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Prevalence of macrolide resistance genes in clinical isolates of the Streptococcus anginosus ("S. milleri") group.

Jacobs, J A; van Baar, G J; London, N H; Tjhie, J H; Schouls, L M; Stobberingh, E E.

Antimicrob Agents Chemother ; 45(8): 2375-7, 2001 Aug.

Article in English | MEDLINE | ID: mdl-11451701

ABSTRACT

Twenty-two unrelated erythromycin-resistant anginosus group strains (3.2% resistance rate) were assessed for mechanisms of resistance. Streptococcus anginosus accounted for 16 of the 22 isolates. Fifteen isolates harbored the erm(B) gene. The erm(TR) and the mef(E) genes were carried by two isolates each. In three isolates, none of these resistance genes was detected by PCR.

Subject(s)

Anti-Bacterial Agents/pharmacology , Genes, Bacterial/genetics , Streptococcus/genetics , Clindamycin/pharmacology , DNA, Bacterial/analysis , Drug Resistance, Microbial/genetics , Erythromycin/pharmacology , Humans , Methyltransferases/genetics , Polymerase Chain Reaction , Prevalence , Streptococcus/drug effects

High prevalence of colonization with vancomycin- and pristinamycin-resistant enterococci in healthy humans and pigs in The Netherlands: is the addition of antibiotics to animal feeds to blame?

van den Bogaard, A E; Mertens, P; London, N H; Stobberingh, E E.

J Antimicrob Chemother ; 40(3): 454-6, 1997 Sep.

Article in English | MEDLINE | ID: mdl-9338505

Subject(s)

Animal Feed , Enterococcus/drug effects , Vancomycin/pharmacology , Virginiamycin/pharmacology , Animals , Drug Resistance, Microbial , Feces/microbiology , Humans , Microbial Sensitivity Tests , Netherlands

Treating acute urinary tract infections. An RCT of 3-day versus 7-day norfloxacin.

Trienekens, T A; London, N H; Houben, A W; De Jong, R A; Stobberingh, E E.

Can Fam Physician ; 39: 514-8, 1993 Mar.

Article in English | MEDLINE | ID: mdl-8471899

ABSTRACT

A randomized, controlled trial was carried out to compare two courses of treatment in women with acute urinary tract infection in general practice. The 3-day course of treatment was found to be as effective as, and cheaper than, the 7-day therapy.

Subject(s)

Norfloxacin/therapeutic use , Urinary Tract Infections/drug therapy , Absenteeism , Acute Disease , Adolescent , Adult , Aged , Double-Blind Method , Escherichia coli Infections/drug therapy , Female , Humans , Middle Aged , Norfloxacin/administration & dosage , Norfloxacin/adverse effects , Norfloxacin/economics , Patient Compliance , Placebos , Recurrence , Time Factors

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