Subject(s)
Antibodies, Monoclonal/therapeutic use , Antineoplastic Agents/therapeutic use , Breast Neoplasms/drug therapy , Metformin/therapeutic use , Antibodies, Monoclonal, Humanized , Breast Neoplasms/genetics , Clinical Trials, Phase II as Topic , Female , Humans , Italy , Neoadjuvant Therapy , Randomized Controlled Trials as Topic , Receptor, ErbB-2/biosynthesis , Receptor, ErbB-2/genetics , Translational Research, Biomedical , TrastuzumabSubject(s)
Biomarkers, Tumor/metabolism , Breast Neoplasms/metabolism , Breast Neoplasms/pathology , Carcinoma/metabolism , Carcinoma/pathology , Neoplastic Stem Cells/pathology , Breast Neoplasms/diagnosis , Breast Neoplasms/genetics , Carcinoma/diagnosis , Carcinoma/genetics , Female , Gene Expression Regulation, Neoplastic , Humans , Lymphatic Metastasis , Neoplasm Metastasis , Neoplasm Seeding , Neoplastic Stem Cells/metabolismABSTRACT
OBJECTIVE: To report an additional case of collecting duct carcinoma of the kidney, known as carcinoma of Bellini. METHODS/RESULTS: A 65-year-old male patient was admitted for left renal pain. An ultrasound scan showed a solid right renal mass. The patient underwent extended radical nephrectomy. Pathological analysis of the surgical specimen disclosed carcinoma of Bellini. The patient is asymptomatic 18 months postoperatively. CONCLUSIONS: Carcinoma of Bellini is an uncommon tumor type arising from the collecting duct cells and accounts for 0.5%-2% of all renal tumors.
Subject(s)
Carcinoma, Renal Cell/pathology , Kidney Neoplasms/pathology , Kidney Tubules , Aged , Humans , MaleABSTRACT
Report of one case of pure yolk sack testicular tumour in an adult patient. This was a stage I case which had been under observation for 3 years without further evidence of disease. Several aspects related with this type of germinal, non-seminomatous tumour of the testicle are commented upon.
Subject(s)
Endodermal Sinus Tumor , Testicular Neoplasms , Adult , Endodermal Sinus Tumor/pathology , Humans , Male , Testicular Neoplasms/pathologyABSTRACT
The role of systemic lupus erythematosus (SLE) in the development of acute pancreatitis is a matter of controversy since, in many cases, this complication has been attributed to the drugs administered. In this study, we present a patient diagnosed as having SLE who developed acute pancreatitis with no apparent cause aside from her basic disease, and in whose necropsy was observed vascular damage consisting of severe intimal proliferation. Pancreatic vascular lesions in previously reported patients with lupus are reviewed.
Subject(s)
Lupus Erythematosus, Systemic/complications , Pancreatitis/etiology , Acute Disease , Adult , Arteries/pathology , Female , Humans , Lupus Erythematosus, Systemic/pathology , Pancreas/blood supply , Pancreas/pathology , Pancreatitis/pathologyABSTRACT
A 44-year-old male was diagnosed in August 1980 as having a retroperitoneal germ cell tumor (classic seminoma with anaplastic areas). After treatment with cisplatin-based chemotherapy, he reached complete clinical and pathological remission. Eighty-eight months later, in December 1987, he was diagnosed as having a testicular mixed germ cell tumor (embryonal carcinoma with anaplastic seminoma areas) after right orchiectomy. The potential mechanisms by which the latter tumor could have developed are discussed.
