Colonic perforation in 4 dogs following treatment with meloxicam.

OBJECTIVE: To describe the clinical findings and treatment of 4 dogs that developed colonic perforation shortly after meloxicam administration. SERIES SUMMARY: Three cases were treated with meloxicam for variable nonspecific signs including lethargy and pyrexia. Hemorrhagic diarrhea developed following meloxicam administration in 2 cases. Gastrointestinal perforation was suspected on diagnostic imaging leading to exploratory celiotomy in all 3 cases. Partial colectomy was performed in 2 cases and suture repair with serosal patching in 1 followed by broad spectrum antimicrobials. All 3 dogs recovered from surgery well. One dog that had undergone perineal herniorrhaphy and received meloxicam perioperatively collapsed and died 7 days postsurgery. Postmortem examination revealed ulceration and perforation of the ascending colon with resultant generalized septic peritonitis. Histopathologic findings in all cases showed full thickness infiltration of the colonic wall with inflammatory cells along with ulceration and perforation. Thrombosis of vessels underlying the ulcerated areas was also noted. NEW OR UNIQUE INFORMATION PROVIDED: This report suggests that colonic perforation may be a complication of nonsteroidal anti-inflammatory drug use in some cases. To the authors' knowledge, this has not previously been described in dogs. Colonic perforation associated with NSAIDs administration may be more commonly identified in dogs with concurrent morbidities. Caution may be warranted when using NSAIDs in dogs with colonic pathology or possible risk factors to develop such pathology. Prompt diagnosis and treatment is essential for a positive outcome.

Skull pathology in 10 cats with patellar fracture and dental anomaly syndrome.

CASE SERIES SUMMARY: The aim of this case series is to describe the clinical and radiological features of mandibular and maxillary abnormalities in cats diagnosed with patellar fractures and dental anomalies, a condition that we have named 'patellar fracture and dental anomaly syndrome' (PADS), also known previously as 'knees and teeth syndrome'. Where available, clinical records, skull and/or intraoral dental radiographs, head CT images, microbiology and histopathology reports were collected, and follow-up was obtained. Ten cats with mandibular or maxillary abnormalities were identified. Common clinical features included multiple persistent deciduous teeth, gingivitis and swellings of the jaw. Skull radiographs were available for 7/10 cats and head CT images were available for one cat. Findings included marked bony and periosteal proliferation, hypodontia, root resorption, root malformation and unerupted permanent teeth. Where available, microbiology and histopathology results were consistent with osteomyelitis. RELEVANCE AND NOVEL INFORMATION: Mandibular and maxillary abnormalities are an additional unreported clinical feature of the rare condition that we have termed PADS. Radiologically, these lesions can have an aggressive appearance, which can mimic neoplasia. Medical management with antibiotic and anti-inflammatory therapy improves clinical signs in the short term; however, surgical extraction of persistent deciduous and unerupted permanent teeth, and debridement of proliferative and necrotic bone appear to be necessary for an improved outcome. Additional information on long-term outcome is required.

Incidence and types of preceding and subsequent fractures in cats with patellar fracture and dental anomaly syndrome.

OBJECTIVES: The aim of this study was to document the incidence of preceding and subsequent fractures to the patellar fractures in cats with patellar fractures and dental anomaly syndrome. METHODS: Records of cats with patellar fracture and dental anomaly syndrome were retrieved from the combined databases at the University of Bristol, UK, and Exclusively Cats Veterinary Hospital, USA. A request was made to complete a questionnaire to obtain long-term follow-up of these cats with respect to their current status and fractures to other bones; radiographs and histories were requested and were reviewed for treatment of ongoing fractures and outcome. RESULTS: Of the 191 cases reported with this syndrome, 92 cats (48.2%) had dental anomalies and 78 (40.8%) had fractures to other bones; 21 cats sustained the fractures preceding the patellar fractures and 57 subsequently. In total, there were 175 fractures: acetabulum (25%), tibia (22%), ischium (15.4%), humeral condyle (13.7%), calcaneus (5.1%), ilium (5.1%), pubis (3.4%) and other bones (10.2%). The majority of these fractures were characteristic of insufficiency (stress) fractures with a very similar configuration in each bone. CONCLUSIONS AND RELEVANCE: A high proportion of cats with patellar fracture and dental anomaly syndrome will have preceding or subsequent fractures to their patellar fractures. In this study, >10% of cats suffered characteristic fractures preceding the patellar fractures. The presence of these fractures should alert the veterinarian to the possibility that the cat is affected by patellar fracture and dental anomaly syndrome.

A comparison of fixation methods for supracondylar and distal humeral shaft fractures of the dog and cat.

Retrospective analysis of case records from dogs and cats diagnosed with supracondylar or distal diaphyseal humeral fractures was performed. Complications were compared and outcome was assessed at final follow-up and by owner questionnaire. A total of 37 cases (25 dogs and 12 cats) were included. Methods used consisted of plates and screws or external skeletal fixator (ESF). The ESF was associated with a significantly higher rate of minor complications (14/22) compared with plates and screws (2/15). There was no difference in major or catastrophic complications between fixation methods. Major complications occurred in 4/37 cases and catastrophic complications occurred in 3/37 cases. Good or excellent outcome was achieved in 24/33 of cases. There was no difference in outcome between dogs and cats. Plates and screws or ESF can be successful methods of managing supracondylar and distal diaphyseal humeral fractures in dogs and cats. Prognosis may be more guarded, however, than previously reported.

Comparaison des méthodes de fixation pour les fractures sus-condyliennes et distales de la diaphyse chez le chien et le chat. Une analyse rétrospective des dossiers de cas de chiens et de chats diagnostiqués avec des fractures sus-condyliennes et distales de l'humérus a été réalisée. Les complications ont été comparées et les résultats ont été évalués au suivi final et à l'aide d'un questionnaire rempli par le propriétaire. Trente-sept cas (25 chiens et 12 chats) ont été inclus au total. Les méthodes utilisées comportaient des plaques et des vis ou un fixateur squelettique externe (FSE). Le FSE était associé à un taux significativement supérieur de complications mineures (14/22) comparativement aux plaques et aux vis (2/15). Il n'y avait aucune différence pour les complications majeures ou catastrophiques entre les méthodes de fixation. Des complications majeures se sont produites dans 4/37 cas et des complications majeures se sont produites dans 3/37 cas. Un résultat adéquat ou excellent a été obtenu dans 24/33 des cas. Il n'y avait aucune différence au niveau des résultats entre les chiens et les chats. Les plaques et les vis ou le FSE peuvent être des méthodes réussies de gestion des fractures sus-condyliennes et distales de la diaphyse chez les chiens et les chats. Cependant, le pronostic peut être plus réservé que ce qui avait été précédemment signalé.(Traduit par Isabelle Vallières).

Biomechanical evaluation of simulated feline patellar fracture repairs.

OBJECTIVE: To investigate four techniques for stabilization of feline patellar fracture. METHODS: Feline cadaveric stifles with simulated patellar fracture were stabilized with one of four techniques: Group A - circumferential wire, group B - figure-of-eight wire, group C - combined figure-of-eight and circumferential wire, group D - pin and tension band wire. All repairs were subjected to a period of cyclic loading prior to load to failure testing. Experiments were recorded by video capture to determine load at failure and failure mode. Failure was defined as an opening of the fracture gap of 3 mm. RESULTS: Mean fracture gap opening (±SD) during peak loading after 1000 cycles was: group A with 1.66 mm (± 0.69), group B with 1.01 mm (± 0.45), group C with 0.81 mm (± 0.58), and group D with 0.65 mm (± 0.54). Groups C and D had significantly lower mean fracture gap opening after 1000 cycles when compared to group A (p <0.05). Mean loads (± SD) at failure were: group A with 171.4 N (± 62.2), group B with 208.7 N (± 20.7), group C with 288.2 N (± 62.5), and group D with 219.5 N (± 48.0). Group C had significantly higher mean load to failure than all other groups (p <0.05). There was no difference between other groups. In groups A, B and C the principle mode of failure was wire elongation and tearing of sutures through the retinaculae and periarticular soft tissues. In group D, the principle mode of failure was the pin pulling through the bone of the distal fragment. CONCLUSIONS: Combined figure-of-eight and circumferential wires may be useful for treatment of transverse feline patellar fracture.

Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification.

High throughput screening combined with efficient datamining and parallel synthesis led to the discovery of a novel series of indolines showing potent in vitro ghrelin receptor agonist activity and acceleration of gastric emptying in rats.

Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry.

High-throughput screening of an array of biphenylmethylamines synthesised by high-throughput solid-phase chemistry resulted in the identification of compounds with high-affinity for the 5-ht5A receptor. The structure-activity relationship within this series and further array synthesis led to the identification of the biphenylmethylamine derivative 11, a potent and selective 5-ht5A receptor antagonist.