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1.
Occurrence of aflatoxins in human foodstuffs in South Africa.
Lötter, L H; Kröhm, H J.
Bull Environ Contam Toxicol ; 40(2): 240-3, 1988 Feb.
Article in English | MEDLINE | ID: mdl-3349195

Subject(s)
Aflatoxins/analysis , Food Contamination/analysis , Humans , South Africa
2.
Inter-laboratory calibration for the quality control of pesticide residue analyses (1984-85).
de Beer, P R; van Dyk, L P; Prinsloo, S M; Viljoen, A J; Lotter, L H.
Analyst ; 112(5): 673-8, 1987 May.
Article in English | MEDLINE | ID: mdl-3605629

Subject(s)
Pesticide Residues/analysis , Food Analysis , Quality Control , Reference Values
3.
The effect of aflatoxins on mammalian acid deoxyribonucleases.
Lötter, L H; Schabort, J C.
Int J Biochem ; 15(6): 817-25, 1983.
Article in English | MEDLINE | ID: mdl-6407882

ABSTRACT

1. Difference spectroscopy studies indicated that tetrahydrodeoxyaflatoxin B1 and aflatoxicol bind slightly to DNA, whereas aflatoxins B2a, G2a, G2 and aflatoxicol bind to bovine and porcine spleen DNAse II but aflatoxins B1, B2, G1 and tetrahydrodeoxyaflatoxin did not. 2. Kinetic studies showed that aflatoxins B1, G1 and B2 activated bovine and porcine spleen DNAse II while aflatoxins B2a, G2a and G2 had an inhibiting effect. 3. Dissociation constants for the enzyme: substrate-aflatoxin complexes (KAS) as well as the inhibition constants (Ki) were obtained from kinetic studies.


Subject(s)
Aflatoxins/pharmacology , Endodeoxyribonucleases/metabolism , Aflatoxin B1 , Animals , Carcinogens , Cattle , Endodeoxyribonucleases/antagonists & inhibitors , Enzyme Activation/drug effects , Hydrogen-Ion Concentration , Spleen/enzymology , Swine
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