Review of intervention products for use in the prevention and control of anemia.

Anemia remains a major public health problem, especially in low- and middle-income countries. The World Health Organization recommends several interventions to prevent and manage anemia in vulnerable population groups, including young children, menstruating adolescent girls and women, and pregnant and postpartum women. Daily iron supplementation reduces the risk of anemia in infants, children, and pregnant women, and intermittent iron supplementation reduces anemia risk in menstruating girls and women. Micronutrient powders reduce the risk of anemia in children. Fortifying wheat flour with iron reduces the risk of anemia in the overall population, whereas the effect of fortifying maize flour and rice is still uncertain. Regarding non-nutrition-related interventions, malaria treatment and deworming have been reported to decrease anemia prevalence. Promising interventions to prevent anemia include vitamin A supplementation, multiple micronutrient supplementation for pregnant women, small-quantity lipid-based supplements, and fortification of salt with iodine and iron. Future research could address the efficacy and safety of different iron supplementation formulations, identify the most bioavailable form of iron for fortification, examine adherence to supplementation regimens and fortification standards, and investigate the effectiveness of integrating micronutrient, helminth, and malaria control programs.

Integrating and coordinating programs for the management of anemia across the life course.

Anemia is a major global public health concern with a complex etiology. The main determinants are nutritional factors, infection and inflammation, inherited blood disorders, and women's reproductive biology, but the relative role of each varies between settings. Effective anemia programming, therefore, requires evidence-based, data-driven, contextualized multisectoral strategies, with coordinated implementation. Priority population groups are preschool children, adolescent girls, and pregnant and nonpregnant women of reproductive age. Opportunities for comprehensive anemia programming include: (i) bundling interventions through shared delivery platforms, including antenatal care, community-based platforms, schools, and workplaces; (ii) integrating delivery platforms to extend reach; (iii) integrating anemia and malaria programs in endemic areas; and (iv) integrating anemia programming across the life course. Major barriers to effective anemia programming include weak delivery systems, lack of data or poor use of data, lack of financial and human resources, and poor coordination. Systems strengthening and implementation research approaches are needed to address critical gaps, explore promising platforms, and identify solutions to persistent barriers to high intervention coverage. Immediate priorities are to close the gap between access to service delivery platforms and coverage of anemia interventions, reduce subnational coverage disparities, and improve the collection and use of data to inform anemia strategies and programming.

Reconsidering the Tolerable Upper Levels of Zinc Intake among Infants and Young Children: A Systematic Review of the Available Evidence.

Safe upper levels (UL) of zinc intake for children were established based on either (1) limited data from just one study among children or (2) extrapolations from studies in adults. Resulting ULs are less than amounts of zinc consumed by children in many studies that reported benefits of zinc interventions, and usual dietary zinc intakes often exceed the UL, with no apparent adverse effects. Therefore, existing ULs may be too low. We conducted a systematic bibliographic review of studies among preadolescent children, in which (1) additional zinc was provided vs. no additional zinc provided, and (2) the effect of zinc on serum or plasma copper, ceruloplasmin, ferritin, transferrin receptor, lipids, or hemoglobin or erythrocyte super-oxide dismutase were assessed. We extracted data from 44 relevant studies with 141 comparisons. Meta-analyses found no significant overall effect of providing additional zinc, except for a significant negative effect on ferritin (p = 0.001), albeit not consistent in relation to the zinc dose. Interpretation is complicated by the significant heterogeneity of results and uncertainties regarding the physiological and clinical significance of outcomes. Current zinc ULs should be reassessed and potentially revised using data now available for preadolescent children and considering challenges regarding interpretation of results.

Successful delivery of nutrition programs and the sustainable development goals.

Malnutrition affects millions of people globally, especially women, children, and other vulnerable populations. Sustainable Development Goals (SDGs) were set in 2015 to end poverty, protect the planet, and improve the lives and prospects of everyone by 2030. To achieve the SDG goals effective nutrition interventions and programs need to be efficiently delivered to those most in need. Nutrition directly affects 2 SDGs (2 and 3) and indirectly influences five others. In addition, almost all SDGs influence nutrition and thus attaining the SDG goals is also a pre-requisite to achieving the Global Nutrition targets set in 2012. Evidence-based nutrition interventions, for which there is strong evidence of their biological impact, have the potential to directly influence SDGs 2 and 3 if successfully delivered at scale in high-burden countries. Nevertheless, delivery of nutrition programs is a complex process, where policy, government commitment, adequate budget allocation, supplies and delivery systems, training of service providers, informed beneficiaries and program monitoring and evaluation all need to be in place and aligned with each other. Although in the past decade there has been progress in the SDGs that nutrition directly affects, many goals are still off-track, likely due to several pending gaps at policy-level, program-level, and intervention-level. To accelerate the progress toward reaching the SDG goals that are directly influenced by nutrition, countries need to be supported to successfully and sustainably deliver proven interventions and to scale-up and deliver new interventions in new and innovative ways, and the evidence base should be built in promising areas especially integrating (rather than prioritizing over each other) nutrition-specific and sensitive approaches.

Malnutrition in all its forms and socio-economic disparities in children under 5 years of age and women of reproductive age in Peru.

OBJECTIVE: To compare the distribution of malnutrition by socio-economic indicators (SEI) in Peruvian children under 5 years and women of reproductive age (WRA). DESIGN: We analysed data from the National Demographic and Family Health Survey. WHO criteria were used to define malnutrition indicators (overweight/obesity combined (OW); wasting/underweight; stunting/short stature; anaemia). Linear combination test was used to compare the prevalence of malnutrition by SEI (wealth index as a proxy of socio-economic status (SES); education; ethnicity). Prevalence ratio (PR) was used to describe disparities and associations between malnutrition and SEI. SETTING: Peru (2015). PARTICIPANTS: Children (n 22 833) under 5 years and WRA (n 33 503; 5008 adolescents and 28 495 adults). RESULTS: The most prevalent form of malnutrition was anaemia (32·0 %) in children and OW in adolescent and adult WRA (31·3 and 65·1 %, respectively). Adjusted models showed that stunting and anaemia were significantly lower among children with high SES (PR = 0·25, 0·67), high-educated mothers (PR = 0·26, 0·76) and higher in indigenous children (PR = 1·3, 1·2); conversely, OW was higher among those with high SES and high-educated mothers (PR = 1·8, 1·6) compared with their lowest counterparts. In WRA, stunting/short stature was lower among those with high SES, high education and higher in indigenous adult women. OW in adolescents and adults was higher in high SES (PR = 1·4, 1·1), lower in indigenous adult women (PR = 0·84) and lower in high-educated adult women (PR = 0·86). CONCLUSIONS: In the studied population, the distribution of malnutrition was associated with SEI disparities. Effective policies that integrate actions to overcome the double burden of malnutrition and reduce disparities are needed.

Tackling malnutrition in Latin America and the Caribbean: challenges and opportunities / La lucha contra la malnutrición en América Latina y el Caribe: retos y oportunidades

Undernutrition and micronutrient deficiencies are still a public health problem in Latin America and the Caribbean (LAC), and overweight and obesity have reached epidemic proportions. To assess the nutrition landscape in LAC countries and guide future nutrition efforts and investments, the Pan American Health Organization and the Micronutrient Initiative joined efforts to 1) identify information gaps and describe the current nutritional situation in the region; 2) map existing policies to address malnutrition in Latin America; 3) describe the impact of conditional cash transfer programs (CCTs) on nutrition and health outcomes; and 4) identify the challenges and opportunities to address malnutrition in the region. This article summarizes the methods and key findings from that research and describes the current challenges and opportunities in addressing malnutrition in the LAC region. LAC countries have advanced in reducing undernutrition and micronutrient deficiencies, but important gaps in information are a major concern. These countries have policies to address undernutrition and micronutrient deficiencies, but comprehensive and intersectoral policies to tackle obesity are lacking. CCTs in Brazil, Colombia, and Mexico have been reported to have a positive impact on child nutrition and health outcomes, providing an opportunity to integrate nutrition actions in intersectoral platforms. The current epidemiological situation and policy options offer an opportunity for countries, technical agencies, donors, and other stakeholders to jointly scale up nutrition actions. This can support the development of comprehensive and intersectoral policies to tackle the double burden of malnutrition, strengthen national nutrition surveillance systems, incorporate monitoring and evaluation as systematic components of policies and programs, document and increase investments in nutrition, and assess the effectiveness of such policies to support political commitment and guarantee sustainability.

La desnutrición y las carencias de micronutrientes siguen siendo un problema de salud pública en América Latina y el Caribe y el sobrepeso y la obesidad han alcanzado proporciones epidémicas. Para evaluar el panorama nutricional en los países de América Latina y el Caribe y marcar el rumbo de futuras iniciativas e inversiones en el área de la nutrición, la Organización Panamericana de la Salud y la Iniciativa de Micronutrientes aunaron esfuerzos a fin de a) identificar brechas de información y describir la situación nutricional actual en la Región; b) mapear las políticas existentes para combatir la malnutrición en América Latina; c) describir los efectos que tienen los programas de transferencias de efectivo condicionadas sobre la nutrición y la salud; y d) determinar los retos y oportunidades que encierra la lucha contra la malnutrición en la Región. En el presente artículo se resumen los métodos usados en esa investigación y sus principales resultados, y se describen los retos y oportunidades que plantea actualmente la lucha contra la malnutrición en América Latina y el Caribe. Los países de la Región han avanzado en sus esfuerzos por reducir la desnutrición y las carencias de micronutrientes, pero hay grandes lagunas de información que constituyen un problema serio. Dichos países tienen políticas dirigidas a combatir la desnutrición y las carencias de micronutrientes, pero no tienen políticas integrales e intersectoriales para hacer frente al problema de la obesidad. Se ha señalado que en Brasil, Colombia y México las transferencias monetarias condicionadas tienen un efecto beneficioso sobre el estado nutricional y de salud del niño, lo que representa una oportunidad para integrar intervenciones nutricionales en las plataformas intersectoriales. La situación epidemiológica y las opciones normativas del momento actual brindan a los países, a los organismos técnicos, a los donantes y a otros interesados directos la oportunidad de ampliar, en conjunto, el alcance de las medidas en materia de nutrición. Esto puede estimular la formulación de políticas integrales e intersectoriales para combatir la doble carga de malnutrición, fortalecer los sistemas nacionales de vigilancia nutricional, incorporar el seguimiento y la evaluación como componentes sistemáticos de las políticas y programas, documentar e incrementar la inversión en el área de la nutrición y evaluar la eficacia de estas políticas para fomentar el compromiso político y garantizar la sostenibilidad.

Nutrition situation in Latin America and the Caribbean: current scenario, past trends, and data gaps / Situación nutricional en América Latina y el Caribe: panorama actual, tendencias y brechas en la información

Objective. To determine the current nutritional status in Latin America and the Caribbean (LAC) and identify data gaps and trends in nutrition surveillance. Methods. A systematic Internet search was conducted to identify official sources that allowed for monitoring of LAC countries’ nutritional status, including progress toward World Health Organization Global Nutrition Targets 2025. Reports from national nutrition surveillance systems and reports on nationally representative surveys were collected and collated to 1) analyze nutritional status, based on life-course anthropometric indicators and biomarkers, and 2) identify gaps in data availability and trends in nutritional deficiencies. Information on iron, vitamin A, iodine, folate, and vitamin B12 deficiency was also collected and collated. Results. Twenty-two of the 46 LAC countries/territories (48%) had information on undernutrition (stunting, underweight, and wasting) in children under 5 years old and women of reproductive age (WRA). Seventeen countries (38%) had information on anemia in children under 5 years old and WRA, and 12 (27%) had information on anemia in pregnant women. Although overall nutritional status has improved in the past few decades in all countries in the region, some LAC countries still had a high prevalence of stunting and anemia in children and WRA. Overweight affected at least 50% of WRA in nine countries with available data, and was increasing in children. Data for school-age children, adolescents, adult males, and older adults were scarce in the region. Conclusions. Overall nutritional status has improved in the LAC countries with available information, but more efforts are needed to scale up nutrition-sensitive and nutrition-specific interventions to tackle malnutrition in all its forms, as stunting, anemia, and vitamin A deficiency are still a public health problem in many countries, and overweight is an epidemic. Nutrition information systems are weak in the region, and countries need to strengthen their capacity to monitor nutritional status indicators.

Objetivo. Determinar la situación actual de las carencias nutricionales en América Latina y el Caribe (ALC) e identificar las deficiencias en los datos y el curso actual de la vigilancia en materia de nutrición. Métodos. Se realizó una búsqueda sistemática de la internet para encontrar fuentes oficiales dedicadas a observar la evolución de la situación nutricional de los países de América Latina y el Caribe, incluidos los avances en relación con las metas mundiales de nutrición fijadas por la Asamblea Mundial de la Salud para el 2025. Se recopilaron y compaginaron los informes de diferentes sistemas de vigilancia nutricional nacionales y de encuestas representativas de alcance nacional con el fin de: (1) analizar la situación nutricional con respecto a indicadores antropométricos y marcadores biológicos para todas las etapas de la vida y (2) detectar brechas en la disponibilidad de datos y observar la evolución de las carencias nutricionales. También se recopiló y compaginó información relativa a la carencia de hierro, vitamina A, yodo, folato y vitamina B12. Resultados. Veintidós países de América Latina y el Caribe (48%) contaban con información acerca de la desnutrición (retraso del crecimiento, peso inferior al normal y emaciación) en niños menores de 5 años de edad, niños en edad escolar, adolescentes y mujeres en edad fecunda (MEF). Diecisiete países (38%) tenían información sobre la anemia en niños menores de 5 años; 12 (27%) la tenían sobre la anemia en MEF. Aunque la situación nutricional en general ha mejorado en los últimos decenios en todos los países de la Región, algunos países de América Latina y el Caribe siguen teniendo una alta prevalencia de retraso del crecimiento y anemia en niños y MEF. El sobrepeso afectaba a por lo menos 50% de las MEF en nueve de los países que poseían datos y estaba aumentando en los niños. En la Región hay pocos datos relativos a los niños en edad escolar, los adolescentes, los hombres adultos y las personas de edad. Conclusiones. La situación nutricional en general ha mejorado en los países de América Latina y el Caribe para los cuales se cuenta con información, pero hay que tomar más medidas para incrementar las intervenciones relacionadas de manera tangencial o directa con la nutrición a fin de combatir la desnutrición en todas sus manifestaciones, habida cuenta de que el retraso del crecimiento, la anemia y la carencia de vitamina A siguen siendo problemas de salud pública en muchos países y que el sobrepeso constituye una epidemia. Los sistemas de información nutricional de la Región son pobres y los países tienen que fortalecer su capacidad para vigilar los indicadores de la situación nutricional.

Prepubertal Adiposity, Vitamin D Status, and Insulin Resistance.

OBJECTIVE: To evaluate the following from prepuberty to the puberty-onset: (1) changes in serum 25-hydroxyvitamin-D (25[OH]D), adiposity, and insulin resistance (IR); (2) the effect of prepubertal adiposity on serum 25(OH)D changes; and (3) the combined effect of prepubertal obesity and suboptimal-25(OH)D on IR at puberty-onset. METHODS: A total of 426 prepubertal children (∼54% girls) were followed during pubertal-onset assessing before and after puberty-onset serum 25(OH)D, adiposity (BMI and waist circumference) and IR indicators (homeostasis-model-assessment of IR [HOMA-IR]). Associations were tested using multiple and logistic regression models adjusted by age, gender, and seasonality. RESULTS: At puberty-onset, mean serum 25(OH)D decreased (32.2 ± 8.9 Tanner I vs 25.2 ± 8.3 ng/mL Tanner II) and total and central obesity increased (BMI-for-age-z-score ≥2 SD [%]: 16.4 vs 22.1; waist-circumference ≥75th percentile [%]: 27.2 vs 37.1, all P < .05). Children with higher adiposity before puberty onset had higher risk of suboptimal-25(OH)D (<30 ng/mL) in Tanner II (ie, odds ratio = 2.7 [1.1-6.7] for obesity and 2.7 [1.4-5.5] for central-obesity) after adjusting for relevant covariates. Children with higher adiposity and suboptimal-25(OH)D before puberty-onset had higher HOMA-IR compared with their counterparts in Tanner II (HOMA-IR: 2.8 [2.5-3.1] if central-obese and suboptimal-25[OH]D vs 2.1 [1.9-2.3] no central-obesity and optimal-25[OH]D). CONCLUSIONS: We found that serum 25(OH)D declined with puberty-onset, likely because of adiposity increase. Moreover, children with the combined condition of central-obesity and suboptimal-25(OH)D before puberty-onset had higher pubertal IR. These results highlight the need of ensuring adequate-25(OH)D status before pubertal-onset, particularly in obese children.

Folate and Vitamin B12 Status in Latin America and the Caribbean: An Update.

UNLABELLED: Background: The current magnitude of folate and vitamin B12 deficiency in Latin America and the Caribbean is uncertain. OBJECTIVE: To summarize data on plasma or serum vitamin B12 and folate concentrations in Latin America and the Caribbean reported since 1990, a period that covers the era before and after the introduction of folic acid fortification. METHODS: A systematic review was conducted in 2012 and updated in 2014. Studies and surveys using biochemical biomarkers and conducted in apparently healthy individuals were identified. RESULTS: Folate deficiency in Latin America and the Caribbean appears not to be a public health problem (prevalence < 5%) after the introduction of folic acid fortification. However, there is some indication that high rates of low or marginal vitamin B12 status remain in most locations and across population groups. CONCLUSIONS: Adding vitamin B12 as a fortificant with folic acid may be the best strategy in areas where vitamin B12 deficiency is an established concern.

Prevalence of Anemia in Latin America and the Caribbean.

BACKGROUND: In Latin America and the Caribbean, anemia has been a public health problem that affects mainly women of childbearing age and children under 6 years of age. However, the current prevalence of anemia in this region is unknown. OBJECTIVE: To examine the latest available prevalence data on anemia in Latin America and the Caribbean. METHODS: A systematic review was conducted in 2011 and updated in 2014. Studies determining the prevalence of anemia conducted in apparently healthy populations with national or regional representativeness were included in the review. RESULTS: The lowest prevalence rates of anemia among children under 6 years of age were found in Chile (4.0%), Costa Rica (4.0%), Argentina (7.6%), and Mexico (19.9%). In Nicaragua, Brazil, Ecuador, El Panama, and Honduras, anemia was a moderate public health problem, with prevalence ranging Salvador, Cuba, Colombia, the Dominican Republic, Peru, from 20.1% to 37.3%. Anemia was a severe public health problem in Guatemala, Haiti, and Bolivia. The prevalence of anemia among women of childbearing age was lowest in Chile (5.1%). In Colombia, El Salvador, Costa Rica, Nicaragua, Ecuador, Mexico, Peru, Honduras, and Argentina, anemia was a mild public health problem, with prevalence ranging from 7.6% to 18.7%. In Guatemala, Brazil, the Dominican Republic, and Bolivia, anemia was a moderate public health problem, with prevalence ranging from 21.4% to 38.3%. Panama and Haiti had the highest reported prevalence rates (40.0% and 45.5%, respectively), and anemia was considered a severe public health problem in those countries. CONCLUSIONS: Anemia remains a public health problem in children under 6 years of age and women of childbearing age in most Latin America and Caribbean countries for which data are available.

Zinc Deficiency in Latin America and the Caribbean.

BACKGROUND: Zinc deficiency affects multiple vital functions in the life cycle, especially growth. Limited information is available on the magnitude of zinc deficiency in Latin America and the Caribbean. OBJECTIVE: To examine the latest available information on both the prevalence of zinc deficiency and the risk of zinc deficiency in Latin America and the Caribbean. METHODS: The prevalence of zinc deficiency was identified through a systematic review looking for the latest available data on serum zinc concentrations from surveys or studies with national representativeness conducted in Latin America and the Caribbean. The risk of zinc deficiency in Latin America and the Caribbean was estimated based on dietary zinc inadequacy (according to the 2011 National Food Balance Sheets) and stunting in children under 5 years of age. RESULTS: Only four countries had available national biochemical data. Mexican, Colombian, Ecuadorian, and Guatemalan children under 6 years of age and women 12 to 49 years of age had a high prevalence of zinc deficiency (19.1% to 56.3%). The countries with the highest risk of zinc deficiency (estimated prevalence of inadequate zinc intake > 25% plus prevalence of stunting > 20%) were Belize, Bolivia, El Salvador, Guatemala, Haiti, Honduras, Nicaragua, and Saint Vincent and the Grenadines. Zinc dietary inadequacy was directly correlated with stunting (r = 0.64, p < .001). CONCLUSIONS: Prevalence data from the four available Latin America and Caribbean national surveys indicate a high prevalence of zinc deficiency in children under 6 years of age and women 12 to 49 years of age. High rates of both estimated zinc dietary inadequacy and stunting were also reported in most Latin America and Caribbean countries.

Introduction: Prevalence of Micronutrient Deficiencies in Latin America and the Caribbean.

This Food and Nutrition Bulletin supplement summarizes updated prevalence data on micronutrient deficiencies in Latin America and the Caribbean (LAC). In order to provide an updated view of micronutrient status in LAC, systematic reviews were performed utilizing national health surveys and research-oriented studies focused on the prevalence of deficiencies of vitamin A, folate, anemia (as a proxy of iron deficiency), and zinc. Results show that the prevalence of vitamin A deficiency has been reduced in many countries, folate deficiency is now almost non-existent, low or marginal vitamin B12 status is still prevalent in most locations, anemia remains a public health problem among children under 6 years of age and women of childbearing age in most surveyed countries, and there is a high prevalence of zinc deficiency in children under 6 years of age and girls and women 12 to 49 years of age. Thus, regardless of improvements in the overall rates of economic growth in LAC, deficiencies of these micronutrients still remain a public health problem.

Interpretation of Serum Retinol Data From Latin America and the Caribbean.

BACKGROUND: In recent decades, the general socioeconomic situation in Latin America and the Caribbean countries has improved, and many vitamin A programs have been implemented in an attempt to reduce vitamin A deficiency in the region. OBJECTIVE: To examine vitamin A status in Latin America and the Caribbean based on serum retinol concentrations and to contrast available data published before and after 1998. METHODS: A systematic review was performed. National surveys or representative studies that reported vitamin A status were selected. RESULTS: Ten national surveys and six representative studies were identified. Data for children under 6 years of age indicate that Guatemala and Nicaragua have practically eradicated vitamin A deficiency (less than 2% prevalence of serum retinol < 20 µg/dL). In Costa Rica, Cuba, El Salvador, and Panama, the prevalence of vitamin A deficiency ranged from 2.8% to 9.4%. In Peru, Honduras, Argentina, Ecuador, and Brazil, vitamin A deficiency is a moderate public health problem (prevalence from 14.0% to 17.4%), while in Colombia, Mexico, and Haiti it is a severe public health problem (prevalence from 24.3% to 32.0%). Disadvantaged groups (indigenous people and those of Afro-Colombian descent) have the highest rates of deficiency. The prevalence of vitamin A deficiency is under 20% in school-children and adult women. When data published before and after 1998 for children under 6 years of age were compared, most Central American countries had a reduction in the prevalence of vitamin A deficiency (p < .05), whereas in South American countries, the prevalence of vitamin A deficiency increased over time (p < .05). CONCLUSIONS: The prevalence of vitamin A deficiency in children under 6 years of age has decreased in many Central American countries, but vitamin A deficiency still remains a public health problem in numerous Latin America and Caribbean countries, especially among disadvantaged and vulnerable groups. Because of issues with the accuracy of the serum retinol biomarker reflecting body stores, these results must be interpreted with caution.

Body mass index, iron absorption and iron status in childbearing age women.

BACKGROUND: The prevalence of obesity has increased at an alarming rate worldwide. Some studies have observed an association between iron (Fe) deficiency (ID) and obesity, however more research is needed. OBJECTIVE: To assess whether body mass index (BMI) is associated with both Fe absorption and Fe status. METHODS: A cross sectional sample of 318 Chilean childbearing age women was studied. The women received either a single dose of 0.5mg of Fe (n=137, group 1) or 3mg of Fe plus ascorbic acid (1:2 molar ratio) (n=181, group 2), both as FeSO4 with labeled radioisotopes. Fe absorption was assessed through radio Fe erythrocyte incorporation. Fe status was determined by hemoglobin (Hb), mean corpuscular volume, serum Fe, total iron binding capacity, transferrin saturation, erythrocyte Zn protoporphyrin and serum ferritin (SF). RESULTS: 29%, 47% and 24% of the women were classified as normal, overweight or obese, respectively. Fe absorption was significantly lower in obese women (p<0.05). In group 1, the geometric mean and range ±1 SD of the percentage of Fe absorption for normal-weight women was 32.9% vs. 19.7% in obese. For group 2, this percentage was 36% vs. 30%, respectively (2-way ANOVA: BMI classification and Fe dose p<0.05; interaction p=0.34). Although Fe absorption was lower in obese women, they had higher SF (p<0.01) and Hb (p<0.05) concentrations. CONCLUSION: Although we did not observe a relationship between BMI and Fe status, obese women displayed lower Fe absorption compared with overweight and normal weight women, possibly due to subclinical inflammation associated with obesity.

Consejería nutricional incrementa el consumo de alimentos ricos en calcio, pero la ingesta se mantiene por debajo del requierimiento diario / Nutritional counseling increases consumption of calcium-rich foods, but mean intake remains below the daily requirement

Calcium (Ca) plays a crucial role in the regulation of metabolic processes, especially neuromuscular function and bone health. In Chile, calcium intake in women of childbearing age does not meet the dietary requirement. Objective: To determine whether standard and virtual nutritional counseling increases the dietary calcium intake in Chilean women of childbearing age. Subjects and Methods: Dietary calcium intake in 20 women (mean age 39 ± 5 years) before and after a nutritional education intervention was compared. Nutritional counseling was provided to promote daily consumption of calcium-rich foods. Subsequently, a virtual space was provided to enhance standard counseling. On days 1, 30 and 62 a semi-quantitative food frequency questionnaire was completed by the women. Calcium intake significantly increased post intervention (ANOVA F = 4.43, P= 0.02). Dietary calcium intake was 308 ± 116mg/d at baseline, 354 ± 138mg/d at 30 days, and 412 ± 188mg/d after 62 days. Post intervention, 95% of the participants did not meet the daily intake requirement for calcium; the average percent of adequate intake of calcium was 68 ± 19%. Conclusion: Nutritional counseling increased dietary calcium intake in women of reproductive age, but the increase was not enough to meet the daily calcium requirements.

El calcio juega un rol crucial en la regulación de procesos metabólicos, especialmente en la función neuromuscular y en la salud ósea. Sin embargo, la ingesta dietaria de calcio en mujeres en edad fértil de Chile no cubre los requerimientos. Objetivo: determinar sí la consejería nutricional presencial y virtual incrementa la ingesta dietaria de calcio en mujeres chilenas de edad fértil. Sujetos y métodos: la ingesta dietaria de calcio en 20 mujeres (edad media de 39 ± 5 años) antes y después de una intervención de educación alimentaria y nutricional fue comparada. La consejería nutricional fue impartida para promover el consumo diario de alimentos ricos en calcio. Además, se habilitó un espacio virtual para reforzar la consejería nutricional. En el día 1, 30 y 62 se aplicaron cuestionarios de frecuencia de consumo semi-cuantitativos. La ingesta dietaria de calcio incrementó significativamente (ANOVA F = 4.43, P= 0.02) después de la intervención. La ingesta dietaria de calcio fue 308 ± 116mg/d al día 1, 354 ± 138mg/d al día 30, e incrementó a 412 ± 188mg/d después de 62 días. Al final de la intervención, el 95% de las participantes no cubrieron sus requerimientos diarios de calcio; la media del porcentaje de adecuación para la ingesta de calcio fue 68 ± 19%. La consejería nutricional podría incrementar la ingesta dietaria de calcio en mujeres de edad media en Chile. Sin embargo, el aumento no es suficiente para cubrir los requerimientos de calcio.

Low prevalence of iron deficiency anemia between 1981 and 2010 in Chilean women of childbearing age / Baja prevalencia de anemia por deficiencia de hierro entre 1981 y 2010 en mujeres chilenas en edad fértil

Objective. To determine the prevalence of anemia and iron status among Chilean women of childbearing age between 1981 and 2010. Materials and methods. Calculation of the prevalence of anemia and iron status was based on multiple cross-sectional iron absorption studies performed in 888 women during this period of time. All studies included measurements of hemoglobin, mean corpuscular volume, zinc protoporphyrin, percentage of transferrin saturation and serum ferritin. Data were grouped by decade (1981-1990, 1991-2000, and 2001-2010). Results. Prevalence of anemia for these decades was 9, 6 and 10%, respectively (p=NS). Iron deficiency anemia was the main cause of anemia in all periods (55, 85 and 75%, respectively; p=NS). A high prevalence of women with normal iron status was observed for all periods (64, 69, and 67, respectively; p=NS). Prevalence of iron deficiency without anemia in 1981-1990, 1991-2000 and 2001-2010 was 7, 20 and 12%, respectively (p<0.05). Finally, prevalence of iron depleted stores was 20, 6 and 10%, respectively (p<0.05). Conclusions. Prevalence of iron deficiency anemia in Chilean women of childbearing age was mild between 1981 and 2010. More than 60% of childbearing age women presented normal iron status in all periods. However, prevalence of iron depleted stores was moderate during 1981-1990, and was mild during 1991-2000 and 2001-2010.

Objetivo. Determinar la prevalencia de anemia y el estado de nutrición de hierro entre 1981 y 2010 en mujeres chilenas en edad fértil. Material y métodos. La prevalencia de anemia y el estado de nutrición de hierro fueron calculados con base en múltiples estudios transversales de absorción de hierro realizados en 888 mujeres. Estos estudios incluían medición de hemoglobina, volumen corpuscular medio, zinc protoporfirina, porcentaje de saturación de transferrina y ferritina sérica. Los datos fueron agrupados por décadas (1981-1990, 1991-2000, y 2001-2010). Resultados. La prevalencia de anemia para estas décadas fue de 9, 6 y 10%, respectivamente (p=NS). La anemia por deficiencia de hierro fue la principal causa de anemia en los periodos evaluados (55, 85 y 75%, respectivamente; p=NS). Una alta prevalencia de mujeres con estado de nutrición normal de hierro fue observado en todos los periodos (64, 69, y 67%, respectivamente; p=NS). La prevalencia de deficiencia de hierro sin anemia fue de 7, 20 y 12%, respectivamente (p<0.05). Finalmente, la prevalencia de depleción de depósitos de hierro fue de 20, 6 y 10%, respectivamente (p<0.05). Conclusiones. La prevalencia de anemia por deficiencia de hierro en mujeres chilenas en edad fértil clasifica como leve entre 1981 y 2010. Más de 60% de las mujeres en edad fértil presentó estado nutricional normal de hierro en todos los periodos. Sin embargo, la depleción de depósitos de hierro fue moderada durante 1981-1990, y fue leve durante 1991-2000 y 2001-2010.

Less than adequate vitamin D status and intake in Latin America and the Caribbean:a problem of unknown magnitude.

BACKGROUND: The prevalence of vitamin D deficiency in Latin America and the Caribbean is unknown. OBJECTIVE: To examine the prevalence data available on vitamin D deficiency in Latin America and the Caribbean. METHODS: A systematic review was conducted in 2011. Studies using biochemical biomarkers and dietary intake estimation were included. Studies conducted in apparently healthy individuals, independently of age, latitude, skin pigmentation, and season of the year at the time of blood collection, were included. RESULTS: A total of 243 studies were identified. The final number of selected studies was 28, including two National Health Surveys (Mexico and Argentina). There are studies that report the vitamin D status of specific subgroups conducted in Argentina, Brazil, Chile, Colombia, Ecuador, Guatemala, and Mexico. However, the small sample sizes in these studies and thus the low national representativeness of the reported data do not allow for an accurate assessment of vitamin D status at the regional level. In the majority of the countries with available data, we observed that vitamin D insufficiency was classified as a mild, moderate, or severe public health problem. The only country with a nationally representative sample was Mexico, which found 24%, 10%, 8%, and 10% prevalence rates of vitamin D insufficiency (25-hydroxyvitamin D < 50 nmol/L) in preschoolers, schoolchildren, adolescents, and adults, respectively. The prevalence of vitamin D deficiency (25-hydroxyvitamin D < 20 nmol/L) was less than 1% for all groups. CONCLUSIONS: There is some indication that vitamin D insufficiency may be a public health problem in Latin America and the Caribbean, but the exact magnitude is currently unknown.

Effect of zinc sulfate fortificant on iron absorption from low extraction wheat flour co-fortified with ferrous sulfate.

UNLABELLED: The co-fortification of wheat flour with iron (Fe) and zinc (Zn) is a strategy used to prevent these deficiencies in the population. Given that Zn could interact negatively with Fe, the objective was to assess the effect of Zn on Fe absorption from bread prepared with wheat flour fortified with Fe and graded levels of Zn fortificant. Twelve women aged 30-43 years, with contraception and a negative pregnancy test, participated in the study. They received on four different days, after an overnight fast, 100 g of bread made with wheat flour (70 % extraction) fortified with 30 mg Fe/kg as ferrous sulfate (A) or prepared with the same Fe-fortified flour but with graded levels of Zn, as zinc sulfate: 30 mg/kg (B), 60 mg/kg (C), or 90 mg/kg (D). Fe radioisotopes ((59)Fe and (55)Fe) of high specific activity were used as tracers and Fe absorption iron was measured by the incorporation of radioactive Fe into erythrocytes. RESULTS: The geometric mean and range of ± 1 SD of Fe absorption were: A= 19.8 % (10.5-37.2 %), B = 18.5 % (10.2-33.4 %), C = 17.7 % (7.7-38.7 %), and D = 11.2 % (6.2-20.3 %), respectively; ANOVA for repeated measures F = 5.14, p < 0.01 (Scheffè's post hoc test: A vs D and B vs D, p < 0.05). We can conclude that Fe is well absorbed from low extraction flour fortified with 30 mg/kg of Fe, as ferrous sulfate, and up to 60 mg/kg of Zn, as Zn sulfate. A statistically significant reduction of Fe absorption was observed at a Zn fortification level of 90 mg Zn/kg.

Low prevalence of iron deficiency anemia between 1981 and 2010 in Chilean women of childbearing age.

OBJECTIVE: To determine the prevalence of anemia and iron status among Chilean women of childbearing age between 1981 and 2010. MATERIALS AND METHODS: Calculation of the prevalence of anemia and iron status was based on multiple cross-sectional iron absorption studies performed in 888 women during this period of time. All studies included measurements of hemoglobin, mean corpuscular volume, zinc protoporphyrin, percentage of transferrin saturation and serum ferritin. Data were grouped by decade (1981-1990, 1991-2000, and 2001-2010). RESULTS: Prevalence of anemia for these decades was 9, 6 and 10%, respectively (p=NS). Iron deficiency anemia was the main cause of anemia in all periods (55, 85 and 75%, respectively; p=NS). A high prevalence of women with normal iron status was observed for all periods (64, 69, and 67, respectively; p=NS). Prevalence of iron deficiency without anemia in 1981-1990, 1991-2000 and 2001-2010 was 7, 20 and 12%, respectively (p<0.05). Finally, prevalence of iron depleted stores was 20, 6 and 10%, respectively (p<0.05). CONCLUSIONS: Prevalence of iron deficiency anemia in Chilean women of childbearing age was mild between 1981 and 2010. More than 60% of childbearing age women presented normal iron status in all periods. However, prevalence of iron depleted stores was moderate during 1981-1990, and was mild during 1991-2000 and 2001-2010.

Effect of increasing concentrations of zinc on the absorption of iron from iron-fortified milk.

The cofortification of milk with iron (Fe) and zinc (Zn) is a strategy used to prevent these deficiencies during childhood. Given that Zn can negatively interact with iron in aqueous solutions, the objective of the present study was to determine the effect of Zn on Fe absorption of milk fortified with Fe and Zn. Twenty-eight women between 33 and 47 years of age, with contraception and a negative pregnancy test, participated in one of two absorption studies. They received on four different days, after an overnight fast, 200 mL of milk (26 % fat) fortified with 10 mg Fe/L, as (A) ferrous sulfate, or the same milk but with graded doses of added Zn, as Zn sulfate of (B) 5, (C) 10, and (D) 20 mg/L (study 1, n = 15). In study 2 (n = 13), subjects received the same milk formulations, but these were also fortified with ascorbic acid (70 mg/L). Milk was labeled with radioisotopes 59Fe or 55Fe, and the absorption of iron was measured by erythrocyte incorporation of radioactive Fe. The geometric mean and range of ±1 SD of Fe absorption in study 1 were as follows: formula A = 6.0 % (2.8-13.0 %); B = 6.7 % (3.3-13.6 %); C = 5.4 % (2.2-13.2 %); and D = 5.2 % (2.8-10.0 %) (ANOVA for repeated measures, not significant). For study 2, data are as follows: 8.2 % (3.6-18.7 %); B = 6.4 % (2.5-16.4 %); C = 7.7 % (3.2-18.9 %); and D = 5.2 (1.8-14.8 %) (ANOVA for repeated measures, not significant). In conclusion, according to the results from this study, it appears that the addition of zinc up to 20 mg/L does not significantly inhibit iron absorption from milk fortified with 10 mg/L of iron.