Whose Voices Are Heard? Speaker Gender Representation at the Society of Cardiovascular Anesthesiologists Annual Meeting.

OBJECTIVE: Gender disparities in academic medicine continue to be prevalent despite significant advances in the number of women entering medicine over the last decades. The purpose of the present study was to investigate gender representation of speakers at Society of Cardiovascular Anesthesiologists (SCA) Annual Scientific Sessions meetings from 2015 to 2018. DESIGN: Observational study. SETTING: Internet analysis and cross-sectional survey. PARTICIPANTS: Speakers at the SCA Annual Scientific Sessions meetings from 2015 to 2018. INTERVENTIONS: Individual speakers in the main program, problem-based learning discussions, workshops, and fellow sessions were analyzed for speaker gender. Speakers' names, pronouns, institutional biographies, and accompanying images were matched with public online data and were used to identify gender. Gender data from the 2019 SCA Diversity Survey respondents were used to estimate gender of the SCA membership. MEASUREMENTS AND MAIN RESULTS: Between 2015 and 2018, the number of lectures given by women was 22% to 25%. A statistically significant difference was found in the expected versus observed proportion of women in speaking slots for all combined sessions (2015-2018; p = 0.0027, 0.0023, 0.0018, 0.025, respectively). There also was a statistically significant difference in the expected versus observed proportion of women in speaking slots in the main sessions (2015-2018; p ≤ 0.0001, 0.00069, 0.00019, 0.00019, respectively). For the workshops, problem-based learning discussions, and fellow sessions, no statistically significant difference was found in the observed versus expected proportion of women in speaker slots. CONCLUSIONS: Between 2015 and 2018, the majority of lectures at the SCA annual meetings were given by men, with women consistently giving 22% to 25% of individual lectures. When all sessions were combined, there was a statistically significant difference in the expected versus observed proportion of women in speaking slots.

A brain slice culture model of viral encephalitis reveals an innate CNS cytokine response profile and the therapeutic potential of caspase inhibition.

Viral encephalitis is a significant cause of human morbidity and mortality in large part due to suboptimal diagnosis and treatment. Murine reovirus infection serves as a classic experimental model of viral encephalitis. Infection of neonatal mice with T3 reoviruses results in lethal encephalitis associated with neuronal infection, apoptosis, and CNS tissue injury. We have developed an ex vivo brain slice culture (BSC) system that recapitulates the basic pathological features and kinetics of viral replication seen in vivo. We utilize the BSC model to identify an innate, brain-tissue specific inflammatory cytokine response to reoviral infection, which is characterized by the release of IL6, CXCL10, RANTES, and murine IL8 analog (KC). Additionally, we demonstrate the potential utility of this system as a pharmaceutical screening platform by inhibiting reovirus-induced apoptosis and CNS tissue injury with the pan-caspase inhibitor, Q-VD-OPh. Cultured brain slices not only serve to model events occurring during viral encephalitis, but can also be utilized to investigate aspects of pathogenesis and therapy that are not experimentally accessible in vivo.