Unicompartmental Knee Arthroplasty Is Cost-Effective in an Outpatient Setting.

INTRODUCTION: Increasingly, unicompartmental knee arthroplasty (UKA) is being performed on an outpatient basis, with the growing utilization of ambulatory surgery centers (ASCs). The purpose of this study was to compare the costs of UKAs performed in an ASC to UKAs done in a hospital, either on an outpatient or inpatient basis. METHODS: This study involved three matched groups, each with 50 consecutive patients, undergoing UKA either on an outpatient basis in an ASC or a community hospital, or who were admitted overnight to the same community hospital. Identical perioperative analgesic regimens and care protocols were used in each group. The primary outcomes evaluated included direct facility costs. Secondary outcomes were postoperative complications and readmissions. RESULTS: Average age, gender ratio, and comorbidities were similar in all three cohorts. Only two patients in the study experienced complications and these were without secondary adverse consequences. Mean costs were substantially reduced when UKAs were performed in an ASC ($9,025) compared to a community hospital on either an outpatient ($12,032) or inpatient basis ($14,542). CONCLUSION: UKA can be safely performed in the outpatient setting, in appropriately selected patients, at substantial cost savings, particularly when performed in an ASC.

Intraoperative Ketamine in Total Knee Arthroplasty Does Not Decrease Pain and Narcotic Consumption: A Prospective Randomized Controlled Trial.

BACKGROUND: Multiple studies have demonstrated that ketamine, a glutamate receptor blocker, may decrease postoperative pain in abdominal and orthopedic surgeries. However, its role with spinal anesthesia and total knee arthroplasty (TKA) remains unknown. The purpose of this study is to determine the efficacy of subanesthetic dosing of ketamine during TKA on postoperative pain and narcotic consumption. METHODS: In this prospective, randomized, double-blinded clinical trial, we enrolled 91 patients undergoing primary TKA with spinal anesthesia in a single institution from 2017 to 2018. Patients were randomized to receive intraoperative ketamine infusion at a rate of 6 mcg/kg/min for 75 minutes or a saline placebo. All patients received spinal anesthesia and otherwise identical surgical approaches, pain management, and rehabilitation protocols. Patient-reported visual analog pain scores were calculated preoperatively, postoperative days (POD) 0-7, and 2 weeks. Narcotic consumption was evaluated on POD 0 and 1. RESULTS: There was no difference in average pain between ketamine and placebo at all time points except for at PODs 1 (45 vs 56, P = .041) and 4 (39 vs 49, P = .040). For least pain experienced, patients administered with ketamine experienced a reduction in pain only at POD 4 (22 vs 35, P = .011). There was no difference in maximum pain cohorts at all time points of the study or in-hospital morphine equivalents between the 2 cohorts. CONCLUSION: As part of multimodal pain management protocol, intraoperative ketamine does not result in a clinically significant improvement in pain and narcotic consumption following TKA.

Radiographic Imaging in the Postanesthesia Care Unit is Unnecessary After Partial Knee Arthroplasty.

BACKGROUND: Obtaining routine radiographs in the postanesthesia care unit (PACU) after primary uncomplicated partial knee arthroplasty (PKA) is a common practice with unclear utility. The objective of this study is to determine the rate at which immediate postoperative radiographs identify an actionable problem after primary uncomplicated PKA and to determine the potential cost savings associated with foregoing the routine acquisition of these radiographs. METHODS: This was a retrospective review that assessed a consecutive series of 1366 primary uncomplicated PKAs (including 873 unicondylar knee arthroplasties, 313 patellofemoral arthroplasties, and 180 bicompartmental knee arthroplasties) performed between January 2008 and March 2016. Patients were separated into 2 cohorts: (1) those who had PACU radiographs (n = 1184), and (2) those who did not (n = 182). Operative reports and clinical follow-up records at the initial postoperative visit were reviewed to determine whether patients underwent early reoperation based on radiographic findings. The direct cost of PACU radiographs was estimated to be $33.63 based on average global Medicare payments from our institution. RESULTS: The rate of reoperation because of radiographic findings in the PACU or at the first follow-up was 0% (95% confidence interval: 0.0%-0.027%). The estimated direct radiographic expenditure for our 1366 patient cohort was nearly $46,000. CONCLUSION: Routine immediate postoperative PACU radiographs after primary uncomplicated PKA have limited clinical utility. Therefore, delaying postoperative radiographs until the initial follow-up office visit would result in substantial cost-savings without compromising the quality of patient care.

Embryonic exposure to corticosterone modifies the juvenile stress response, oxidative stress and telomere length.

Early embryonic exposure to maternal glucocorticoids can broadly impact physiology and behaviour across phylogenetically diverse taxa. The transfer of maternal glucocorticoids to offspring may be an inevitable cost associated with poor environmental conditions, or serve as a maternal effect that alters offspring phenotype in preparation for a stressful environment. Regardless, maternal glucocorticoids are likely to have both costs and benefits that are paid and collected over different developmental time periods. We manipulated yolk corticosterone (cort) in domestic chickens (Gallus domesticus) to examine the potential impacts of embryonic exposure to maternal stress on the juvenile stress response and cellular ageing. Here, we report that juveniles exposed to experimentally increased cort in ovo had a protracted decline in cort during the recovery phase of the stress response. All birds, regardless of treatment group, shifted to oxidative stress during an acute stress response. In addition, embryonic exposure to cort resulted in higher levels of reactive oxygen metabolites and an over-representation of short telomeres compared with the control birds. In many species, individuals with higher levels of oxidative stress and shorter telomeres have the poorest survival prospects. Given this, long-term costs of glucocorticoid-induced phenotypes may include accelerated ageing and increased mortality.