ABSTRACT
The tolerance of exercise and its effects on quality of life in myasthenia gravis are not currently backed up by strong evidence. The aim of this study was to determine whether exercise as an adjunct therapy is well tolerated and can improve health-related quality of life (HRQoL) in stabilized, generalized autoimmune myasthenia gravis (gMG). We conducted a parallel-group, multi-center prospective RCT using computer-generated block randomization. Adults with stabilized, gMG, and no contra-indication to exercise, were eligible. Participants received usual care alone or usual care and exercise. The exercise intervention consisted of 3-weekly 40 min sessions of an unsupervised, moderate-intensity home rowing program over 3 months. The primary endpoint was the change in HRQoL from randomization to post-intervention. Assessor-blinded secondary endpoints were exercise tolerance and effects on clinical, psychological and immunological status. Of 138 patients screened between October 2014 and July 2017, 45 were randomly assigned to exercise (nâ¯=â¯23) or usual care (nâ¯=â¯20). Although exercise was well tolerated, the intention-to-treat analysis revealed no evidence of improved HRQoL compared to usual care (MGQOL-15-F; mean adjusted between-groups difference of -0.8 points, 95%CI -5.4 to 3.7). Two patients hospitalized for MG exacerbation were from the usual care group.
Subject(s)
Exercise Therapy/methods , Myasthenia Gravis/therapy , Adult , Aged , Exercise , Exercise Tolerance , Female , Humans , Male , Middle Aged , Prospective Studies , Quality of LifeABSTRACT
Ovarian cancer is the fifth most common cancer in women in France with 4714 new cases in 2017. More than 70% of patients whose disease is initially locally advanced will present locoregional or distant recurrence. Therapeutic options in this situation are not consensual. They are based on chemotherapy possibly associated with an iterative cytoreductive surgery when it is bearable by the patient. The place of radiotherapy in the management of the disease is hidden in the vast majority of national or international standards. We conducted a general review of the literature to clarify the role of irradiation in the global management of ovarian cancers, particularly in recurrence.
Subject(s)
Neoplasm Recurrence, Local/radiotherapy , Ovarian Neoplasms/radiotherapy , Antineoplastic Agents/therapeutic use , Female , Humans , Neoplasm Recurrence, Local/classification , Ovarian Neoplasms/classification , Palliative Care/methods , Radiosurgery/methods , Radiotherapy, Adjuvant , Radiotherapy, Conformal/methodsABSTRACT
BACKGROUND: Little is known on the phenomenology and potential prognosis factors of bipolar episodes in adolescents. In particular, very few studies examine this issue on inpatients in the European context of free access to care. OBJECTIVE: To assess the follow-up in adulthood of acute manic and mixed episodes in hospitalized adolescents and the predictive value of psychological testing. METHODS: 80 subjects, aged 12 to 20 years, consecutively hospitalized for a manic or mixed episode between 1994 and 2003, were contacted in 2005-2006 for a follow-up assessment. 5 patients refused, 20 were lost, 55 patients were assessed by direct and complete interview (67%) or by phone and treating psychiatrist (33%). RESULTS: At index episode, the sample was characterized by severe impairment, high rates of psychotic features (N = 50, 62,5%), a long duration of stay (mean = 80,4 days), and an overall good improvement at discharge from hospital (86% very much or much improved). Half had a psychological testing before discharge. At follow-up (mean average 5 years), 35 patients still had a diagnosis of bipolar disorder. Eight changed life-time diagnosis for schizoaffective disorder and 11 for schizophrenia. Mortality and morbidity were severe with one subject who died from cardiac failure, and 91% of patients who had at least one relapse. Patients without relapse (N = 5) and patients showing a good social functioning (N = 19) remained with a diagnosis of bipolar disorder. Using a clinical global impression method, psychological testing (blind with follow-up status) was significantly correlated with transition to schizophrenia spectrum disorder. CONCLUSION: Contrarily to what is seen in less severe sample of bipolar disorder, changes in life time diagnosis can occur during follow-up after a manic or mixed episode in adolescence, as many patients are in the schizophrenia spectrum in adulthood.
