ABSTRACT
The development of moderate malnutrition and cell-mediated immune function was studied in 71 Colombian infants from birth through 2 yr of age. Based upon weight-for-age criteria 31 remained normal, 33 were classified as grade I, and seven were grade II malnourished at the end of their 2nd yr of life. Delayed hypersensitivity reactions to purified protein derivative were significantly reduced in all malnourished children 8 wk after Bacille Calmette-Guerin vaccination at birth, and also at 2 yr in the Grade II group. Nearly half of the latter group could not be sensitized to dinitrochlorobenzene at 2 yr of age. A 50% reduction in the blastogenic response of peripheral blood lymphocytes to phytohemagglutinin in vitro was detected in grade II children. Both mildly and moderately malnourished infants exhibited a significant reduction in tonsil size at 2 yr of age. These results indicate that a majority of newborns in this poor, urban setting will develop measurable malnutrition associated with impaired cell-mediated immune function before their 2nd birthday.
Subject(s)
Immunity, Cellular , Infant Nutrition Disorders/immunology , BCG Vaccine/therapeutic use , Child, Preschool , Colombia , Female , Humans , Immunization , Immunocompetence , Infant , Infant Nutrition Disorders/classification , Infant Nutrition Disorders/pathology , Infant, Newborn , Infant, Small for Gestational Age , Lymphocyte Activation , Male , Palatine Tonsil/pathology , Pregnancy , Tuberculin TestABSTRACT
Después de la vacunación contra el sarampión, un grupo de niños colombianos moderadamente desnutridos produjeron la misma cantidad de anticuerpos y tuvieron el mismo grado de morbilidad posvacunatoria que sus compañeros bien nutridos. Sobre la base de estos descubrimientos, parece que la vacuna viva y atenuada contra el sarampión es segura y eficaz en poblaciones moderadamente desnutridas (AU)
Subject(s)
Measles/immunology , /immunology , Morbidity , Vaccines, Attenuated/pharmacokinetics , Colombia/epidemiology , Urban Population , Poverty AreasABSTRACT
A computer based verification system which monitors the operation of a 4-MV linear accelerator is described. Fourteen parameters can be checked for proper alignment prior to irradiation. A training simulator was also built to minimize interference with treatment schedules and to provide technicians with experience in using the system during the developmental stages of the project.
Subject(s)
Computers , Radiotherapy/instrumentation , HumansABSTRACT
Después de la vacunación contra el sarampión, un grupo de niños colombianos moderadamente desnutridos produjeron la misma cantidad de anticuerpos y tuvieron el mismo grado de morbilidad posvacunatoria que sus compañeros bien nutridos. Sobre la base de estos descubrimientos, parece que la vacuna viva y atenuada contra el sarampión es segura y eficaz en poblaciones moderadamente desnutridas (AU)
