Abscesso hepático por Klebsiella pneumoniae e suas complicações sistêmicas / Liver abscess by Klebsiella pneumoniae and its systemic complication

Abscesso hepático por Klebsiella pneumoniae é incomum em países ocidentais e tem sido associado a complicações severas, sobretudo em pacientes diabéticos. A manifestação clínico-laboratorial da doença é inespecífica. Endoftalmite é uma rara complicação de septicemia por Klebsiella pneumoniae. Atraso terapêutico pode resultar em perda visual acentuada e irreversível. Relatamos um caso de abscesso hepático por Klebsiella pneumoniae complicado com endoftalmite, embolia pulmonar séptica e endocardite em homem diabético.

Klebsiella pneumoniae liver abscess is unco mmon in western countries and has been associated with severe complications, especially in diabetic patients. The clinical and laboratory manifestations of the disease are nonspecific. Endophthalmitis is a rare complication of septicemia due to Klebsiella pneumoniae. Therapeutic delay can result in severe and irreversible visual loss. We report a case of Klebsiella pneumoniae liver abscess complicated by endophthalmitis, septic pulmonary emboli and endocarditis in diabetic man.

Metabolic syndrome is an independent risk factor for breast cancer.

OBJECTIVE: This study was aimed to assess the prevalence of metabolic syndrome in patients with breast cancer and the independent effect of metabolic syndrome on breast cancer risk. METHODS: Eighty-one women aged 40-80 years with breast cancer and 81 controls of similar age were screened for metabolic syndrome prevalence and breast cancer risk factors, including age at diagnosis, age at menarche, reproductive status, live births, breastfeeding, family history of breast cancer, physical activity, cigarette smoking, body mass index, and metabolic syndrome parameters. Each variable was first assessed for baseline comparisons using the univariate model, and significant variables were then added to the multivariate conditional logistic regression model. RESULTS: Prevalence of metabolic syndrome was 59.2% in breast cancer patients, and 37% in the control group (p < 0.005). A positive and independent association was observed between metabolic syndrome and breast cancer risk (odds ratio = 2.49; 95% confidence interval 1.17-5.30). CONCLUSION: Metabolic syndrome is more prevalent in breast cancer patients and is an independent risk factor for breast cancer.