ABSTRACT
A case of sarcoma botryoides of the vagina in a 15-month old child with a survival of ten years is described. The authors review the clinical and histological characteristics of the neoplasm and the different therapeutic measures employed. They conclude that a multidisciplinary treatment is needed, consisting of surgical removal, combined radiotherapy with intracavitary radium and cobalt 60, and antineoplastic multidrug chemotherapy.
Subject(s)
Rhabdomyosarcoma/pathology , Vaginal Neoplasms/pathology , Brachytherapy , Female , Follow-Up Studies , Humans , Infant , Rhabdomyosarcoma/radiotherapy , Rhabdomyosarcoma/surgery , Time Factors , Vaginal Neoplasms/radiotherapy , Vaginal Neoplasms/surgeryABSTRACT
La irradiación del ebdomen en los niños, que forma parte del plan terapéutico multidisciplinario de distintas neoplasias malignas, lleva implícita la aparición de enteritis radiógena. En un grupo de 63 pacientes tratados en el Instituto de Oncología y Radiobiología, en Ciudad de La Habana, por presentar linfomas no hodgkinianos de localización intrabdominal, tumores de Wilms, neuroblastomas, sarcomas intrabdominales y neoplasias malignas del ovario, la incidencia de esta complicación fue del 63,5 porciento; en 34 niños apareció en el transcurso del tratamiento radiante (enteritis temprana) y en 11, después de terminado (enteritis tardía). La cirugía exerética amplia contribuyó a la aparición del cuadro. El tratamiento higiénico-dietético mejora la evolución clínica en los pacientes (AU)
Subject(s)
EnteritisABSTRACT
A retrospective study of 85 children with non-Hodgkin' s lymphoma diagnosed and treated in the period of 1963-1974 was undertaken to asses clinical characteristics, pronostic factors and survival. This malignancy was more frequent in males between ages 3 and 4. The histopathologic diagnosis revealed a lymphosarcoma lymphoblastic predominance (77.6%). The clinical extent at diagnosis was 14% for stage I disease, 48% for stage II, 10.6% for stage III and 38.4% for stage IV. The sites of origen were gastrointestinal tract, peripheral lymph nodes, mediastinum, Waldeyer's ring and extralymphatic sites. Leukemic picture developed in 20 children (23.5%) and central nervous system involvement occurred in 19 (23.3%). Survival was not dependant on age or sex. The prognostic value of the histologic type could not be clearly established in the present series. Survival was correlated with clinical stage and anatopmic presentation. The overall 5-year survival was 29%; survival prior to 1968 was 9% compared with 41% for children treated from 1968 to 1974. We conclude that the survival improvement in recent years is dependant on an aggressive multimodal therapeutic approach. Survival of children treated with this procedure reached 52%, compared to 25% for children who received a single agent therapy.
