Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters











Database
Language
Publication year range
1.
Cereb Cortex ; 28(8): 2775-2785, 2018 08 01.
Article in English | MEDLINE | ID: mdl-28655157

ABSTRACT

Sleep problems relate to brain changes in aging and disease, but the mechanisms are unknown. Studies suggest a relationship between ß-amyloid (Aß) accumulation and sleep, which is likely augmented by interactions with multiple variables. Here, we tested how different cerebrospinal fluid (CSF) biomarkers for brain pathophysiology, brain atrophy, memory function, and depressive symptoms predicted self-reported sleep patterns in 91 cognitively healthy older adults over a 3-year period. The results showed that CSF levels of total- and phosphorylated (P) tau, and YKL-40-a marker of neuroinflammation/astroglial activation-predicted poor sleep in Aß positive older adults. Interestingly, although brain atrophy was strongly predictive of poor sleep, the relationships between CSF biomarkers and sleep were completely independent of atrophy. A joint analysis showed that unique variance in sleep was explained by P-tau and the P-tau × Aß interaction, memory function, depressive symptoms, and brain atrophy. The results demonstrate that sleep relates to a range of different pathophysiological processes, underscoring the importance of understanding its impact on neurocognitive changes in aging and people with increased risk of Alzheimer's disease.


Subject(s)
Aging/cerebrospinal fluid , Amyloid beta-Peptides/cerebrospinal fluid , Brain/pathology , Encephalitis/cerebrospinal fluid , Sleep Wake Disorders/cerebrospinal fluid , tau Proteins/cerebrospinal fluid , Aged , Aged, 80 and over , Apolipoproteins E/genetics , Atrophy/cerebrospinal fluid , Atrophy/pathology , Brain/diagnostic imaging , Chitinase-3-Like Protein 1/cerebrospinal fluid , Encephalitis/diagnostic imaging , Female , Follow-Up Studies , Humans , Magnetic Resonance Imaging , Male , Mental Status Schedule , Middle Aged , Neurofilament Proteins/cerebrospinal fluid , Sleep Wake Disorders/diagnostic imaging
SELECTION OF CITATIONS
SEARCH DETAIL