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1.
Ultrasonics ; 108: 106215, 2020 Dec.
Article in English | MEDLINE | ID: mdl-32835998

ABSTRACT

A modelling framework for ultrasonic inspection of waveguides with arbitrary discontinuities, excited using piezoelectric transducers, is developed. The framework accounts for multi-modal, dispersive and damped one dimensional propagation over long distances. The proposed model is applied to simulate a realistic guided wave-based inspection of a welded rail. The framework models the excitation, propagation and scattering of guided waves from welds by respectively employing a hybrid model that couples a 3D FEM model of a piezoelectric transducer with a 2D SAFE model of the rail; a 2D SAFE model of the rail; and another hybrid method which couples a 3D FEM model of the arbitrary discontinuity (weld) with two SAFE models of the rail to represent the semi-infinite incoming and outgoing waveguides. Optimal damping parameters for hysteretic and viscous damping, respectively, are determined using a model updating procedure to approximate attenuation in the rail. Good agreement between the experimental measurement and simulation is demonstrated, even for weld reflections originating over 640 m from the transducer location. The proposed physics-based framework can be used to efficiently perform multiple analyses considering different numbers and locations of welds, different excitation signals or to investigate the effects of changes in parameters such as transducer geometry, or material property variations caused by temperature fluctuations. The framework could therefore be used in future to set up a digital twin of a section of rail track, or in the development of a rail monitoring system by predicting reflections from defects which cannot readily be measured, but which can be simulated.

2.
Arthritis Care Res (Hoboken) ; 72(11): 1636-1644, 2020 11.
Article in English | MEDLINE | ID: mdl-31478597

ABSTRACT

OBJECTIVE: Dermatomyositis (DM) has been associated with geospatial differences in ultraviolet (UV) radiation, but the role of individual determinants of UV exposure prior to diagnosis is unknown. The objective was to examine the role of those individual determinants. METHODS: We analyzed questionnaire data from 1,350 adults in a US national myositis registry (638 with DM, 422 with polymyositis [PM], and 290 with inclusion body myositis [IBM] diagnosed at ages 18-65 years), examining the likelihood of DM compared with PM and IBM diagnosis, in relation to self-reported sunburn history and job- and hobby-related sun exposures in the year prior to diagnosis. We estimated odds ratios (ORs) and 95% confidence intervals (95% CIs) using logistic regression adjusted for age, skin tone, and sex, to determine the association of individual UV exposures with DM diagnosis. We also evaluated the proportion of DM by maximum daily ambient UV exposure, based on UVB erythemal irradiances for participant residence in the year prior to diagnosis. RESULTS: DM was associated with sunburn in the year before diagnosis (2 or more sunburns OR 1.77 [95% CI 1.28-2.43] versus PM/IBM; 1 sunburn OR 1.44 [95% CI 1.06-1.95]) and with having elevated job- or hobby-related sun exposure (high exposure OR 1.64 [95% CI 1.08-2.49] or moderate exposure OR 1.35 [95% CI 1.02-1.78] versus low or no exposure). Ambient UV intensity was associated with DM in females (ß = 3.97, P = 0.046), but not overall. CONCLUSION: Our findings suggest that high or moderate personal exposure to intense sunlight is associated with developing DM compared with other types of myositis. Prospective research on UV exposure as a modifiable risk factor for DM is warranted.


Subject(s)
Dermatomyositis/etiology , Myositis, Inclusion Body/etiology , Polymyositis/etiology , Radiation Exposure/adverse effects , Ultraviolet Rays/adverse effects , Adolescent , Adult , Aged , Dermatomyositis/epidemiology , Female , Humans , Male , Middle Aged , Myositis, Inclusion Body/epidemiology , Polymyositis/epidemiology , Registries , Spatial Analysis , Sunburn/complications , Surveys and Questionnaires , United States/epidemiology , Young Adult
3.
Arthritis Care Res (Hoboken) ; 71(12): 1600-1605, 2019 12.
Article in English | MEDLINE | ID: mdl-30714338

ABSTRACT

OBJECTIVE: Ultraviolet (UV) radiation is considered to be an important environmental factor in the clinical course of children with juvenile dermatomyositis (DM). We aimed to evaluate the association between UV radiation and severe disease outcomes in juvenile DM. METHODS: This is a cross-sectional study of patients with juvenile DM enrolled in the US multicenter Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry from 2010 to 2015. The mean UV index (UVI) in the calendar month prior to symptom onset in each subject's zip code was calculated from daily satellite solar noon measurements. Multivariable logistic regression was used to model the relationship between the mean UVI and calcinosis as well as other outcomes of severe disease. Covariates included sex, race, age, time to diagnosis, disease duration, and latitude. RESULTS: In a multivariable model, there was no association between the mean UVI and calcinosis. African American race was associated with a 3-fold greater odds of calcinosis. However, there was a significant statistical interaction between race and mean UVI. Accounting for this interaction, the odds of calcinosis markedly decreased in African American subjects and steadily increased in non-African American subjects over a range of increasing the mean UVI. Higher mean UVI was associated with decreased odds of using biologics or nonmethotrexate disease-modifying antirheumatic drugs and skin ulceration. CONCLUSION: We described a novel association between UV radiation, calcinosis, and race in a large cohort of patients with juvenile DM. This study furthers our knowledge of the role of UV radiation in the clinical course of juvenile DM and highlights the complex interplay between genes and environment in the clinical phenotypes and development of calcinosis in children with juvenile DM.


Subject(s)
Dermatomyositis/diagnosis , Environmental Exposure/adverse effects , Registries , Skin/radiation effects , Ultraviolet Rays/adverse effects , Calcinosis/diagnosis , Calcinosis/ethnology , Calcinosis/etiology , Child , Child, Preschool , Cross-Sectional Studies , Dermatomyositis/ethnology , Disease Progression , Female , Follow-Up Studies , Humans , Incidence , Male , Prognosis , Retrospective Studies , Rheumatology , Risk Factors , Severity of Illness Index , Skin/pathology , United States/epidemiology
4.
Ultrasonics ; 96: 240-252, 2019 Jul.
Article in English | MEDLINE | ID: mdl-30685066

ABSTRACT

Guided wave based monitoring systems require accurate knowledge of mode propagation characteristics such as wavenumber and group velocity dispersion curves. These characteristics may be computed numerically for a rail provided that the material and geometric properties of the rail are known. Generally, the rail properties are not known with sufficient accuracy and these properties also change due to temperature, rail wear and rail grinding. An automated procedure is proposed to estimate material and geometric properties of a rail by finding the properties which, when input into a Semi-Analytical Finite Element (SAFE) model, accurately reproduce measured dispersion characteristics. Pulse-echo measurements were performed and spectrograms show the reflections from aluminothermic welds of three modes of propagation. The SAFE method was used to solve the forward problem of predicting the dispersion characteristics for specified rail properties. Dispersion curves are computed for different combinations of Poisson's ratio and three geometric parameters. These dispersion curves are scaled to cover a range of longitudinal speeds of sound of the rail material. A technique is developed to determine which SAFE model provided the best fit to the experimental measurements. The technique does not require knowledge of the distances to the reflectors; rather these distances are estimated as part of the proposed procedure. A SAFE model with the estimated rail parameters produced dispersion curves and distances in very good agreement with the measured spectrograms. In addition, the estimated mean geometric parameters agreed with the measured profile of the rail head.

5.
Ultrasonics ; 84: 341-349, 2018 Mar.
Article in English | MEDLINE | ID: mdl-29232590

ABSTRACT

Accurate computation of dispersion characteristics of guided waves in rails is important during the development of inspection and monitoring systems. Wavenumber versus frequency curves computed by the semi-analytical finite element method exhibit mode repulsion and mode crossing which can be difficult to distinguish. Eigenvalue derivatives, with respect to the wavenumber, are used to investigate these regions. A term causing repulsion between two modes is identified and a condition for two modes to cross is established. In symmetric rail profiles the mode shapes are either symmetric or antisymmetric. Symmetric and antisymmetric modes can cross each other while the modes within the symmetric and antisymmetric families do not appear to cross. The modes can therefore be numbered in the same way that Lamb waves in plates are numbered, making it easier to communicate results. The derivative of the eigenvectors with respect to wavenumber contains the same repulsion term and shows how the mode shapes swop during a repulsion. The introduction of even a small asymmetry appears to lead to repulsion forces that prevent any mode crossings. Measurements on a continuously welded rail track were performed to illustrate a mode repulsion.

6.
Ultrasonics ; 57: 209-17, 2015 Mar.
Article in English | MEDLINE | ID: mdl-25497003

ABSTRACT

The ability to measure the individual modes of propagation is very beneficial during the development of guided wave ultrasound based rail monitoring systems. Scanning laser vibrometers can measure the displacement at a number of measurement points on the surface of the rail track. A technique for estimating the amplitude of the individual modes of propagation from these measurements is presented and applied to laboratory and field measurements. The method uses modal data from a semi-analytical finite element model of the rail and has been applied at frequencies where more than twenty propagating modes exist. It was possible to measure individual modes of propagation at a distance of 400 m from an ultrasonic transducer excited at 30 kHz on operational rail track and to identify the modes that are capable of propagating large distances.

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