ABSTRACT
The authors described methods of cervical cancer therapy performed in 1970 using the proton beam of the Institute of Theoretical and Experimental Physics and analyzed long-term results. The use of protons resulted in homogeneous irradiation of a preset target volume without injuring the adjacent organs and tissues. Proton beam irradiation of the uterus was combined with gamma-beam therapy of the zones of regional metastatic spreading. Postradiation reactions were unobserved in the adjacent bladder and rectum in patients receiving combined therapy and irradiation alone. The clinical efficacy of proton beam irradiation was confirmed by the treatment of 160 patients.
Subject(s)
Protons , Uterine Cervical Neoplasms/radiotherapy , Combined Modality Therapy , Female , Follow-Up Studies , Gamma Rays/therapeutic use , Humans , Lymphatic Metastasis , Particle Accelerators , Preoperative Care , Radiation Injuries/epidemiology , Radiotherapy Dosage , Uterine Cervical Neoplasms/mortalitySubject(s)
Neoplasms/radiotherapy , Particle Accelerators , Protons , Radiotherapy, High-Energy/instrumentation , Acromegaly/etiology , Adenoma/complications , Adenoma/radiotherapy , Adult , Aged , Amenorrhea/etiology , Cushing Syndrome/etiology , Eye Neoplasms/radiotherapy , Female , Follow-Up Studies , Humans , Male , Melanoma/radiotherapy , Middle Aged , Pituitary Irradiation , Pituitary Neoplasms/complications , Pituitary Neoplasms/radiotherapy , Radiotherapy Dosage , Uveal Neoplasms/radiotherapyABSTRACT
Rats were irradiated laterally through the brain with 200 MeV protons. The beam was of circular cross-section with a diameter of 5 or 7 mm. The doses were 50, 70, 100 and 150 Gy. After irradiation the rats were examined several times by use of injected 99Tcm-pertechnetate. The uptake of the substance increased to a maximum after 20 to 30 days and then decreased to a normal level. Differences in maximum uptake with respect to dose were significant only for the smaller beam diameter.
