ABSTRACT
AIM: To elicit the most sensitive and reliable method of control over administration of indirect anticoagulants. MATERIAL AND METHODS: Sixty patients with acute coronary syndrome were studied. They received varfarin under the control of international normalized ratio (INR) calculated by the tables in cases of prothrombin time (PT) estimation on a stationary turbidynamic hemocoagulometer from venous and capillary blood by thromboplastins. In parallel, PT was estimated from whole capillary blood on individual portable coagulometer "Coagu Check C" by means of standard test-strip (prothrombin test--PT) on the study day 1, 3, 5, 7, 14 and 21. The results were assessed on the study day 21. All the patients were treated in hospital then outpatiently. RESULTS: The assessment of PT results implied calculation of variation coefficient (VC) and error (m) by each index obtained with thromboplastins. VS and m were the lowest when INR was made from whole capillary blood on coagulometer "Coagu Check C". CONCLUSION: An optimal method of control over efficacy of varfarin treatment is calculation of INR from capillary blood on coagulometer "Coagu Check C" as calculation of INR from capillary and venous blood on stationary coagulometer is complicated and reliability depends on thromboplastin used.
Subject(s)
Anticoagulants/therapeutic use , Coronary Disease/blood , Coronary Disease/drug therapy , Warfarin/therapeutic use , Acute Disease , Adult , Aged , Blood Coagulation Tests , Female , Humans , International Normalized Ratio , Laboratories, Hospital , Male , Middle Aged , Partial Thromboplastin Time , Point-of-Care Systems , Prothrombin Time , Quality Assurance, Health Care , Quality Control , Reference Standards , Syndrome , Time FactorsSubject(s)
Endocrine System Diseases/complications , Hypertension/complications , Immune System Diseases/complications , Neurosecretory Systems/physiopathology , Pre-Eclampsia/etiology , Endocrine System Diseases/immunology , Endocrine System Diseases/physiopathology , Female , Humans , Hypertension/immunology , Hypertension/physiopathology , Immune System Diseases/immunology , Immune System Diseases/physiopathology , Neurosecretory Systems/immunology , Pre-Eclampsia/immunology , Pre-Eclampsia/physiopathology , PregnancyABSTRACT
The features of histories, course of pregnancy and delivery were analyzed in 65 females with hypotonic bleeding developed during cesarean section. The bleeding resulted in uterine extirpation. The factors that predisposed to the abnormality were revealed. Morphological examination of uterine specimens demonstrated that in 95% hypotonic bleedings had been due to profound pathomorphological changes in the myometrium as ones occurred prior to pregnancy and developed during pregnancy and labor. Accordingly, long-term and ineffective treatment of hypotonic bleeding is frequently unfounded as in most cases only ablation of the uterus may be the sole means of hemostasis.
