ABSTRACT
Asphalt is a mixture of mineral matter and bitumen, its fumes contain about 1% of Polycyclic Aromatic Hydrocarbons (PAH), some of which are carcinogens. In the PPTP-POPA Study of Lombardy Region, a group of 100 asphalt workers (exposed to bitumen fumes and diesel exhausts) and a group of 47 ground construction operators (exposed only to diesel exhausts) were investigated to assess PAH exposure in Italy, by means of environmental-air monitoring (the 16 most relevant, according to the American Environmental Protection Agency, EPA) and biological monitoring (urinary 1-hydroxypyrene excretion). Our results show that PAH exposure in these workers is not higher than that observed in traffic policemen working in urban areas. Since dermal exposure has been suggested as a major determinant of the total PAH dose absorbed by road pavers from bitumen fumes, we assessed skin contamination by organic aromatic compounds and by sixteen PAH: in both groups, six pads were applied to each subject in different parts of the body, during the workshift. The results show that the dermal contamination in road pavers is higher than in ground construction operators and that cutaneous dose rate is higher than respiratory dose rate, whereas the amount of absorption the ratio is inverted.
Subject(s)
Environmental Monitoring , Hydrocarbons/adverse effects , Inhalation Exposure , Occupational Exposure , Polycyclic Aromatic Hydrocarbons/adverse effects , Vehicle Emissions/adverse effects , Adult , Chromatography, High Pressure Liquid , Humans , Hydrocarbons/administration & dosage , Italy , Male , Polycyclic Aromatic Hydrocarbons/administration & dosage , Pyrenes/analysis , Skin/drug effectsABSTRACT
Asphalt is a mixture of bitumen, (its fumes contain about 1% of polycyclic aromatic hydrocarbons, PAH), and mineral matter. 18 Workers were investigated during road paving to assess PAH exposure by environmental air-monitoring (the 16 most relevant, according to the American Environmental Protection Agency, EPA) and biological monitoring (urinary 1-hydroxypyrene excretion). Our results show that PAH exposure in these workers is not higher than that observed in traffic policemen working in urban areas.
Subject(s)
Environmental Monitoring , Hydrocarbons/toxicity , Occupational Exposure/analysis , Polycyclic Aromatic Hydrocarbons/toxicity , Adult , Humans , MaleABSTRACT
PIP: 133 healthy patients were clinically observed for hypogalactia and divided into 3 groups. The first group of 54 seriously hypogalactic mothers and 43 hypogalactic mothers was treated with Moloco, a new placenta-extract preparation. The 2nd group of 5 seriously hypogalactic mothers and 5 moderately hypogalactic mothers were treated with placebo only. The babies of the 3rd group of seriously hypogalactic mothers were bottle fed. All babies were weighted before and after every feeding during the whole period of treatment. Results showed that Moloco actively stimulated mammary gland functions, especially in serious cases of hypogalactia, in some of which the amount of milk secreted after a month of treatment was 428% of that secreted before treatment. Babies of mothers treated with Moloco showed an increase in weight superior to that of bottle fed babies.^ieng
