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1.
PLoS One ; 17(3): e0263771, 2022.
Article in English | MEDLINE | ID: mdl-35324912

ABSTRACT

The importance of gender norms in agricultural innovation processes has been recognized. However, the operational integration of these normative issues into the innovation strategies of agricultural interventions remains challenging. This article advances a replicable, integrative research approach that captures key local conditions to inform the design and targeting of gender-inclusive interventions. We focus on the gender climate across multiple contexts to add to the limited indicators available for assessing gender norms at scale. The notion of gender climate refers to the socially constituted rules that prescribe men's and women's behaviour in a specific geographic location-with some being more restrictive and others more relaxed. We examine the gender climate of 70 villages across 13 countries where agriculture is an important livelihood. Based on data from the GENNOVATE initiative we use multivariate methods to identify three principal components: 'Gender Climate', 'Opportunity' and 'Connectivity'. Pairwise correlation and variance partitioning analyses investigate the linkages between components. Our findings evidence that favourable economic or infrastructure conditions do not necessarily correlate with favourable gender normative conditions. Drawing from two case-study villages from Nepal, we highlight opportunities for agricultural research for development interventions. Overall, our approach allows to integrate local knowledge about gender norms and other local conditions into the planning and targeting strategies for agricultural innovation.


Subject(s)
Gender Identity , Men , Agriculture , Female , Humans , Male , Nepal
2.
Cell Metab ; 33(5): 873-887, 2021 05 04.
Article in English | MEDLINE | ID: mdl-33789092

ABSTRACT

The molecular circadian clock and symbiotic host-microbe relationships both evolved as mechanisms that enhance metabolic responses to environmental challenges. The gut microbiome benefits the host by breaking down diet-derived nutrients indigestible by the host and generating microbiota-derived metabolites that support host metabolism. Similarly, cellular circadian clocks optimize organismal physiology to the environment by influencing the timing and coordination of metabolic processes. Host-microbe interactions are influenced by dietary quality and timing, as well as daily light/dark cycles that entrain circadian rhythms in the host. Together, the gut microbiome and the molecular circadian clock play a coordinated role in neural processing, metabolism, adipogenesis, inflammation, and disease initiation and progression. This review examines the bidirectional interactions between the circadian clock, gut microbiota, and host metabolic systems and their effects on obesity and energy homeostasis. Directions for future research and the development of therapies that leverage these systems to address metabolic disease are highlighted.


Subject(s)
Circadian Rhythm/physiology , Diet , Gastrointestinal Microbiome , Animals , Energy Metabolism , Feeding Behavior , Host Microbial Interactions , Humans , Obesity/metabolism , Obesity/pathology , Signal Transduction
3.
Mol Neurobiol ; 57(12): 5167-5176, 2020 Dec.
Article in English | MEDLINE | ID: mdl-32860157

ABSTRACT

Cyclooxygenases are a group of heme-containing isozymes (namely Cox-1 and Cox-2) that catalyze the conversion of arachidonic acid to largely bioactive prostaglandins (PGs). Cox-1 is the ubiquitous housekeeping enzyme, and the mitogen-inducible Cox-2 is activated to cause inflammation. Interestingly, Cox-2 is constitutively expressed in the brain at the postsynaptic dendrites and excitatory terminals of the cortical and spinal cord neurons. Neuronal Cox-2 is activated in response to synaptic excitation to yield PGE2, the predominant Cox-2 metabolite in the brain, which in turn stimulates the release of glutamate and neuronal firing in a retrograde fashion. Cox-2 is also engaged in the metabolism of new endocannabinoids from 2-arachidonoyl-glycerol to modulate their actions at presynaptic terminals. In addition to these interactions, the induction of neuronal Cox-2 is coupled to the trans-synaptic activation of the dopaminergic mesolimbic system and some serotoninergic receptors, which might contribute to the development of emotional behavior. Although much of the focus regarding the induction of Cox-2 in the brain has been centered on neuroinflammation-related neurodegenerative and psychiatric disorders, some evidence also suggests that Cox-2 release during neuronal signaling may be pivotal for the fine tuning of cortical networks to regulate behavior. This review compiles the evidence supporting the homeostatic role of neuronal Cox-2 in synaptic transmission and plasticity, since neuroinflammation is originally triggered by the induction of glial Cox-2 expression. The goal is to provide perspective on the roles of Cox-2 beyond neuroinflammation, such as those played in memory and anxiety, and whose evidence is still scant.


Subject(s)
Anxiety/enzymology , Anxiety/physiopathology , Brain/enzymology , Cyclooxygenase 2/metabolism , Homeostasis , Inflammation/pathology , Memory/physiology , Neurons/pathology , Animals , Humans
4.
Gend Technol Dev ; 22(3): 222-245, 2018.
Article in English | MEDLINE | ID: mdl-31058271

ABSTRACT

Tempered radicals are change agents who experience the dominant culture as a violation of the integrity and authenticity of their personal values and beliefs. They seek to move forward whilst challenging the status quo. Does the concept provide a useful analytic lens through which the strategies of women and men farmer innovators, who are 'doing things differently' in agriculture, can be interpreted? What are their strategies for turning ambivalence and tension to their advantage? The paper uses research data derived from two wheat-growing communities in Oromia Region, Ethiopia, an area characterized by generally restrictive gendered norms and a technology transfer extension system. The findings demonstrate that women and men innovators actively interrogate and contest gender norms and extension narratives. Whilst both women and men innovators face considerable challenges, women, in particular, are precariously located 'outsiders within,' negotiating carefully between norm and sanction. Although the findings are drawn from a small sample, they have implications for interventions aiming to support agricultural innovation processes which support women's, as well as men's, innovatory practice. The framework facilitates a useful understanding of how farmer innovators operate and in particular, significant differences in how women and men interrogate, negotiate and align themselves with competing narratives.

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