , Electroencephalography/drug effects , Epilepsy, Absence/drug therapy , Epilepsy, Absence/genetics , Epilepsy, Tonic-Clonic/drug therapy , Epilepsy, Tonic-Clonic/genetics , Female , Humans , Male , Prognosis , Recurrence , Risk Factors , Seizures, Febrile/diagnosis , Seizures, Febrile/drug therapy , Seizures, Febrile/genetics
SELECTION OF CITATIONS
SEARCH DETAIL
...