ABSTRACT
AIM: To investigate whether imprint cytology from ultrasound-guided core biopsy specimens was adequate for the National Health Service Breast Screening Programme (NHSBSP) guidelines. METHODS: We prospectively audited imprint cytology from ultrasound-guided core biopsy specimens. The performance indicators for imprint cytology specimens from 111 consecutive ultrasound-guided core biopsy were compared with standards set by the NHSBSP for fine-needle aspiration cytology (FNAC). RESULTS: Imprint cytology fulfilled the "preferred" targets for absolute and complete sensitivity, specificity, positive predictive value, false-positive and false-negative rates, inadequate rate and inadequate rate from cancers. It also satisfied the minimum target for suspicious rate. The complete sensitivity was 97%, full specificity 78%, with 100% positive predictive value for C5 cytology and an inadequate rate from cancers of 1.5%. CONCLUSION: Imprint cytology from ultrasound-guided core biopsy allows same-day diagnosis and the collection of data regarding the grade of the carcinoma for treatment decisions from a single needle test.
Subject(s)
Breast Diseases/pathology , Breast/pathology , Biopsy, Needle/standards , Breast Neoplasms/pathology , Carcinoma, Ductal, Breast/pathology , Carcinoma, Lobular/pathology , Female , Humans , Middle Aged , Prospective Studies , Sensitivity and Specificity , Ultrasonography, InterventionalABSTRACT
BACKGROUND: The role of fine-needle aspiration cytology (FNAC) in the diagnosis and management of discrete parotid swellings remains controversial. Controlled enucleation can be appropriate with accurate preoperative diagnosis. This study (1985-1995) reviewed the role of FNAC in the diagnosis and surgical management of adenolymphoma. METHODS: Review of cytological smears by two observers concentrated on the features of infarction and squamoid metaplasia. Sensitivity, interobserver and intraobserver variation were evaluated statistically in a two-run 'blinded' analysis of 80 cytological slides from a variety of lesions. RESULTS: Of 222 epithelial neoplasms of the parotid, 33 were adenolymphomas. FNAC was performed before operation in 32, producing 34 slides, and a correct cytological diagnosis was made in 21 patients. Retrospective review of the 34 slides, to examine specific features of squamoid metaplasia and infarction, improved diagnostic accuracy. The reliability and reproducibility of cytodiagnosis was confirmed by analysis of interobserver and intraobserver agreement. The sensitivity was high (0.76-0.88). Controlled enucleation was performed in 12 patients and superficial parotidectomy in 11. There were no tumour recurrences. CONCLUSION: Attention to the features of squamoid metaplasia and infarction improves cytological diagnosis and directs appropriate surgical management.
Subject(s)
Adenolymphoma/pathology , Parotid Neoplasms/pathology , Adenolymphoma/surgery , Adult , Aged , Biopsy, Needle/adverse effects , Biopsy, Needle/methods , Female , Follow-Up Studies , Humans , Male , Middle Aged , Observer Variation , Parotid Neoplasms/surgery , Sensitivity and SpecificityABSTRACT
A retrospective survey to study vascular abnormalities was conducted on 1073 lymph nodes from 250 patients. Two haemangiomatoid lesions, found in axillary lymph nodes, are described. They are uncommon, localised lesions which appear to be associated with local malignancy. A more frequent vascular abnormality was pan-nodal vasodilatation, which tends to affect many nodes in a single group and is especially associated with ulcerative colitis. Both types of lesion appear to be reactive in nature. Their characteristics suggest responses to different stimuli.
