Partial sternectomy with reconstruction of a giant cell tumor of the sternum, a case report, Saudi, Arabia.

BACKGROUND: Giant cell tumor (GCT) is a relatively common and locally aggressive benign bone tumor that rarely affects the sternum. CASE PRESENTATION: We report a case of giant cell tumor of the sternum in a 28-year-old Saudi with painful swelling at the lower part of the sternum. Subtotal sternectomy and reconstruction with a neosternum using two layers of proline mesh, a methyl methacrylate prosthesis, and bilateral pectoralis muscle advancement flaps were performed. CONCLUSIONS: Giant cell tumor of the sternum is a rare diagnosis. Surgical resection with negative margins is the ideal management. To avoid defects or instability of the chest wall, reconstruction of the chest wall with neosternum should be considered.

Early Detection of Alzheimer's Disease From Cortical and Hippocampal Local Field Potentials Using an Ensembled Machine Learning Model.

Early diagnosis of Alzheimer's disease (AD) is a very challenging problem and has been attempted through data-driven methods in recent years. However, considering the inherent complexity in decoding higher cognitive functions from spontaneous neuronal signals, these data-driven methods benefit from the incorporation of multimodal data. This work proposes an ensembled machine learning model with explainability (EXML) to detect subtle patterns in cortical and hippocampal local field potential signals (LFPs) that can be considered as a potential marker for AD in the early stage of the disease. The LFPs acquired from healthy and two types of AD animal models (n = 10 each) using linear multielectrode probes were endorsed by electrocardiogram and respiration signals for their veracity. Feature sets were generated from LFPs in temporal, spatial and spectral domains and were fed into selected machine-learning models for each domain. Using late fusion, the EXML model achieved an overall accuracy of 99.4%. This provided insights into the amyloid plaque deposition process as early as 3 months of the disease onset by identifying the subtle patterns in the network activities. Lastly, the individual and ensemble models were found to be robust when evaluated by randomly masking channels to mimic the presence of artefacts.

ABOT: an open-source online benchmarking tool for machine learning-based artefact detection and removal methods from neuronal signals.

Brain signals are recorded using different techniques to aid an accurate understanding of brain function and to treat its disorders. Untargeted internal and external sources contaminate the acquired signals during the recording process. Often termed as artefacts, these contaminations cause serious hindrances in decoding the recorded signals; hence, they must be removed to facilitate unbiased decision-making for a given investigation. Due to the complex and elusive manifestation of artefacts in neuronal signals, computational techniques serve as powerful tools for their detection and removal. Machine learning (ML) based methods have been successfully applied in this task. Due to ML's popularity, many articles are published every year, making it challenging to find, compare and select the most appropriate method for a given experiment. To this end, this paper presents ABOT (Artefact removal Benchmarking Online Tool) as an online benchmarking tool which allows users to compare existing ML-driven artefact detection and removal methods from the literature. The characteristics and related information about the existing methods have been compiled as a knowledgebase (KB) and presented through a user-friendly interface with interactive plots and tables for users to search it using several criteria. Key characteristics extracted from over 120 articles from the literature have been used in the KB to help compare the specific ML models. To comply with the FAIR (Findable, Accessible, Interoperable and Reusable) principle, the source code and documentation of the toolbox have been made available via an open-access repository.

Systematic review on modification to the ad-hoc on-demand distance vector routing discovery mechanics.

Mobile ad-hoc networks (MANETs) and wireless mesh networks (WMNs) are used in a variety of research areas, including the military, industry, healthcare, agriculture, the Internet of Things (IoT), transportation, and smart cities. The swift advancement in MANET technology is the driving force behind this rising adoption rate. Routing over MANET is a critical problem due to the dynamic nature of the link qualities, even when nodes are static. A key challenge in MANETs is the need for an efficient routing protocol that establishes a route according to certain performance metrics related to the link quality. The routing protocols utilised by the nodes in WMNs and MANETs are distinct. Nodes in both types of networks exchange data packets through the routing protocols. For this highly mobile network, the ad-hoc On-Demand Distance Vector (AODV) routing protocol has been suggested as a possible solution. Recent years have attracted researchers' attention to AODV since it is a routing technique for ad-hoc networks that prevents looping. The architecture of this routing protocol considers several factors, including the mobility of nodes, the failure of connection links, and the loss of packets. In this systematic review, one of the key focuses is bringing attention to the classic AODV, which was developed after discussing the recent development of several versions of AODV. The AODV routing protocol performs a path strength check to generate a more reliable and secure route between the source and destination nodes. In AODV, investigations demonstrate advances in both the format protocol approach and the network simulation-2 (NS-2), and these improvements were made in the same scenario used to revitalise AODV. It has been discovered that the AODV is more effective in several aspects, such as throughput, end-to-end delay, packet delivery ratio (PDR), energy consumption, jitter, packet loss ratio, and network overhead. Furthermore, this paper presents this systematic review based on AODV modifications in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). It also provides a methodological framework for the papers' selection.

Channel-independent recreation of artefactual signals in chronically recorded local field potentials using machine learning.

Acquisition of neuronal signals involves a wide range of devices with specific electrical properties. Combined with other physiological sources within the body, the signals sensed by the devices are often distorted. Sometimes these distortions are visually identifiable, other times, they overlay with the signal characteristics making them very difficult to detect. To remove these distortions, the recordings are visually inspected and manually processed. However, this manual annotation process is time-consuming and automatic computational methods are needed to identify and remove these artefacts. Most of the existing artefact removal approaches rely on additional information from other recorded channels and fail when global artefacts are present or the affected channels constitute the majority of the recording system. Addressing this issue, this paper reports a novel channel-independent machine learning model to accurately identify and replace the artefactual segments present in the signals. Discarding these artifactual segments by the existing approaches causes discontinuities in the reproduced signals which may introduce errors in subsequent analyses. To avoid this, the proposed method predicts multiple values of the artefactual region using long-short term memory network to recreate the temporal and spectral properties of the recorded signal. The method has been tested on two open-access data sets and incorporated into the open-access SANTIA (SigMate Advanced: a Novel Tool for Identification of Artefacts in Neuronal Signals) toolbox for community use.

Task-Oriented Intelligent Solution to Measure Parkinson's Disease Tremor Severity.

Tremor is a common symptom of Parkinson's disease (PD). Currently, tremor is evaluated clinically based on MDS-UPDRS Rating Scale, which is inaccurate, subjective, and unreliable. Precise assessment of tremor severity is the key to effective treatment to alleviate the symptom. Therefore, several objective methods have been proposed for measuring and quantifying PD tremor from data collected while patients performing scripted and unscripted tasks. However, up to now, the literature appears to focus on suggesting tremor severity classification methods without discrimination tasks effect on classification and tremor severity measurement. In this study, a novel approach to identify a recommended system is used to measure tremor severity, including the influence of tasks performed during data collection on classification performance. The recommended system comprises recommended tasks, classifier, classifier hyperparameters, and resampling technique. The proposed approach is based on the above-average rule of five advanced metrics results of four subdatasets, six resampling techniques, six classifiers besides signal processing, and features extraction techniques. The results of this study indicate that tasks that do not involve direct wrist movements are better than tasks that involve direct wrist movements for tremor severity measurements. Furthermore, resampling techniques improve classification performance significantly. The findings of this study suggest that a recommended system consists of support vector machine (SVM) classifier combined with BorderlineSMOTE oversampling technique and data collection while performing set of recommended tasks, which are sitting, stairs up and down, walking straight, walking while counting, and standing.

SANTIA: a Matlab-based open-source toolbox for artifact detection and removal from extracellular neuronal signals.

Neuronal signals generally represent activation of the neuronal networks and give insights into brain functionalities. They are considered as fingerprints of actions and their processing across different structures of the brain. These recordings generate a large volume of data that are susceptible to noise and artifacts. Therefore, the review of these data to ensure high quality by automatically detecting and removing the artifacts is imperative. Toward this aim, this work proposes a custom-developed automatic artifact removal toolbox named, SANTIA (SigMate Advanced: a Novel Tool for Identification of Artifacts in Neuronal Signals). Developed in Matlab, SANTIA is an open-source toolbox that applies neural network-based machine learning techniques to label and train models to detect artifacts from the invasive neuronal signals known as local field potentials.

Towards human distance estimation using a thermal sensor array.

Human distance estimation is essential in many vital applications, specifically, in human localisation-based systems, such as independent living for older adults applications, and making places safe through preventing the transmission of contagious diseases through social distancing alert systems. Previous approaches to estimate the distance between a reference sensing device and human subject relied on visual or high-resolution thermal cameras. However, regular visual cameras have serious concerns about people's privacy in indoor environments, and high-resolution thermal cameras are costly. This paper proposes a novel approach to estimate the distance for indoor human-centred applications using a low-resolution thermal sensor array. The proposed system presents a discrete and adaptive sensor placement continuous distance estimators using classification techniques and artificial neural network, respectively. It also proposes a real-time distance-based field of view classification through a novel image-based feature. Besides, the paper proposes a transfer application to the proposed continuous distance estimator to measure human height. The proposed approach is evaluated in different indoor environments, sensor placements with different participants. This paper shows a median overall error of ± 0.2  m in continuous-based estimation and 96.8 % achieved-accuracy in discrete distance estimation.

An Entropy-Based Approach for Anomaly Detection in Activities of Daily Living in the Presence of a Visitor.

This paper presents anomaly detection in activities of daily living based on entropy measures. It is shown that the proposed approach will identify anomalies when there are visitors representing a multi-occupant environment. Residents often receive visits from family members or health care workers. Therefore, the residents' activity is expected to be different when there is a visitor, which could be considered as an abnormal activity pattern. Identifying anomalies is essential for healthcare management, as this will enable action to avoid prospective problems early and to improve and support residents' ability to live safely and independently in their own homes. Entropy measure analysis is an established method to detect disorder or irregularities in many applications: however, this has rarely been applied in the context of activities of daily living. An experimental evaluation is conducted to detect anomalies obtained from a real home environment. Experimental results are presented to demonstrate the effectiveness of the entropy measures employed in detecting anomalies in the resident's activity and identifying visiting times in the same environment.

Parkinson's disease: current assessment methods and wearable devices for evaluation of movement disorder motor symptoms - a patient and healthcare professional perspective.

BACKGROUND: Parkinson's disease is the second most common long-term chronic, progressive, neurodegenerative disease, affecting more than 10 million people worldwide. There has been a rising interest in wearable devices for evaluation of movement disorder diseases such as Parkinson's disease due to the limitations in current clinic assessment methods such as Unified Parkinson's Disease Rating Scale (UPDRS) and the Hoehn and Yahr (HY) scale. However, there are only a few commercial wearable devices available, which, in addition, have had very limited adoption and implementation. This inconsistency may be due to a lack of users' perspectives in terms of device design and implementation. This study aims to identify the perspectives of healthcare professionals and patients linked to current assessment methods and to identify preferences, and requirements of wearable devices. METHODS: This was a qualitative study using semi-structured interviews followed by focus groups. Transcripts from sessions were analysed using an inductive thematic approach. RESULTS: It was noted that the well-known assessment process such as Unified Parkinson's Disease Rating Scale (UPDRS) was not used routinely in clinics since it is time consuming, subjective, inaccurate, infrequent and dependent on patients' memories. Participants suggested that objective assessment methods are needed to increase the chance of effective treatment. The participants' perspectives were positive toward using wearable devices, particularly if they were involved in early design stages. Patients emphasized that the devices should be comfortable, but they did not have any concerns regarding device visibility or data privacy transmitted over the internet when it comes to their health. In terms of wearing a monitor, the preferable part of the body for all participants was the wrist. Healthcare professionals stated a need for an economical solution that is easy to interpret. Some design aspects identified by patients included clasps, material choice, and form factor. CONCLUSION: The study concluded that current assessment methods are limited. Patients' and healthcare professionals' involvement in wearable devices design process has a pivotal role in terms of ultimate user acceptance. This includes the provision of additional functions to the wearable device, such as fall detection and medication reminders, which could be attractive features for patients.

A novel deep mining model for effective knowledge discovery from omics data.

Knowledge discovery from omics data has become a common goal of current approaches to personalised cancer medicine and understanding cancer genotype and phenotype. However, high-throughput biomedical datasets are characterised by high dimensionality and relatively small sample sizes with small signal-to-noise ratios. Extracting and interpreting relevant knowledge from such complex datasets therefore remains a significant challenge for the fields of machine learning and data mining. In this paper, we exploit recent advances in deep learning to mitigate against these limitations on the basis of automatically capturing enough of the meaningful abstractions latent with the available biological samples. Our deep feature learning model is proposed based on a set of non-linear sparse Auto-Encoders that are deliberately constructed in an under-complete manner to detect a small proportion of molecules that can recover a large proportion of variations underlying the data. However, since multiple projections are applied to the input signals, it is hard to interpret which phenotypes were responsible for deriving such predictions. Therefore, we also introduce a novel weight interpretation technique that helps to deconstruct the internal state of such deep learning models to reveal key determinants underlying its latent representations. The outcomes of our experiment provide strong evidence that the proposed deep mining model is able to discover robust biomarkers that are positively and negatively associated with cancers of interest. Since our deep mining model is problem-independent and data-driven, it provides further potential for this research to extend beyond its cognate disciplines.

Exploring Entropy Measurements to Identify Multi-Occupancy in Activities of Daily Living.

Human Activity Recognition (HAR) is the process of automatically detecting human actions from the data collected from different types of sensors. Research related to HAR has devoted particular attention to monitoring and recognizing the human activities of a single occupant in a home environment, in which it is assumed that only one person is present at any given time. Recognition of the activities is then used to identify any abnormalities within the routine activities of daily living. Despite the assumption in the published literature, living environments are commonly occupied by more than one person and/or accompanied by pet animals. In this paper, a novel method based on different entropy measures, including Approximate Entropy (ApEn), Sample Entropy (SampEn), and Fuzzy Entropy (FuzzyEn), is explored to detect and identify a visitor in a home environment. The research has mainly focused on when another individual visits the main occupier, and it is, therefore, not possible to distinguish between their movement activities. The goal of this research is to assess whether entropy measures can be used to detect and identify the visitor in a home environment. Once the presence of the main occupier is distinguished from others, the existing activity recognition and abnormality detection processes could be applied for the main occupier. The proposed method is tested and validated using two different datasets. The results obtained from the experiments show that the proposed method could be used to detect and identify a visitor in a home environment with a high degree of accuracy based on the data collected from the occupancy sensors.

An Entropy-Guided Monte Carlo Tree Search Approach for Generating Optimal Container Loading Layouts.

In this paper, a novel approach to the container loading problem using a spatial entropy measure to bias a Monte Carlo Tree Search is proposed. The proposed algorithm generates layouts that achieve the goals of both fitting a constrained space and also having "consistency" or neatness that enables forklift truck drivers to apply them easily to real shipping containers loaded from one end. Three algorithms are analysed. The first is a basic Monte Carlo Tree Search, driven only by the principle of minimising the length of container that is occupied. The second is an algorithm that uses the proposed entropy measure to drive an otherwise random process. The third algorithm combines these two principles and produces superior results to either. These algorithms are then compared to a classical deterministic algorithm. It is shown that where the classical algorithm fails, the entropy-driven algorithms are still capable of providing good results in a short computational time.

Human Movement Recognition Based on the Stochastic Characterisation of Acceleration Data.

Human activity recognition algorithms based on information obtained from wearable sensors are successfully applied in detecting many basic activities. Identified activities with time-stationary features are characterised inside a predefined temporal window by using different machine learning algorithms on extracted features from the measured data. Better accuracy, precision and recall levels could be achieved by combining the information from different sensors. However, detecting short and sporadic human movements, gestures and actions is still a challenging task. In this paper, a novel algorithm to detect human basic movements from wearable measured data is proposed and evaluated. The proposed algorithm is designed to minimise computational requirements while achieving acceptable accuracy levels based on characterising some particular points in the temporal series obtained from a single sensor. The underlying idea is that this algorithm would be implemented in the sensor device in order to pre-process the sensed data stream before sending the information to a central point combining the information from different sensors to improve accuracy levels. Intra- and inter-person validation is used for two particular cases: single step detection and fall detection and classification using a single tri-axial accelerometer. Relevant results for the above cases and pertinent conclusions are also presented.

L1 and L2 Spoken Word Processing: Evidence from Divided Attention Paradigm.

The present study aims to reveal some facts concerning first language (L1) and second language (L2) spoken-word processing in unbalanced proficient bilinguals using behavioral measures. The intention here is to examine the effects of auditory repetition word priming and semantic priming in first and second languages of these bilinguals. The other goal is to explore the effects of attention manipulation on implicit retrieval of perceptual and conceptual properties of spoken L1 and L2 words. In so doing, the participants performed auditory word priming and semantic priming as memory tests in their L1 and L2. In a half of the trials of each experiment, they carried out the memory test while simultaneously performing a secondary task in visual modality. The results revealed that effects of auditory word priming and semantic priming were present when participants processed L1 and L2 words in full attention condition. Attention manipulation could reduce priming magnitude in both experiments in L2. Moreover, L2 word retrieval increases the reaction times and reduces accuracy on the simultaneous secondary task to protect its own accuracy and speed.