ABSTRACT
The purpose of the experimental work was to study the effect of constant light, depending on the time of the onset of light exposure (from the age of one month or from fourteen months), on the development of age-related pathology and oncology in male rats. The results of the study show that decreased functional activity of the epiphysis due to the influence of constant light from the age of one month increases the incidence of inflammatory, non-tumor and tumor genesis diseases, and leads to the rapid development of age-related pathology. On the contrary, the onset of constant light exposure in male rats from the age of 14 months slows the development of age-related pathology, reduces the incidence and development of malignant tumors.
Subject(s)
Aging/pathology , Environmental Exposure/adverse effects , Light/adverse effects , Mortality/trends , Neoplasms/epidemiology , Animals , Environmental Exposure/statistics & numerical data , Male , RatsABSTRACT
The effect of different light conditions (constant illumination, light deprivation, the standard regime of lighting and natural for Northwest Russia lighting in different seasons of the annual cycle) on indicators of biological age and homeostasis, the development of age-related pathology, oncogenesis and longevity of rats was investigated. Exposure to constant light on the studied parameters was evaluated at different ages--antenatal, early and late postnatal period. The data about influences of substances and hormones of pineal gland on biomarkers of aging, homeostasis, spontaneous oncogenesis and longevity in experimental animals was obtained. It has been established that the light pollution and disturbance of photoperiod lead to desynchronosys and as a result to premature aging of the organism and age associated diseases. Ways of preventing accelerated aging were outlined.
Subject(s)
Aging, Premature , Aging , Antioxidants/metabolism , Light/adverse effects , Lighting , Melatonin/metabolism , Aging/physiology , Aging/radiation effects , Aging, Premature/etiology , Aging, Premature/metabolism , Aging, Premature/prevention & control , Animals , Humans , Lighting/adverse effects , Lighting/methods , Longevity/radiation effects , Models, Animal , Photobiology/methods , Photoperiod , Rats , Risk Assessment , Risk Factors , Russia , Seasons , Sleep Disorders, Circadian Rhythm/etiology , Sleep Disorders, Circadian Rhythm/metabolism , Sleep Disorders, Circadian Rhythm/prevention & controlABSTRACT
The influence of constant lightening on biomarkers of ageing and rates of male rats aging was studied. It was revealed that the maintenance of rats in the constant lightening regime starting from the age of one month results in accelerated ageing of the organism, the reduction of the phases progressive and stable growth, early occurrence of presenile and senile periods, to the earlier occurrence of water-and-salt metabolism imbalance, accelerate the process of "aging" of the antioxidant system in comparison with the rates of the control group. On the contrary, the maintenance of rats in the constant lightening regime starting from the age of fourteen months slows ageing of the organism, increases body growth, delays appearance of pathological changes in the urine, slows down the "aging" of the enzymatic components of the antioxidant system.
Subject(s)
Aging/physiology , Diuresis/physiology , Photoperiod , Animals , Body Weight , Catalase/metabolism , Homeostasis , Lighting , Male , Rats , Superoxide Dismutase/metabolism , Time FactorsABSTRACT
The influence of the duration of daylight in the condition of natural lightning in the North-West part of Russia on the dynamics of parameters of biological age in male rats according to the season of birth had been studied during two years. It was found out that alteration of the duration of daylight regardless of the male rats season of birth modified rate of sexual maturation, growth, weight, food and water consumption, daily urine output and blood glucose compared with the analogous parameters in the condition of standard light and dark interchange.
