ABSTRACT
We used intravenously administered 99mTc-labelled macroaggregates and a gamma camera attached to a computer for measuring distribution of pulmonary blood flow per unit lung volume in eight healthy subjects sitting erect in air and also during breathhold diving to 1 or 10 m of depth. We measured distribution of perfusion in the supine position and substituted regional lung volume with regional perfusion in the supine for calculating regional perfusion per lung volume erect in air and during diving. The perfusion per unit lung increased rectilinearly down the lung in subjects below 30 years of age but decreased in the lowermost regions in older subjects. This decrease showed a strong correlation to closing capacity. An age-related decrease in transpulmonary pressure may influence both basal perfusion and closing capacity. During submersion, perfusion became equal in all regions with the exception of the lung apex which became hyperperfused. Close to the diaphragm, small inconsistent changes were noted. Redistribution was the same at surface (1 m of depth) with the lung volume being close to total lung capacity and at 10 m of depth when lung volume was compressed to functional residual capacity. During breathhold diving, high intrapulmonary blood volume and pressure became more important for blood flow distribution than gravity or lung volume, while differences in regional hypoxic vasoconstriction and in transpulmonary pressure seem to explain interindividual variation.
