ABSTRACT
Male Wistar rats were socially isolated from the 17th day of birth. Ventral tegmental area (VTA) of a half of the 17th-day rats was unilaterally damaged with intrastructural administration of kainic acid. In adult rats (both raised in groups and in isolation) amphetamine (1 mg/kg) facilitated self-stimulation of the lateral hypothalamus (by 37%). Social isolation increased the sensitivity of dopaminergic system only in rats with VTA lesions which was manifested in promoting self-stimulation after administration of amphetamine, though the level and turnover of tegmental dopamine was decreased. 6-Hydroxydopamine (75 mcg intracisternally), a catecholaminergic neurotoxin, significantly inhibited self-stimulation in isolated rats and decreased catecholamine levels in the lateral hypothalamus. The neurotoxic effect of 6-hydroxydopamine was abolished by amphetamine, probably, owing to enhancement of the functional activity of parabiotically living neuronal structures of the mesocorticolimbic dopaminergic system of the brain.
Subject(s)
Brain/drug effects , Dopamine Agents/pharmacology , Dopamine/metabolism , Hypothalamic Area, Lateral/drug effects , Self Stimulation/drug effects , Social Isolation , Ventral Tegmental Area/physiology , Amphetamine/pharmacology , Animals , Brain/metabolism , Brain Chemistry/drug effects , Dopamine/analysis , Electric Stimulation , Electrodes, Implanted , Hypothalamic Area, Lateral/chemistry , Hypothalamic Area, Lateral/physiology , Kainic Acid , Male , Oxidopamine/pharmacology , Rats , Rats, Wistar , Self Stimulation/physiology , Ventral Tegmental Area/drug effectsABSTRACT
Unilateral impairments of brain led to appearance of posture asymmetry factors (PAF) in central nervous system, which caused asymmetric function of spinal centers and were responsible for asymmetry of limb muscular tension. During compensation symmetrization of muscular tension was followed by inactivation of PAF using developed in central nervous system antifactors which formed complexes with PAF. These factors of inactivation proved to be thermolabile proteins partially involving IgG. Administration of immunomodulator "Gradex B" into postoperation animals stimulated distinctly restoration of arbitrary movements in impaired limbs. The data obtained suggest that immune system is of importance in control of endogenous substances activity, which are produced in central nervous system; a novel procedure was studied for correction of locomotory impairments of central genesis.
Subject(s)
Functional Laterality , Immune System/physiopathology , Movement Disorders/etiology , Animals , Male , Mice , Molecular Weight , Neuropeptides/antagonists & inhibitors , Neuropeptides/blood , Neuropeptides/cerebrospinal fluid , Tissue Extracts/metabolismABSTRACT
The effect of the CSF components of the rats who had restored motor deficiency after left unilateral removal of motor neocortex, was studied in the rats with an analogous brain lesion. The first group of animals received a thermostable fraction of the donor CSF containing active factors of the posture asymmetry (FPA). The second group of animals were given a high-molecular fraction of the donor CSF with active factors inactivating the FPA. The first group revealed a significant acceleration of compensatory processes. Only a temporary positive effect was observed in the second group. The findings can be used in neurological clinics when treating motor disorders of central genesis.
Subject(s)
Brain Injuries/cerebrospinal fluid , Cerebrospinal Fluid/physiology , Movement Disorders/cerebrospinal fluid , Animals , Biopolymers , Brain Injuries/drug therapy , Brain Injuries/physiopathology , Cerebrospinal Fluid Proteins/isolation & purification , Cerebrospinal Fluid Proteins/therapeutic use , Convalescence , Dominance, Cerebral/drug effects , Dominance, Cerebral/physiology , Drug Evaluation, Preclinical , Male , Molecular Weight , Motor Cortex/injuries , Movement Disorders/drug therapy , Movement Disorders/physiopathology , Posture/physiology , RatsABSTRACT
The responses of the cat's collicular neurons to direct stimulation (DCR) of contralateral neocortex were studied in various periods after unilateral dissection of cortico-subcortical connections. The data obtained suggest that, in intact cat's brain, during early hours of postoperative period, and within 1-2 years after the operation, functional specifics of contralateral motor and sensory projections to superior colliculus played a major part in determining basic features of compensatory shifts of the impulse activity of collicular neurons.
Subject(s)
Cerebral Cortex/physiology , Superior Colliculi/physiology , Adaptation, Physiological , Afferent Pathways/physiology , Animals , Cats , Decerebrate State/physiopathology , Dominance, Cerebral/physiology , Electric Stimulation , Microelectrodes , Motor Cortex/physiology , Neurons/physiology , Time FactorsABSTRACT
Recipient rats with unilateral ablation of the motor cortex underwent suboccipital injection of the CSF obtained from donor rats with analogous damages of their motor cortex. The dose 150 microliter of the donor CSF was most effective rendering a considerable improvement of motor functions in the recipient rats. The data obtained suggest an essentially new technique of human brain trauma therapy using injections of donor CSF.
