ABSTRACT
The reaction of either Digitoxin or Digoxin with cyanoacetic acid hydrazide gave the hydrazone derivatives 3a and 3b respectively. The reactivity of the latter products towards chemical reagents was studied to give heterocyclic derivatives with potential biological activities.
Subject(s)
Digitoxin/chemistry , Digoxin/chemistry , Hydrazines/chemistry , Coumarins/chemical synthesis , Indicators and Reagents , Magnetic Resonance Spectroscopy , Pyridines/chemical synthesis , Thiazoles/chemical synthesis , Thiophenes/chemical synthesisABSTRACT
The reaction of epi-androsterone with cyanoacetyl hydrazine (2) gave the hydrazone derivative 3. The reactivity of 3 towards chemical reagents was studied to give pyridine, thiazole and thiophene derivatives.
Subject(s)
Androsterone/analogs & derivatives , Androsterone/chemical synthesis , Antineoplastic Agents/chemical synthesis , Pyridines/chemical synthesis , Thiazoles/chemical synthesis , Thiophenes/chemical synthesis , Androsterone/pharmacology , Animals , Antineoplastic Agents/pharmacology , Pyridines/pharmacology , Thiazoles/pharmacology , Thiophenes/pharmacology , Tumor Cells, CulturedABSTRACT
A correlation between testosterone (T) and dihydrotestosterone (DHT) exists in seminal plasma. These androgens play a role in sperm maturation. The T/DHT ratio is different from one person to the other, due to the heterogenicity of seminal plasma which stems for the most part from the male accessory sex glands, the prostate and seminal vesicles, and also from the 'epididymo-testicular unit'. This ratio is useful in identifying the person's semen. Consequently, the steroid values from assailant semen or accused persons and semen on the victim's clothes are of cardinal importance in matching. The results reported include data on the validation of this technique as a tool for semen identification. Coital and masturbated semen were correlated, and consecutive coital semen were also analysed. It may be concluded that the T/DHT value is specific for each person.
