ABSTRACT
Experiments on 350 Wistar rats receiving single i. p. doses of 238Pu and 239Pu citrate (pH 6.5) have shown that 0.73-0.84% of the administered nuclides respectively are excreted with urine on the 1st day. By the end of the study (128-260 th day) the excretion value gets stable and equals 0.013-0.018%. Change of the radionuclide excretion natural rate is described in 3 exponential equations. A significantly greater rate of 238Pu excretion was revealed as compared to that of 239Pu excretion over the period of the 2nd-35th day. Intravenous injection of pentacin at a dose of 25 mu mol/kg in one of the above periods (0.5 h, 1; 8; 32; 128 and 256th day) after administration of the nuclides enhances their excretion with urine. On administering the complex after 0.5 h radionuclide excretion was maximum (16.7-20.0%).
