1.
Org Lett
; 17(3): 688-91, 2015 Feb 06.
Article
in English
| MEDLINE
| ID: mdl-25621822
ABSTRACT
A combination of an amino acid derived chiral phosphine catalyst and methyl acrylate efficiently catalyzed the direct Mannich reaction of cyclic ß-ketoesters and N-Boc-aldimines. The dual-reagent catalysis was presumed to function through the formation of a zwitterion, which catalyzed the reaction with excellent stereocontrol via a hydrogen-bonding assisted chiral ion-pair pathway.