ABSTRACT
Melampodium divaricatum is a member of the Asteraceae and in Brazil is known as false-calendula, its flowers being used in anti-inflammatory preparations, substituting the true calendula or marigold (Calendula officinalis L.). The flower extract was investigated for mutagenic and antimutagenic effect in the Salmonella/microsome assay. The tested extract was not mutagenic in the strains TA100, TA98, TA97a and TA102 and decreased the mutagenicity of aflatoxin B1, benzo(a)pyrene and daunomycin. Chlorophyll and triterpenes were detected in the extract, and they might have contributed to the observed effect. Our data suggest that these medicinal plants possess cancer chemopreventive properties.
Subject(s)
Antimutagenic Agents/pharmacology , Asteraceae/chemistry , Mutagens/toxicity , Salmonella typhimurium/drug effects , Salmonella typhimurium/genetics , Aflatoxin B1/antagonists & inhibitors , Aflatoxin B1/toxicity , Animals , Anti-Bacterial Agents/antagonists & inhibitors , Anti-Bacterial Agents/toxicity , Benzo(a)pyrene/antagonists & inhibitors , Benzo(a)pyrene/toxicity , Chlorophyll/toxicity , Chromatography, Thin Layer , DNA Damage/drug effects , Daunorubicin/antagonists & inhibitors , Daunorubicin/toxicity , Dose-Response Relationship, Drug , Flowers/chemistry , Mutagenicity Tests , Mutation/drug effects , Mutation/genetics , Plant Extracts/pharmacology , Plant Extracts/toxicity , Rats , Triterpenes/toxicityABSTRACT
O pró-fármaco polimérico PDC-70 derivado do diclofenaco apresentou atividade antiedematogênica, quando administrado por via intramuscular em ratos. Além disso, produziu atividade superior à do diclofenaco de sódio. Esses resultados são promissores e indicam atividade antiinflamatória para o pró-fármaco polimérico PDC-70.