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1.
Ned Tijdschr Geneeskd ; 157(5): A5117, 2013.
Article in Dutch | MEDLINE | ID: mdl-23369813

ABSTRACT

In a newborn boy, a tumour was seen on the tongue and mandibula. A diagnosis of congenital epulis was made. This usually pedunculated tumour is present at birth and located on the maxillary or mandibular alveolar ridge (more commonly on the maxilla), but rarely on the tongue. It varies greatly in size from just a few millimetres in diameter to several centimetres. Treatment is only necessary when feeding problems occur.


Subject(s)
Alveolar Process , Gingival Neoplasms/congenital , Neoplasms, Multiple Primary/congenital , Tongue Neoplasms/congenital , Gingival Neoplasms/diagnosis , Humans , Infant, Newborn , Male , Neoplasms, Multiple Primary/diagnosis , Tongue Neoplasms/diagnosis
2.
Int Arch Allergy Immunol ; 130(4): 266-74, 2003 Apr.
Article in English | MEDLINE | ID: mdl-12740527

ABSTRACT

BACKGROUND: It remains to be established which factors contribute to the occurrence of asthma in allergic individuals. We hypothesized that differences in the late allergic inflammatory reaction to allergen between asthmatic and non-asthmatic house dust mite-allergic individuals might contribute to the difference in the clinical presentation of allergy. AIM: To compare allergen-induced changes in parameters for cellular inflammation during the phase of the late allergic reaction in the skin and nose, in house dust mite-allergic individuals with or without asthma. MATERIAL AND METHODS: Nasal and dermal allergen challenges with house dust mite (Dermatophagoides pteronyssinus) extract were performed in 52 house dust mite-allergic individuals, of whom 26 had mild to moderate persistent asthma and 26 had perennial rhinitis without current or past asthmatic symptoms. Serial nasal lavage samples were analyzed for the presence of inflammatory cells (eosinophils and neutrophils) and soluble markers associated with cellular inflammation [interleukin-5 (IL-5), interleukin-8 (IL-8), eosinophil cationic protein (ECP) and myeloperoxidase (MPO)]. Macroscopic late phase skin reactions were studied after intracutaneous skin tests with house dust mite extract. RESULTS: Fixed dose nasal allergen provocation elicited a similar degree of immediate allergic reaction as judged by plasma protein exudation and histamine concentrations in asthma and non-asthmatic rhinitis. Subsequently, no differences between groups were found during the phase of the late allergic reaction (4-24 h) in inflammatory cell influx, plasma protein leakage, ECP or MPO. Likewise, there were no differences in levels of chemotactic cytokines IL-5 and IL-8. In agreement with the results of nasal challenge, the late skin reaction after dermal challenge with a fixed allergen dose and after an allergen dose 10,000 times above the skin threshold for an early skin reaction did not differ between the groups. CONCLUSION: House dust mite-allergic patients with or without asthma have very similar late allergic inflammatory reactions in the skin and in the nose after allergen challenge. Hence, it is unlikely that the occurrence of pulmonary symptoms in asthma is explained by a general tendency of asthmatics to have an enhanced late allergic cellular inflammatory response. Nasal and dermal allergen provocations are adequate models to study allergen-induced inflammation but probably lack the pivotal link which is essential for the development of asthma.


Subject(s)
Allergens/immunology , Asthma/immunology , Inflammation/immunology , Pyroglyphidae/immunology , Rhinitis, Allergic, Perennial/immunology , Adolescent , Adult , Animals , Asthma/complications , Biomarkers/analysis , Female , Humans , Male , Nasal Lavage Fluid/chemistry , Nose/immunology , Rhinitis, Allergic, Perennial/complications , Skin/immunology
3.
Ann Allergy Asthma Immunol ; 89(6): 606-12, 2002 Dec.
Article in English | MEDLINE | ID: mdl-12487227

ABSTRACT

BACKGROUND: Activity of immunoglobulin (Ig)E-dependent histamine-releasing factor (HRF) is dependent on the IgE molecules bound to the surface of basophils. Sera capable of passively sensitizing basophils to release histamine to HRF were designated IgE+ sera. IgE+ and HRF have been suggested to play a role in late allergic reaction (LAR). OBJECTIVE: The working hypothesis was tested that IgE+ induces a LAR. Further, activity of HRF produced by mononuclear cells (HRF(mn)) was compared with that of recombinant HRF p23. METHODS: Atopic patients (n = 82) were bronchially provoked with Dermatophagoides pteronyssinus extract and the change in forced expiratory volume in 1 second was monitored. A LAR was defined as forced expiratory volume in 1 second as percentage of baseline < 80% 4 to 10 hours after allergen challenge. The presence of HRF-responsive IgE in serum was determined using basophils sensitized in vitro by serum. RESULTS: The presence of HRF(mn)-responsive IgE (IgE(mn+)) in serum was shown not be essential for a LAR: 63% of the patients with a LAR had no IgE(mn+) in their serum. Further, 71% of patients with IgE(mn+) did not have a LAR. HRF(mn) and recombinant HRF p23 were not equivalent in the bioassay: serum of 38 of 82 atopic patients sensitized basophils to release histamine to HRF(mn), whereas this was found with serum of 1 of 82 patients to HRF p23. CONCLUSIONS: The results do not support the hypothesis that IgE(mn+) induces a LAR, but do not exclude the alternative hypothesis that HRFs are released during a LAR and contribute to asthma severity.


Subject(s)
Antigens, Dermatophagoides , Basophils/metabolism , Biomarkers, Tumor , Bronchial Hyperreactivity/etiology , Bronchial Provocation Tests , Hypersensitivity, Delayed/etiology , Immunoglobulin E/blood , Monocytes/metabolism , Pyroglyphidae/immunology , Adolescent , Adult , Animals , Antigens, Dermatophagoides/adverse effects , Asthma/blood , Asthma/immunology , Basophils/immunology , Biomarkers, Tumor/metabolism , Biomarkers, Tumor/pharmacology , Bronchial Hyperreactivity/blood , Female , Histamine Release , Humans , Hypersensitivity, Delayed/blood , Hypersensitivity, Delayed/immunology , Hypersensitivity, Immediate/immunology , Male , Middle Aged , Radioallergosorbent Test , Recombinant Proteins/pharmacology , Skin Tests , Tumor Protein, Translationally-Controlled 1
4.
Metabolism ; 51(1): 57-64, 2002 Jan.
Article in English | MEDLINE | ID: mdl-11782873

ABSTRACT

In the liver, paracrine interaction between Kupffer cells and hepatocytes influences glucose metabolism. In vitro in rats, nitric oxide (NO), a paracrine mediator, inhibits several pathways of hepatic glucose production. The role of NO on glucose production has not been studied in vivo in humans. Glucose production was measured during N(G)-monomethyl-L-arginine, monoacetate salt (L-NMMA) infusion, an inhibitor of NO synthesis in vivo, in 6 healthy men fasting 23 hours in a saline-controlled crossover study. During L-NMMA infusion, NO output decreased 40% to 50%, peripheral vascular resistance increased approximately 22%, and cardiac output (CO) decreased approximately 14%. The decrease in glucose production was not different between L-NMMA and saline. Glucose concentration, substrate supply, and glucoregulatory hormone concentrations were not different; epinephrine was lower with L-NMMA. A 40% to 50% inhibition of NO synthesis in vivo in humans does not affect glucose production during short-term fasting. The hypothesis that NO is an important modulator of basal glucose production in healthy humans in vivo should therefore be rejected.


Subject(s)
Glucose/biosynthesis , Nitric Oxide/antagonists & inhibitors , Adult , Arginine/blood , Cross-Over Studies , Endocrine Glands/drug effects , Enzyme Inhibitors/blood , Enzyme Inhibitors/pharmacology , Glucose/metabolism , Hemodynamics/drug effects , Humans , Infusions, Intravenous , Male , Nitrates/blood , Nitric Oxide/biosynthesis , omega-N-Methylarginine/blood , omega-N-Methylarginine/pharmacology
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