Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 3 de 3
Filter
Add more filters










Publication year range
1.
Mycoses ; 66(3): 219-225, 2023 Mar.
Article in English | MEDLINE | ID: mdl-36380646

ABSTRACT

BACKGROUND: Since February 2021 active screening of COVID-19-associated pulmonary aspergillosis (CAPA) has been implemented in our institution. OBJECTIVES: To evaluate CAPA incidence in our centre and evaluate performance of our screening protocol. METHODS: We screened once per week, collecting endotracheal aspirates for fungal culture and galactomannan (GM) and serum for 1,3-ß-D-glucan (BG). In case of positivity (GM more than 4.5, platelia assay, and/or BG >7 pg/ml, wako and/or positive fungal culture), second-level investigations were performed to pursue CAPA diagnosis according to ECMM/ISHAM criteria: bronchoalveolar lavage (BAL) fungal culture and GM, chest computed tomography (CT), serum GM. RESULTS: A total of 102 patients were screened (median age 64 years, range 39-79; 28 (27.4%) females). Twenty-two patients were diagnosed with CAPA (21%). 12 patients were positive for serum BG, 17 patients were positive for endotracheal aspirates GM and 27 patients were positive for endotracheal aspirates fungal culture. Thirty-two BALs were performed, and 26 patients underwent CT chest. Following the second level investigations 61% of the patients with positive screening tests were diagnosed with CAPA. Serum BG above 20 pg/ml or positive serum GM were always associated with typical CT chest signs of aspergillosis. Compared with 1 single positive test, having 2 positive screening test was significantly more associated with CAPA diagnosis (p = .0004). CONCLUSIONS: Active CAPA screening with serum 1,3-ß-D-glucan and endotracheal aspirates galactomannan and fungal cultures and consequent second level investigations led to high number of CAPA diagnosis. Combining more positive fungal biomarkers was more predictive of CAPA diagnosis.


Subject(s)
COVID-19 , Invasive Pulmonary Aspergillosis , Pulmonary Aspergillosis , beta-Glucans , Female , Humans , Adult , Middle Aged , Aged , Male , Invasive Pulmonary Aspergillosis/diagnosis , Invasive Pulmonary Aspergillosis/complications , COVID-19/complications , Pulmonary Aspergillosis/diagnosis , Pulmonary Aspergillosis/complications , Mannans , Bronchoalveolar Lavage Fluid/microbiology , Sensitivity and Specificity
2.
Am J Emerg Med ; 27(9): 1176.e1-3, 2009 Nov.
Article in English | MEDLINE | ID: mdl-19931793

ABSTRACT

We report on a patient with coagulation abnormalities induced by a wasp sting anaphylaxis. First, we observed an unclottable activated partial thromboplastin time and a significant anti-Xa activity (equivalent to a therapeutic heparin range), whereas the patient had received no heparin. This phenomenon is probably due to activated mast cells that release mediators such as heparin and tryptase. Heparin can then act as an anticoagulant by binding to antithrombin. This "heparinization" explains the anti-Xa activity contributing to the unclottable activated partial thromboplastin time detected in our patient. Second, we noted an extremely low fibrinogen level in the presence of normal platelet count and only a slight increase of D-dimers (absence of important disseminated intravascular coagulation). This is probably due to serum tryptase released during massive mast cell activation. Tryptase cleaves the alpha and beta chains of fibrinogen. This results in the removal of the thrombin cleavage site and of the critical polymerization site from the fibrinogen beta chain. Thrombin- initiated clot formation is therefore inhibited. Tryptase also acts directly on the fibrinolytic pathway by activating the single-chain urinary-type plasminogen activator, resulting in conversion of plasminogen into plasmin and therefore degradation of fibrinogen and other coagulation factors. This hyperfibrinogenolysis explains both the prolonged clotting times and the low fibrinogen level observed. Although our patient did not bleed, in other settings (trauma, during surgery) patients with anaphylaxis may present bleeding disorders. Although the mechanisms underlying these abnormalities have been described in vitro and in vivo animal trials, this is the first time they are described in a human clinical setting.


Subject(s)
Anaphylaxis/complications , Anaphylaxis/diagnosis , Blood Coagulation Disorders/diagnosis , Blood Coagulation Disorders/etiology , Insect Bites and Stings/complications , Wasps , Anaphylaxis/therapy , Animals , Blood Coagulation Disorders/therapy , Female , Fibrinolysis , Humans , Insect Bites and Stings/diagnosis , Insect Bites and Stings/therapy , Young Adult
3.
Rev. esp. cardiol. (Ed. impr.) ; 53(12): 1583-1588, dic. 2000.
Article in Es | IBECS | ID: ibc-2713

ABSTRACT

Introducción. El valor pronóstico, durante un infarto de miocardio, de las enzimas, la evolución del segmento ST y las arritmias de reperfusión permanece en discusión. Objetivo. Nuestro objetivo fue relacionar los picos precoces enzimáticos, la evolución del segmento ST y las 'arritmias de reperfusión' después de terapia trombolítica con la angina postinfarto, el índice de Killip y la mortalidad del infarto de miocardio durante su fase precoz. Pacientes y métodos. Sobre 187 pacientes que recibieron fibrinolíticos de forma consecutiva y prospectiva se incluyeron 169. Se determinaron las enzimas miocárdicas CK, MB, TGO, LDH y se realizó electrocardiograma antes y a las 2, 6, 12 y 24 h de administrar el fibrinolítico. Resultados. La edad fue de 60,12 ñ11,3 años, 138 (81,7 por ciento) pacientes eran varones y el infarto fue anterior en 74 (43,7 por ciento) e inferior en 95 (56,3 por ciento). Presentaron arritmias de reperfusión 65 enfermos (38,5 por ciento), 131 (77,5 por ciento) se encontraban en clase Killip I, 12 (7,1 por ciento) presentaron angina postinfarto y ocho fallecieron (4,7 por ciento).No existió correlación estadísticamente significativa entre los picos enzimáticos, las arritmias de reperfusión, el índice de Killip, la angina postinfarto ni la mortalidad precoz. A mayor sumatoria del segmento ST, mayor gravedad según el índice de Killip. En el análisis de regresión logística no se pudo ajustar ningún modelo relacionado con la angina postinfarto, sólo la edad se relacionó con la mortalidad y el sexo, y la edad con la insuficiencia cardíaca. Conclusiones. En nuestra población las variables estudiadas no han sido de utilidad para estimar un pronóstico en los primeros momentos de un infarto agudo de miocardio (AU)


Subject(s)
Middle Aged , Aged , Male , Female , Humans , Thrombolytic Therapy , Myocardial Reperfusion Injury , Critical Care , Myocardial Infarction , Myocardium , Prospective Studies
SELECTION OF CITATIONS
SEARCH DETAIL
...