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1.
Pharmaceuticals (Basel) ; 16(11)2023 Nov 14.
Article in English | MEDLINE | ID: mdl-38004468

ABSTRACT

Entecavir (ETV) is a drug used as a first-line treatment for chronic hepatitis B (CHB) virus infection because it is a guanosine nucleoside analogue with activity against the hepatitis B virus polymerase. The ETV dosage can range from 0.5 mg to 1 mg once a day and the most common side effects include headache, insomnia, fatigue, dizziness, somnolence, vomiting, diarrhea, nausea, dyspepsia, and increased liver enzyme levels. In addition to its conventional use, ETV acts as an inhibitor of lysine-specific demethylase 5B (KDM5B), an enzyme that is overexpressed in breast, lung, skin, liver, and prostate tumors and is involved in the hormonal response, stem cell regeneration, genomic stability, cell proliferation, and differentiation. The KDM5B enzyme acts as a transcriptional repressor in tumor suppressor genes, silencing them, and its overexpression leads to drug resistance in certain tumor types. Furthermore, the literature suggests that KDM5B activates the PI3K/AKT signaling pathway, while reducing KDM5B expression decreases AKT signaling, resulting in decreased tumor cell proliferation. In silico studies have demonstrated that ETV can inhibit tumor cell proliferation and induce apoptosis by reducing KDM5B expression. ETV also appears to inhibit PARP-1, has a high genetic barrier, reducing the chance of resistance development, and can also prevent the reactivation of the hepatitis B virus in cancer patients, which have proven to be significant advantages regarding its use as a repurposed drug in oncology. Therefore, ETV holds promise beyond its original therapeutic indication.

2.
Int J Mol Sci ; 24(4)2023 Feb 19.
Article in English | MEDLINE | ID: mdl-36835564

ABSTRACT

Worldwide, prostate cancer (PC) is the second most frequent cancer among men and the fifth leading cause of death; moreover, standard treatments for PC have several issues, such as side effects and mechanisms of resistance. Thus, it is urgent to find drugs that can fill these gaps, and instead of developing new molecules requiring high financial and time investments, it would be useful to select non-cancer approved drugs that have mechanisms of action that could help in PC treatment, a process known as repurposing drugs. In this review article, drugs that have potential pharmacological efficacy are compiled to be repurposed for PC treatment. Thus, these drugs will be presented in the form of pharmacotherapeutic groups, such as antidyslipidemic drugs, antidiabetic drugs, antiparasitic drugs, antiarrhythmic drugs, anti-inflammatory drugs, antibacterial drugs, antiviral drugs, antidepressant drugs, antihypertensive drugs, antifungal drugs, immunosuppressant drugs, antipsychotic drugs, antiepileptic and anticonvulsant drugs, bisphosphonates and drugs for alcoholism, among others, and we will discuss their mechanisms of action in PC treatment.


Subject(s)
Drug Repositioning , Prostatic Neoplasms , Male , Humans , Antiviral Agents/therapeutic use , Anticonvulsants/therapeutic use , Anti-Bacterial Agents/therapeutic use , Prostatic Neoplasms/drug therapy
3.
REME rev. min. enferm ; 27: 1503, jan.-2023. Tab.
Article in English, Portuguese | LILACS, BDENF - Nursing | ID: biblio-1527058

ABSTRACT

Objetivo: investigar a associação entre força de preensão manual e características sociodemográficas e clínicas de idosos condutores de veículos automotores. Método: estudo transversal, realizado em clínicas de medicina de tráfego na cidade de Curitiba/Paraná, com 421 idosos (≥ 60 anos). Realizou-se análise estatística pelo modelo de Regressão Logística e Teste de Wald, considerando intervalo de confiança de 95% e valores de p <0,05 como significativos. Resultados: oitenta e quatro (20%) idosos apresentaram força de preensão manual reduzida. A força de preensão manual reduzida foi associada à faixa etária (p=0,001) e à hospitalização no último ano (p=0,002). Conclusão: houve associação significativa entre a força de preensão manual de idosos motoristas e as variáveis idade e hospitalização no último ano. Dessa forma, torna-se essencial a inclusão de avaliações específicas, centradas nas variáveis sociodemográficas e clínicas próprias da pessoa idosa, durante o exame de aptidão para dirigir veículos automotores.(AU)


Objective: to investigate the association between handgrip strength and sociodemographic and clinical characteristics of elderly automobile drivers. Method: cross-sectional study, carried out in traffic medicine clinics in the city of Curitiba/Paraná, with 421 elderly people (≥ 60 years old). Statistical analysis was performed using the Logistic Regression model and the Wald Test, considering a 95% confidence interval and p values <0.05 as significant. Results: eighty-four (20%) seniors had reduced handgrip strength. Reduced handgrip strength was associated with age group (p=0.001) and hospitalization in the last year (p=0.002). Conclusion: there was a significant association between the handgrip strength of elderly drivers and the variables age and hospitalization in the last year. Thus, it is essential to include specific assessments, centered on sociodemographic and clinical variables specific to the elderly person, during the aptitude test to drive automobiles.(AU)


Objetivo: investigar la asociación entre la fuerza de prensión de la mano y las características sociodemográficas y clínicas de los ancianos conductores de vehículos automotores. Método: estudio transversal, realizado en clínicas de medicina de tránsito de la ciudad de Curitiba/Paraná, con 421 ancianos (≥ 60 años). El análisis estadístico fue realizado por el modelo de Regresión Logística y Test de Wald, considerando intervalo de confianza de 95% y valores de p <0,05 como significativos. Resultados: 84 (20%) sujetos ancianos presentaron reducción de la fuerza de prensión de la mano. La reducción de la fuerza de prensión de la mano se asoció al grupo de edad (p=0,001) y a la hospitalización en el último año (p=0,002). Conclusión: hubo una asociación significativa entre la fuerza de prensión de la mano de los conductores ancianos y las variables edad y hospitalización en el último año. Así pues, es esencial incluir evaluaciones específicas, centradas en las variables sociodemográficas y clínicas de los ancianos, durante el examen de aptitud para conducir vehículos automotores.(AU)


Subject(s)
Humans , Aged , Automobile Driving , Automobiles , Health of the Elderly , Hand Strength , Sociodemographic Factors , Socioeconomic Factors , Automobile Driver Examination , Logistic Models
4.
Rev. bras. enferm ; 76(1): e20210729, 2023. tab
Article in English | LILACS-Express | LILACS, BDENF - Nursing | ID: biblio-1407476

ABSTRACT

ABSTRACT Objective: to analyze handgrip strength as a predictor of the inability to drive in older adults. Method: a cross-sectional study conducted in traffic clinics with 421 older adults in Curitiba-Paraná from January 2015 to December 2018. A sociodemographic and clinical questionnaire, handgrip strength test, and queries from the National Registry of Qualified Drivers form were applied. Results: Reduced handgrip strength was not a predictor of inaptitude for vehicular driving (p=0.649). The predictors of inaptitude were: low education (p=0.011), incomplete elementary education (p=0.027), and cognition (p=0.020). Conclusion: reduced handgrip strength was not shown to predict for loss of driving skills in older adults. Low education level and reduced cognition level are conditions that were shown to be predictors for loss of vehicular driving license.


RESUMEN Objetivo: analizar la fuerza de prensión manual como factor predictivo de inaptitud para la conducción vehicular de adultos mayores. Método: se trata de un estudio transversal llevado a cabo en clínicas de tránsito de Curitiba, Paraná, entre 421 adultos mayores, de enero de 2015 a diciembre de 2018. Se aplicaron los cuestionarios sociodemográfico y clínico, la prueba de fuerza de prensión manual y se consultó el formulario del Registro Nacional de Conductores Habilitados. Resultados: la fuerza de prensión manual reducida no fue un factor predictivo de la incapacidad para conducir (p=0,649). Los predictores de inaptitud fueron: baja educación (p=0,011), estudios primarios incompletos (p=0,027) y cognición (p=0,020). Conclusión: la fuerza de prensión manual reducida no demostró ser predictora de la pérdida de habilidades de conducción vehicular en adultos mayores. El nivel de escolaridad bajo y el nivel cognitivo reducido despuntaron como predictores de la pérdida de habilitación en la conducción vehicular.


RESUMO Objetivo: analisar a força de preensão manual como preditora de inaptidão para condução veicular de idosos. Método: estudo transversal realizado em clínicas de trânsito com 421 idosos em Curitiba-Paraná de janeiro de 2015 a dezembro de 2018. Aplicaram-se questionários sociodemográfico e clínico, teste de força preensão manual e consultas ao formulário de Registro Nacional de Condutores Habilitados. Resultados: A força de preensão manual reduzida não se mostrou preditora de inaptidão para a direção veicular (p=0,649). Os preditores de inaptidão foram: baixa escolaridade (p=0,011), ensino primário incompleto (p=0,027) e cognição (p=0,020). Conclusão: a força de preensão manual reduzida não se mostrou preditora para perda da habilitação na condução veicular de idosos. O baixo nível de escolaridade, o nível de cognição reduzida, são condições que se mostraram preditoras para a perda da habilitação na condução veicular.

5.
Rev Bras Enferm ; 76(1): e20210729, 2022.
Article in English, Portuguese | MEDLINE | ID: mdl-36449971

ABSTRACT

OBJECTIVE: to analyze handgrip strength as a predictor of the inability to drive in older adults. METHOD: a cross-sectional study conducted in traffic clinics with 421 older adults in Curitiba-Paraná from January 2015 to December 2018. A sociodemographic and clinical questionnaire, handgrip strength test, and queries from the National Registry of Qualified Drivers form were applied. RESULTS: Reduced handgrip strength was not a predictor of inaptitude for vehicular driving (p=0.649). The predictors of inaptitude were: low education (p=0.011), incomplete elementary education (p=0.027), and cognition (p=0.020). CONCLUSION: reduced handgrip strength was not shown to predict for loss of driving skills in older adults. Low education level and reduced cognition level are conditions that were shown to be predictors for loss of vehicular driving license.


Subject(s)
Aptitude , Automobile Driving , Humans , Aged , Hand Strength , Cross-Sectional Studies , Educational Status
6.
SAGE Open Nurs ; 8: 23779608221094547, 2022.
Article in English | MEDLINE | ID: mdl-35493546

ABSTRACT

Introduction: Lockdowns due to the COVID-19 pandemic radically changed nursing education. Along with social isolation, the transition to distance education affected the well-being of students in several countries, particularly Portugal and Spain. Objectives: To identify which variables are predictors of psychological well-being for Portuguese and Spanish nursing students during mandatory lockdowns. Methods: A multicenter, cross-sectional, descriptive, correlational study involving a sample of 1075 students (944 women, mean age 22.46 + /-4.95 years). Data were collected from an online questionnaire which applied the following scales: Perceived Stress Scale (α = .820); Brief COPE-14 Subscales (α = .430 < 0.930); Well-being Manifestations Measure Scale (α = .940); Herth Hope Index (α = .850). A multiple regression model was created to predict the psychological well-being of nursing students. Results: The following predictor variables were identified in the model of the psychological well-being of students during the COVID-19 pandemic: perceived stress (ß = .405; p ≤ .001); hope (ß = .404; p ≤ .001); and the mechanisms of active coping (ß = .405; p ≤ .001), planning (ß = .097; p ≤ .001), and positive reinterpretation (ß = .053; p = .12). These five variables predicted 62.0% of the nursing students' psychological well-being (R 2 = .620; F = 350.82; p ≤ .001). Conclusion: Promoting students' mental health is essential, especially in periods of great adversity, such as a pandemic. Our results lead the way for the design and validation of an intervention program that addresses the five variables identified as predictors of students' psychological well-being.

7.
Int J Ment Health Nurs ; 31(4): 920-932, 2022 Aug.
Article in English | MEDLINE | ID: mdl-35385603

ABSTRACT

Worldwide, the COVID-19 pandemic has had a disruptive effect on daily routines, especially for university students. This study aimed to compare pre-pandemic domains of students' mental health during the pandemic lockdown. One cross-sectional study was conducted in two waves with academic students from 20 Portuguese universities, in March 2020 before the COVID-19 pandemic (n = 3579) and 2 months after the first lockdown in May 2020 (n = 1228). The Positive Mental Health Questionnaire (PMHQ), the Mental Health Knowledge Questionnaire, the Mental Health-promoting knowledge, and the Psychological Vulnerability Scale were used. Statistical analyses were performed by bivariate associations and multiple linear regression models. Students were mostly women (79%), with an average age of 23.2 years (SD = 6.6), displaced from their family environment (43%), out-of-home (43%), and scholarship holders (37%). Higher scores found in the PVS were associated with decreased PMHQ in both moments (P < 0.01). These cross-sectional studies showed a slight variation in the mental health variables studied in the period before and during the COVID-19 outbreak. Being a woman, younger, out-of-home, and having a scholarship (P < 0.01) seem to increase susceptibility to mental health variation before and during the pandemic. Universities should develop strategies that promote students' mental health.


Subject(s)
COVID-19 , Adult , COVID-19/epidemiology , COVID-19/prevention & control , Communicable Disease Control , Cross-Sectional Studies , Female , Humans , Male , Mental Health , Pandemics , Portugal/epidemiology , Students/psychology , Universities , Young Adult
8.
Referência ; serV(8,supl.1): e20211, dez. 2021. tab
Article in Portuguese | LILACS-Express | BDENF - Nursing | ID: biblio-1365326

ABSTRACT

Resumo Enquadramento: A crise pandémica da COVID-19 acarretou mudanças na vida académica dos estudantes do ensino superior, o que poderá afetar o seu bem-estar psicológico. Objetivo: Analisar a relação entre estratégias de coping utilizadas e o bem-estar psicológico em estudantes de enfermagem durante a quarentena pela COVID-19. Metodologia: Estudo transversal, descritivo-correlacional, utilizando uma amostra de 136 estudantes. Colheita de dados online, com recurso à Escala de Medida de Manifestação de Bem-estar Psicológico e à Brief COPE. Resultados: Os estudantes dos últimos anos de curso utilizam mais frequentemente a estratégia de coping suporte instrumental (p = 0,015) e emocional (p = 0,009), apresentam ainda, maiores níveis de bem-estar psicológico (p = 0,012). As alterações no rendimento familiar estão associadas ao bem-estar psicológico (p = 0,024), assim como as estratégias de coping religião (r = 0,36; p ≤ 0,01), reinterpretação positiva (r = 0,47; p ≤ 0,01) e humor (r = 0,37; p ≤ 0,01). Conclusão: As estratégias de coping adotadas pelos estudantes parecem estar relacionadas com o bem-estar psicológico durante a quarentena.


Abstract Background: The COVID-19 pandemic crisis has brought about changes in the lives of higher education students that may influence their psychological well-being. Objective: To analyze the association between nursing students' coping strategies and their psychological well-being during the COVID-19 quarantine. Methodology: Cross-sectional, descriptive-correlational study using a convenience sample of 136 students. Data were collected online using the Portuguese version of the Échelle de Mesure des Manifestations du Bien-être Psychologique and the Brief COPE. Results: Students in the last years of their undergraduate studies used the instrumental support (p = 0.015) and emotional support (p = 0.009) coping strategies more often and had higher levels of psychological well-being (p = 0.012). Psychological well-being is associated with household income changes (p = 0.024), as well as with religion (r = 0.36; p ≤ 0.01), positive reframing (r = 0.47; p ≤ 0.01), and humor (r = 0.37; p ≤ 0.01) coping strategies. Conclusion: Students' coping strategies seem to be associated with their psychological well-being during the COVID-19 quarantine.


Resumen Marco contextual: La crisis provocada por la pandemia de la COVID-19 produjo cambios en la vida académica de los estudiantes de educación superior, que pueden afectar su bienestar psicológico. Objetivo: Analizar la relación entre las estrategias de afrontamiento utilizadas y el bienestar psicológico en estudiantes de enfermería durante la cuarentena por la COVID-19. Metodología: Estudio transversal, descriptivo-correlacional, con una muestra de 136 estudiantes. La recopilación de datos se realizó en línea mediante la Escala de Medición de la Manifestación del Bienestar Psicológico y el Brief COPE. Resultados: Los estudiantes de los últimos cursos utilizan con más frecuencia la estrategia de afrontamiento apoyo instrumental (p = 0,015) y emocional (p = 0,009), y también tienen mayores niveles de bienestar psicológico (p = 0,012). Los cambios en los ingresos familiares se asocian con el bienestar psicológico (p = 0,024), así como con las estrategias de afrontamiento religión (r = 0,36; p ≤ 0,01), reinterpretación positiva (r = 0,47; p ≤ 0,01) y estado de ánimo (r = 0,37; p ≤ 0,01). Conclusión: Las estrategias de afrontamiento adoptadas por los estudiantes parecen estar relacionadas con el bienestar psicológico durante la cuarentena.

9.
Av. enferm ; 39(1): 84-92, 01 de enero de 2021.
Article in Spanish | COLNAL, BDENF - Nursing, LILACS | ID: biblio-1151186

ABSTRACT

Objetivo: analizar la asociación entre la velocidad de la marcha y la cognición de adultos mayores que se encuentran en asistencia ambulatoria geriátrica y gerontológica. Materiales y método: estudio cuantitativo transversal realizado con 407 adultos mayores (≥ 60 años) atendidos en el Centro Ambulatorio de Geriatría y Gerontología del municipio de São José dos Pinhais, Paraná (Brasil). La condición de fragilidad física se evaluó utilizando el fenotipo de fragilidad y el cribado cognitivo mediante el Mini-Mental State Examination y el test de fluencia verbal semántica. El análisis univariado se realizó mediante una prueba de chi-cuadrado con nivel de significación estadístico de p ≤ 0,05. Resultados: del total de participantes, se observaron 226 (55,5 %) adultos mayores prefrágiles, 238 (58,5 %) reportaron deterioro cogntivo, 90 (22 %) de la fluidez verbal semántica y 205 (50,4 %) presentaron velocidad de la marcha reducida, variable que registró una asociación significativa con el deterioro cognitivo (p = 0,003) y las alteraciones de la fluencia verbal semántica (p < 0,001).Conclusiones: los resultados señalan la necesidad de implementar la evaluación de la velocidad de la marcha en adultos mayores como parte de la práctica clínica de geriatría y gerontología. Este componente revela un posible deterioro cognitivo y permite la realización de acciones que puedan perfeccionar el manejo de los cuidados ante la fragilidad física en adultos mayores.


Objetivo: analisar a associação entre a velocidade da marcha e a cognição de idosos em assistência ambulatorial de geriatria e gerontologia. Materiais e método: estudo quantitativo transversal, realizado com 407 idosos (≥ 60 anos), atendidos no Ambulatório de Geriatria e Geron-tologia, do município de São José dos Pinhais, Paraná, Brasil. A condição de fragilidade física foi avaliada mediante o fenótipo de fragilidade e o rastreio cognitivo pelo Mini-Exame do Estado Mental e Teste de Fluência Verbal Semântica. A análise univariada foi realizada por teste de quiquadrado com nível de significância estatístico de p ≤ 0,05. Resultados:do total de participantes, foram observados 226 (55,5 %) idosos pré-frágeis, 238 (58,5 %) apresentaram declínio cognitivo, 90 (22 %) comprometimento na fluência verbal semântica e 205 (50,4 %) velocidade da marcha reduzida, variável que registrou associação significativa com o comprometimento cognitivo (p = 0,003) e alterações da fluência verbal semântica (p < 0,001). Conclusões: os resultados apontam para a necessidade de implementar na prática clínica de geriatria e gerontologia a avaliação da velocidade da marcha em idosos. Esse componente revela possibilidades de comprometimento cognitivo e faculta ações que possam aprimorar a gestão de cuidados diante da fragilidade física em idosos


Objective: To study the association between gait speed and cognition in elderly patients undergoing geriatric and gerontological outpatient treatment. Materials and method:Quantitative and cross-sectional study with 407 elderly patients (≥60 years) treated at the Geriatrics and Gerontology Outpatient Clinic in the town of São José dos Pinhais, Paraná (Brazil). Physical frailty condi-tion was assessed using the frailty phenotype and the cognitive assessment by means of the Mini Mental State Examination and the Semantic Verbal Fluency Test. The univariate analysis was performed using a chisquare test with a level of statistical significance of p ≤ 0.05. Results: Out of the total participants, we observed that 226 (55.5%) elderly patients were pre-frail, 238 (58.5%) had cognitive impairments, 90 (22%) showed impaired semantic verbal fluency, and 205 (50.4%) decreased gait speed. This last variable showed a significant association with cognitive decline (p = 0.003) and changes in semantic verbal fluency (p < 0.001). Conclusions: Our results indicate the need of implementing gait speed assessment in elderly patients in the geriatrics and gerontology clinical practice. This component reveals a possible cognitive deterioration and enables us to develop actions that may improve care management in the face of physical frailty in elderly individuals.


Subject(s)
Humans , Aged , Aged, 80 and over , Aged , Frail Elderly , Cognitive Dysfunction , Gait , Speech Disorders
10.
Esc. Anna Nery Rev. Enferm ; 25(spe): e20200548, 2021. tab
Article in Portuguese | LILACS, BDENF - Nursing | ID: biblio-1292381

ABSTRACT

Objetivo: analisar as relações entre a esperança e o bem-estar psicológico de estudantes de enfermagem portugueses durante a crise pandêmica pela COVID-19. Método: estudo descritivo-correlacional, com recurso a questionário online para coleta de dados. Participaram 705 estudantes de enfermagem com idade média de 21,74 anos (DP=4,44). Os instrumentos de coleta de dados utilizados foram a Escala de Esperança de Herth (HHI-PT) e a Escala de Medida de Manifestação de Bem-Estar Psicológico (EMMBEP). Foi utilizada a estatística descritiva e inferencial. Resultados: na HHI-PT, o domínio afectivo-comportamental obteve a pontuação média mais alta, 3,30 (DP=0,45); no EMMBEP, foi o domínio sociabilidade, 3,64 (DP=0,77). Havia correlações moderadas a fortes (0,383

Aim: to analyze the relationship between hope and the psychological well-being of Portuguese nursing students during the COVID-19 pandemic crisis. Method: this is a descriptive-correlational study using an online questionnaire for data collection. 705 nursing students participated, with a mean age of 21.74 years (SD=4.44). The data collection instruments used were the Herth Hope Index (HHI-PT) and the Well-Being Manifestations Measure Scale (WBMMS). Descriptive and inferential statistics were used. Results: in the HHI-PT, the affective-behavioral domain had the highest mean score (3.30; SD=0.45), while in the WBMMS, it was the sociability domain, 3.64 (SD=0.77). There were moderate to strong correlations (0.383

Objetivo: analizar la relación entre la esperanza y el bienestar psicológico de los estudiantes portugueses de enfermería durante la crisis pandémica por COVID-19. Método: estudio descriptivo-correlacional mediante cuestionario online para la recogida de datos. Participaron 705 estudiantes de enfermería, con una edad promedio de 21,74 años (DE=4,44). Los instrumentos de recolección de datos utilizados fueron la Escala de Esperanza de Herth (HHI-PT) y la Escala de Medida de Manifestación de Bienestar Psicológico (EMMBEP). Se utilizó estadística descriptiva e inferencial. Resultados: en HHI-PT, fue el dominio afectivoconductual el que obtuvo la puntuación promedio más alta, 3.30 (DE=0.45), en EMMBEP, fue el dominio de sociabilidad, 3.64 (DE=0.77). Hubo correlaciones de moderadas a fuertes (0.383

Subject(s)
Humans , Male , Female , Adult , Middle Aged , Students, Nursing/psychology , Adaptation, Psychological , Mental Health/statistics & numerical data , Pandemics , Hope , COVID-19/psychology , Personal Satisfaction , Portugal/ethnology , Students, Nursing/statistics & numerical data , Family/psychology , Cross-Sectional Studies , Education, Distance , Physical Distancing
11.
Texto & contexto enferm ; 30: e20200549, 2021. tab
Article in English | LILACS, BDENF - Nursing | ID: biblio-1341724

ABSTRACT

ABSTRACT Objective: to clinically validate the defining characteristics of the "Caregiver Role Strain" Nursing diagnosis for caregivers of people in a palliative care situation. Method: a cross-sectional, quantitative, descriptive and analytical study. It was developed based on Fehring's Clinical Validation Model and on the diagnostic accuracy measures (sensitivity, specificity, predictive values and Receiver Operating Characteristic curve). The data collection instrument used was a form, applied in 2017 by two nurses to a sample of 111 caregivers of people in a palliative care situation, in Portugal. The caregivers were divided into two groups (with and without the diagnosis), being identified by the simultaneity of three criteria, namely: Zarit Burden Interview values greater than 56; agreement of two nurses about the diagnosis; and caregiver's perception of the presence of signs and symptoms. The defining characteristics were classified as major, secondary and irrelevant, according to the models used. Results: the prevalence of diagnosis was 42.3%. Of the 29 characteristics subjected to the validation process, 9 were considered major, 13 secondary and 7 irrelevant. Ineffective coping, depressive mood, frustration, worsening of previous diseases, stress and fatigue were the characteristics which proved to be more associated with the diagnosis in both analyses. The overall score of the diagnosis was 0.68. Conclusion: the study results contribute to the improvement of the diagnosis, making it more accurate. In addition, they enable better clinical decision in Nursing, allowing nurses to make a diagnostic judgment supported by scientific evidence.


RESUMEN Objetivo: validar clínicamente las características definitorias del diagnóstico de Enfermería "Cansancio del rol de Cuidador de personas en situación de cuidados paliativos". Método: estudio descriptivo y analítico de tipo transversal y naturaleza cuantitativa. Se desarrolló sobre la base del Modelo de Validación Clínica de Fehring y de las medidas de exactitud diagnóstica (sensibilidad, especificidad, valores predictivos y curva Receiver Operating Characteristic). El instrumento para la recolección de dados utilizado fue un formulario, aplicado en el año 2017 por dos enfermeras a una muestra de 111 cuidadores de personas en situación de cuidados paliativos en Portugal. Se dividió a los cuidadores en dos grupos (con y sin el diagnóstico), identificados por la simultaneidad de tres criterios: valores de la escala de Zarit de sobrecarga del cuidador superiores a 56; acuerdo de dos enfermeras acerca del diagnóstico; y percepción del cuidador con respecto a la presencia de señales y síntomas. Las características definitorias se clasificaron como principales, secundarias e irrelevantes, mediante los modelos utilizados. Resultados: la prevalencia del diagnóstico fue del 42,3%. De las 29 características sujetas al proceso de validación, 9 fueron consideradas como principales, 13 como secundarias y 7 como irrelevantes. Afrontamiento poco eficaz, estado de ánimo depresivo, frustración, deterioro de enfermedades previas, estrés y fatiga fueron las características que demostraron mayor asociación con el diagnóstico en ambos análisis. El score global del diagnóstico fue 0,68. Conclusión: los resultados del estudio son útiles para mejorar el diagnóstico, aumentando su exactitud. También hacen posible tomar mejores decisiones clínicas en Enfermería, permitiendo así que los enfermeros tomen determinaciones diagnósticas sobre la base de evidencias científicas.


RESUMO Objetivo: validar clinicamente as características definidoras do diagnóstico de enfermagem "Tensão do Papel de Cuidador da pessoa em situação paliativa". Método: estudo do tipo transversal, de natureza quantitativa, descritivo e analítico. Desenrolou-se ancorado no Modelo de Validação Clínica de Fehring e nas medidas de acurácia diagnóstica (sensibilidade, especificidade, valores preditivos e curva Receiver Operating Characteristic). O instrumento de coleta de dados utilizado foi um formulário, aplicado por duas enfermeiras, a uma amostra de 111 cuidadores de pessoas em situação paliativa, em Portugal, em 2017. Os cuidadores foram divididos em dois grupos (com e sem diagnóstico), sendo identificados pela simultaneidade de três critérios: valores da escala de sobrecarga do cuidador de Zarit superiores a 56; concordância de duas enfermeiras acerca do diagnóstico; e a percepção do cuidador quanto à presença de sinais e sintomas. Classificaram-se as caraterísticas definidoras em principais, secundárias e irrelevantes, mediante os modelos utilizados. Resultados: a prevalência do diagnóstico foi de 42,3%. Das 29 características sujeitas ao processo de validação, 9 foram consideradas principais, 13 secundárias e 7 irrelevantes. O enfrentamento ineficaz, o humor depressivo, a frustração, o agravamento de doenças prévias, o estresse e a fadiga foram as características que se revelaram mais associadas ao diagnóstico em ambas as análises. O score global do diagnóstico foi de 0,68. Conclusão: os resultados do estudo contribuem para o aprimoramento do diagnóstico, tornando-o mais acurado. Ademais, possibilitam melhor decisão clínica em enfermagem, permitindo aos enfermeiros um juízo diagnóstico apoiado em evidências científicas.


Subject(s)
Humans , Palliative Care , Stress, Psychological , Nursing Diagnosis , Caregivers , Validation Study
12.
Acta Paul. Enferm. (Online) ; 34: eAPE00541, 2021. tab
Article in Portuguese | BDENF - Nursing, LILACS | ID: biblio-1152661

ABSTRACT

Resumo Objetivo: Investigar a associação entre cognição, velocidade da marcha e resultado final da habilitação veicular de idosos candidatos à Carteira Nacional de Habilitação. Métodos: Estudo quantitativo de corte transversal desenvolvido em 12 clínicas de trânsito de Curitiba/Paraná/Brasil. A amostra do tipo probabilística foi constituída por 421 idosos (≥ 60 anos). Para a coleta de dados foram aplicados o Mini-Exame do Estado Mental (MEEM), teste de velocidade da marcha e realizadas consultas ao formulário Registro Nacional de Condutores Habilitados. A relação entre as variáveis foi identificada por meio do teste de regressão linear múltipla, método stepwise, utilizando-se o programa estatístico R versão 3.4.0. Resultados: Observou-se que, ao aumentar o escore no MEEM em uma unidade a chance do idoso ser considerado inapto temporariamente para dirigir diminui em 54,96% (95%; IC 28,47% - 92,69%; p<0,0001), e ao aumentar uma unidade no escore do MEEM houve um aumento na velocidade da marcha (VM) de 0,0091 (95%; IC 0,0005 - 0,0174; p=0,0366). Conclusão: O elevado escore no MEEM diminuiu a probabilidade do idoso ser considerado inapto temporariamente para dirigir veículos automotores e houve uma tendência de aumento da VM com o aumento dos escores do MEEM. A VM é um importante indicador a ser avaliado em idosos motoristas, logo, é um tópico a ser incluído nas avaliações das clínicas de trânsito, assim como o rastreamento cognitivo, fundamental para avaliar um conjunto de atividades mentais necessárias à direção veicular segura.


Resumen Objetivo: Investigar la relación entre cognición, velocidad de la marcha y obtención del permiso de conducir en adultos mayores que tramitan la licencia de conducir. Métodos: Estudio cuantitativo de corte transversal llevado a cabo en 12 centros médicos de evaluación de tránsito de Curitiba, estado de Paraná, Brasil. La muestra probabilística fue formada por 421 adultos mayores (≥ 60 años). Para la recolección de datos se aplicó el Mini Examen del Estado Mental (MEEM), la prueba de velocidad de la marcha y se realizaron consultas al formulario del Registro Nacional de Conductores Habilitados. La relación entre las variables fue identificada mediante la prueba de regresión lineal múltiple, método stepwise, con el programa de estadística R versión 3.4.0. Resultados: Se observó que, al aumentar la puntuación del MEEM una unidad, la probabilidad de que el adulto mayor sea considerado no apto temporalmente para conducir se redujo un 54,96 % (95 %; IC 28,47 % - 92,69 %; p<0,0001), y al aumentar una unidad la puntuación del MEEM, hubo un aumento en la velocidad de la marcha (VM) de 0,0091 (95 %; IC 0,0005 - 0,0174; p=0,0366). Conclusión: La puntuación del MEEM elevada redujo la probabilidad de que el adulto mayor sea considerado no apto temporalmente para conducir automóviles y hubo una tendencia de aumento de la VM con un aumento de la puntuación del MEEM. La VM es un indicador importante que debe ser evaluado en adultos mayores conductores. Por lo tanto, es un tema que deberá ser incluido en las evaluaciones de los centros médicos de evaluación de tránsito, así como también el rastreo cognitivo, fundamental para analizar un conjunto de actividades mentales necesarias para una conducción vehicular segura.


Abstract Objective: To investigate the association between cognition, gait speed and the result of vehicle habilitation of elderly candidates for the National Driver's License. Methods: Quantitative cross-sectional study developed in 12 traffic agencies in Curitiba, state of Paraná, Brazil. The probabilistic sample consisted of 421 elderly people (≥ 60 years). The Mini-Mental State Examination (MMSE), gait speed testing and consultations to forms of the National Qualified Drivers Registration were used for data collection. The relationship between variables was identified through the multiple linear regression test, stepwise method, using the statistical program R, version 3.4.0. Results: When increasing a unit in the MMSE score, the chance of the elderly person being considered as temporarily unfit to drive decreased by 54.96% (95% CI; 28.47% - 92.69%I; p<0.0001). When increasing a unit in the MMSE score, there was an increase in gait speed (GS) of 0.0091 (95% CI: 0.0005 - 0.0174; p=0.0366). Conclusion: The high MMSE score decreased the probability of the elderly participant being considered temporarily unfit to drive motor vehicles. There was a trend of higher GS with the increase in MMSE scores. As GS is an important indicator to be assessed in elderly drivers, this topic should be included in evaluations of traffic agencies, as well as cognitive screening, which is essential to assess a set of mental activities necessary for safe driving.


Subject(s)
Humans , Middle Aged , Aged , Automobile Driver Examination , Automobile Driving , Physical Fitness , Cognition , Walking Speed , Mental Status and Dementia Tests , Cross-Sectional Studies , Evaluation Studies as Topic
13.
Nat Commun ; 11(1): 5860, 2020 11 17.
Article in English | MEDLINE | ID: mdl-33203872

ABSTRACT

Mature oligodendrocytes (MOLs) show transcriptional heterogeneity, the functional consequences of which are unclear. MOL heterogeneity might correlate with the local environment or their interactions with different neuron types. Here, we show that distinct MOL populations have spatial preference in the mammalian central nervous system (CNS). We found that MOL type 2 (MOL2) is enriched in the spinal cord when compared to the brain, while MOL types 5 and 6 (MOL5/6) increase their contribution to the OL lineage with age in all analyzed regions. MOL2 and MOL5/6 also have distinct spatial preference in the spinal cord regions where motor and sensory tracts run. OL progenitor cells (OPCs) are not specified into distinct MOL populations during development, excluding a major contribution of OPC intrinsic mechanisms determining MOL heterogeneity. In disease, MOL2 and MOL5/6 present different susceptibility during the chronic phase following traumatic spinal cord injury. Our results demonstrate that the distinct MOL populations have different spatial preference and different responses to disease.


Subject(s)
Oligodendroglia/cytology , Oligodendroglia/pathology , Spinal Cord Injuries/physiopathology , Animals , Axons/pathology , Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics , Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism , Biomarkers/metabolism , Cell Lineage , Corpus Callosum/cytology , Encephalomyelitis, Autoimmune, Experimental/pathology , Female , Gene Expression Profiling , Mice, Inbred C57BL , Mice, Inbred CBA , Mice, Knockout , Mice, Transgenic , Oligodendroglia/physiology , Single-Cell Analysis , Spinal Cord/cytology
14.
Rev Gaucha Enferm ; 41: e20190370, 2020.
Article in English, Portuguese | MEDLINE | ID: mdl-33237220

ABSTRACT

OBJECTIVE: To analyze the nursing diagnosis NANDA-I - Caregiver Role Strain validation studies. METHODS: Integrative literature review. Research of studies carried out between 2000 and 2018 with the descriptors: caregivers, nursing diagnosis and validation study in the following databases: Web of Science, EBESCOhost, Scielo Brasil and Portugal, LILACS, RCAAP, CAPES, NANDA-I website, and in the bibliographic references of the articles. Articles in Portuguese, English or Spanish were included. RESULTS: The sample consisted of seven validation studies, with heterogeneity in the methodologies used. The populations where the diagnosis was clinically validated focused on caregivers for the elderly and people with chronic illness. The most prevalent defining characteristics were Stress and Apprehension related to the future. CONCLUSIONS: This diagnosis requires further validation studies among different populations in search of greater accuracy and a reduction in the number of defining characteristics, facilitating the use of taxonomy.


Subject(s)
Nursing Diagnosis , Standardized Nursing Terminology , Aged , Brazil , Caregivers , Humans , Validation Studies as Topic
15.
Rev. Rol enferm ; 43(9): 611-618, sept. 2020. ilus, tab
Article in Spanish | IBECS | ID: ibc-194390

ABSTRACT

INTRODUCCIÓN: La pandemia por CO-VID-19 podría estar dejando secuelas de tipo psicológico en la población. Tanto el hecho esperable de una reinfección de ámbito mundial, como la distribución temporal desigual entre países, nos imponen la necesidad de estar preparados y contar con herramientas que tengan la capacidad de medir en el contexto adecuado la respuesta personal ante esta crisis. OBJETIVO: Llevar a cabo la traducción, adaptación transcultural y validación para estudiantes de Grado en Enfermería de España de la "Escala de Medida de las Manifestaciones del Bienestar Psicológico". MÉTODO: La población diana fueron los estudiantes de los cuatro cursos del Grado en Enfermería de la Universidad Católica de Valencia. La recogida de datos se implementó a través de un cuestionario on line dentro del protocolo @student-sONquarentine. La muestra final quedó constituida por 375 estudiantes. RESULTADOS Y CONCLUSIÓN: Se mantiene la estructura factorial de la escala portuguesa. KMO: 0,923; T. de Bartlett: 4552,347 (p =.000) y r de Pearson por factores entre .702 y .861. Por lo que contamos con un instrumento con criterios óptimos de validez de constructo y fiabilidad para la medida del Bienestar Psicológico en estudiantes de Grado en Enfermería en condiciones de aislamiento


INTRODUCTION: The COVID-19 pandemic could be leaving psychological consequences in the population, both the expected fact of a global reinfection, and the unequal temporal distribution between countries, impose on us the need to be prepared and have tools with the ability to measure in the appropriate context the personal response to this crisis. OBJECTIVE: To carry out the translation, cross-cultural adaptation and validation for students of Bachelor of Nursing in Spain of the "Measurement Scale of the Manifestations of Psychological Well-being". METHOD: The target population was the students of the four courses of the Nursing Degree of the Catholic University of Valencia. Data collection was implemented through an online questionnaire within the @studentsONquarentine protocol. The final sample was made up of 375 students. RESULTS AND CONCLUSION: The factorial structure of the Portuguese scale is maintained. KMO: 0.923; Bartlett's T. 4552.347 (p = .000) and Pearson's r by factors between .702 and .861. Therefore, we have an instrument with optimal criteria of construct validity and reliability for the measurement of Psychological Well-being in Nursing Degree students in conditions of isolation


Subject(s)
Humans , Adaptation, Psychological , Burnout, Psychological/diagnosis , Psychometrics/instrumentation , Psychological Tests/statistics & numerical data , Coronavirus Infections/psychology , Quarantine/psychology , Students, Nursing/psychology , Education, Nursing/trends , Cross-Cultural Comparison , Pandemics/statistics & numerical data
16.
Front Microbiol ; 11: 1270, 2020.
Article in English | MEDLINE | ID: mdl-32670225

ABSTRACT

The biofloc system is a relatively new aquaculture technology that offers practical solution to maintain culture water quality by recycling nutrients and improves the health status and resistance of shrimps against microbial infection, yet the mode of action involved remains unclear. This study aimed to unravel the underlying mechanism behind the protective effect of a biofloc system using Litopenaeus vannamei and acute hepatopancreatic necrosis disease (AHPND)-causing Vibrio parahaemolyticus M0904 strain as a host-pathogen model. The results showed that a biofloc system maintained at a C/N ratio of 15, improves the water quality and contributes to the nutrition of cultured animals as bioflocs might serve as an additional protein source. Furthermore, the study demonstrated that the biofloc system enhances the survival of L. vannamei upon challenge with a V. parahaemolyticus AHPND strain. Remarkably, the results highlight that in the biofloc system, AHPND-causing V. parahaemolyticus possibly switch from free-living virulent planktonic phenotype to a non-virulent biofilm phenotype, as demonstrated by a decreased transcription of flagella-related motility genes (flaA, CheR, and fliS), Pir toxin (PirB VP ), and AHPND plasmid genes (ORF14) and increased expression of the phenotype switching marker AlkPhoX gene in both in vitro and in vivo conditions. Taken together, results suggest that biofloc steer phenotype switching, contributing to the decreased virulence of V. parahaemolyticus AHPND strain toward shrimp postlarvae. This information reinforces our understanding about AHPND in a biofloc setting and opens the possibility to combat AHPND not only by trying to eliminate the AHPND-causing V. parahaemolyticus from the system but rather to steer the phenotypic switch.

17.
Rev. gaúch. enferm ; 41: e20190370, 2020. tab, graf
Article in English | LILACS, BDENF - Nursing | ID: biblio-1139133

ABSTRACT

ABSTRACT Objective: To analyze the nursing diagnosis NANDA-I - Caregiver Role Strain validation studies. Methods: Integrative literature review. Research of studies carried out between 2000 and 2018 with the descriptors: caregivers, nursing diagnosis and validation study in the following databases: Web of Science, EBESCOhost, Scielo Brasil and Portugal, LILACS, RCAAP, CAPES, NANDA-I website, and in the bibliographic references of the articles. Articles in Portuguese, English or Spanish were included. Results: The sample consisted of seven validation studies, with heterogeneity in the methodologies used. The populations where the diagnosis was clinically validated focused on caregivers for the elderly and people with chronic illness. The most prevalent defining characteristics were Stress and Apprehension related to the future. Conclusions: This diagnosis requires further validation studies among different populations in search of greater accuracy and a reduction in the number of defining characteristics, facilitating the use of taxonomy.


RESUMEN Objectivo: Analizar los estudios de validación del diagnóstico de enfermería NANDA-I - cansancio del rol de cuidador. Método: Revisión integradora de la literatura. Estudios de investigación llevados a cabo entre 2000 y 2018 con los descriptores: cuidadores, diagnóstico de enfermería y estudio de validación en las bases de datos: Web of Science, EBESCOhost, Scielo Brasil y Portugal, LILACS, RCAAP, CAPES, sítio web de NANDA-I, y en las referencias bibliográficas de los artículos. Se incluyeron artículos en portugués, inglés o español. Resultados: La muestra consistió en siete estudios de validación, se encontró heterogeneidad en las metodologías utilizadas. Las poblaciones donde el diagnóstico fue validado clínicamente se centraron en los cuidadores de ancianos y personas con enfermedades crónicas. Las características definitorias más prevalentes fueron el estrés y la aprensión relacionadas con el futuro. Conclusiones: Este diagnóstico requiere más estudios de validación en diferentes poblaciones con el objetivo de una mayor precisión y una reducción en el número de características definitorias, facilitando el uso de la taxonomía.


RESUMO Objetivo: Analisar os estudos de validação do diagnóstico de enfermagem NANDA-I - Tensão do Papel de Cuidador. Método: Revisão integrativa da literatura. Pesquisa de estudos realizados entre 2000 e 2018 com os descritores: cuidadores, diagnóstico de enfermagem e estudo de validação nas bases de dados: Web of Science, EBESCOhost, Scielo Brasil e Portugal, LILACS, RCAAP, CAPES, site da NANDA-I, e nas, referências bibliográficas dos artigos. Foram incluídos artigos em português, inglês ou espanhol. Resultados: A amostra foi constituída por sete estudos de validação, sendo verificada heterogeneidade nas metodologias utilizadas. As populações onde o diagnóstico foi validado clinicamente centraram-se em cuidadores de idosos e pessoas com doença crónica. As características definidoras mais prevalentes foram o Estresse e a Apreensão relacionada com o futuro. Conclusões: Este diagnóstico necessita outros estudos de validação em diferentes populações visando uma maior acurácia e uma redução do número de características definidoras, facilitando o uso da taxonomia.


Subject(s)
Aged , Humans , Nursing Diagnosis , Standardized Nursing Terminology , Brazil , Caregivers , Validation Studies as Topic
18.
Rev Lat Am Enfermagem ; 27: e3138, 2019 Apr 29.
Article in Portuguese, English, Spanish | MEDLINE | ID: mdl-31038632

ABSTRACT

OBJECTIVE: to analyze the factors associated with gait speed in elderly subjects undergoing physical and mental fitness tests to obtain a driver's license. METHOD: a cross-sectional quantitative study conducted in transit agencies. The probabilistic sample included 421 elderly (≥ 60 years old). The study was developed through application of questionnaires and tests that assess the frailty phenotype. For evaluating gait speed, the time spent by each participant to walk a 4.6 meter distance at normal pace on a flat surface was timed. Data were analyzed by using multiple linear regression and the stepwise method. The R statistical program version 3.4.0 was adopted. RESULTS: there was a significant association between gait speed and paid work (<0.0000), body mass index (<0.0000), Mini-Mental State Examination (=0.0366), physical frailty (pre-frail =0.0063 and non-frail <0.0000), age (<0.0000), sex (=0.0255), and manual grip strength (<0.0000). CONCLUSION: elderly drivers who do not work, women of advanced age, high body mass index, low score in the Mini-Mental State Examination, low hand grip strength, and frail tend to decrease gait speed and should be a priority of interventions.


Subject(s)
Automobile Driver Examination , Frail Elderly , Geriatric Assessment , Walking Speed/physiology , Aged , Aged, 80 and over , Automobile Driver Examination/psychology , Cross-Sectional Studies , Female , Hand Strength/physiology , Humans , Male , Middle Aged
19.
Acta Paul. Enferm. (Online) ; 32(2): 178-185, Mar.-Abr. 2019. tab
Article in Portuguese | LILACS, BDENF - Nursing | ID: biblio-1001045

ABSTRACT

Resumo Objetivo: Identificar a prevalência do diagnóstico de enfermagem ansiedade relacionada à morte da NANDA-I em cuidadores familiares de doentes paliativos; e validar as características definidoras associadas. Métodos: Estudo transversal, exploratório e descritivo utilizando o Modelo de Validação Clínica de Fehring, em uma amostra de 111 cuidadores familiares de doentes paliativos. Foi calculada a sensibilidade, especificidade e valor preditivo das características definidoras. As questões formuladas para operacionalizar as características definidoras foram validadas por um painel de peritos. Resultados: A prevalência do diagnóstico foi de 38,7% na amostra estudada. Foram alvo de validação clínica 17 características definidoras, oito delas emergiram de uma prévia revisão da literatura. Nove características foram classificadas como principais e oito secundárias. Conclusão: O diagnóstico foi validado em cuidadores familiares de doentes paliativos. A validação clínica de novas características definidoras confirmou a necessidade da sua revisão de modo a estar adequado à clínica. A prevalência do diagnóstico na amostra estudada, indica que este é um fenômeno relevante a que os profissionais devem estar particularmente atentos, de modo a implementar intervenções específicas para minimizar a ansiedade relacionada à morte dos cuidadores familiares de doentes paliativos.


Resumen Objetivo: Identificar la prevalencia del diagnóstico de enfermería ansiedad ante la muerte de la NANDA-I en cuidadores familiares de enfermos paliativos y validar las características definitorias asociadas. Métodos: Estudio transversal, exploratorio y descriptivo utilizando el modelo de validación clínica de Fehring, en una muestra de 111 cuidadores familiares de enfermos paliativos. Se calculó la sensibilidad, especificidad y valor predictivo de las características definitorias. Los temas formulados para poner en funcionamiento las características definitorias fueron validados por un grupo de peritos. Resultados: La prevalencia del diagnóstico fue de 38,7% en la muestra estudiada. Fueron objeto de validación clínica 17 características definitorias, 8 de ellas surgieron de una revisión bibliográfica previa. Nueve características se clasificaron como principales y ocho como secundarias. Conclusión: El diagnóstico fue validado en cuidadores familiares de enfermos paliativos. La validación clínica de nuevas características definitorias confirmó la necesidad de su revisión a fin de adecuarse a la clínica. La prevalencia del diagnóstico en la muestra estudiada indica que este es un fenómeno relevante al que los profesionales deben estar especialmente atentos, a fin de implementar intervenciones específicas para minimizar la ansiedad ante la muerte de los cuidadores familiares de enfermos paliativos.


Abstract Objective: To identify the prevalence of the NANDA-I nursing diagnosis of death anxiety among family caregivers of palliative patients and to validate the associated defining characteristics. Methods: This was a cross-sectional, exploratory, and descriptive study using Fehring's clinical diagnostic validity model in a sample of 111 family caregivers of palliative patients. The sensitivity, specificity, and predictive value of the defining characteristics were calculated. Questions formulated to operationalize the defining characteristics were validated by a panel of experts. Results: The prevalence of the diagnosis was 38.7% in the study sample, and 17 defining characteristics were subjected to clinical validation, of which eight emerged from a previous literature review. Of the 17 defining characteristics, nine were classified as primary and eight as secondary. Conclusion: The diagnosis was validated in family caregivers of palliative patients. The clinical validation of new defining characteristics confirmed the need to review these characteristics to ensure their clinical suitability. The prevalence of the diagnosis in the study sample indicates that death anxiety is a relevant phenomenon among family caregivers of palliative patients that professionals should be particularly aware offing order to implement specific interventions to minimize this condition.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Anxiety/psychology , Nursing Diagnosis , Attitude to Death , Critical Illness , Caregivers/psychology , Cross-Sectional Studies
20.
REME rev. min. enferm ; 23: e-1176, jan.2019.
Article in English, Portuguese | LILACS, BDENF - Nursing | ID: biblio-1005456

ABSTRACT

Objetivo: trata-se de estudo transversal cujo objetivo foi analisar a associação entre a condição de fragilidade física e as características clínicas dos idosos submetidos aos exames de aptidão física e mental para conduzir veículos automotores. Método: o estudo foi realizado em 11 clínicas de trânsito no período de agosto de 2015 a março de 2017. A amostra foi constituída por 347 idosos (≥ 60 anos). Destes, 1,5% foi considerado frágil, 46,8% pré-frágeis e 51,7% não frágeis. Quanto às características clínicas 67,4% possuem alguma doença, 66,6% utilizam medicamento(s), 4,9% usam cinco ou mais medicamentos, 21,6% ingerem bebidas alcoólicas, 9,8% fazem uso de tabaco, 9,2% sofreram queda(s) e 9,8% foram hospitalizados. Resultados: não houve associação significativa entre as características clínicas e a condição de fragilidade física dos idosos. A condição de pré-fragilidade apresentou alto percentual, o que reforça a necessidade do rastreamento da fragilidade física em idosos nas clínicas de trânsito. Conclusão: o estudo é inédito na área da Enfermagem e os resultados fornecem subsídios para outros estudos que objetivam um trânsito mais seguro.(AU)


Objective: this is a cross-sectional study whose objective was to analyze the association between the condition of physical frailty and clinical characteristics of elderly people undergoing physical and mental fitness examination for driving licensing of motor vehicles. Method: the study was carried out in 11 clinics specialized in traffic, from August 2015 to March 2017. The sample consisted of 347 elderly (≥ 60 years old). Of these, 1.5% elderly were considered frail, 46.8% pre-frail, and 51.7% non-frail. Regarding clinical characteristics, 67.4% had a disease, 66.6% used medication(s), 4.9% made use of five or more medicines, 21.6% drank alcohol, 9.8% used tobacco, 9.2% had suffered falls, and 9.8% had been hospitalized. Results: there was no significant association between the clinical characteristics and the condition of physical frailty in the elderly. Pre-frailty presented a high percentage, which reinforces the need to track physical frailty in elderly people in clinics specialized in traffic. Conclusion: the study is unprecedented in the area of Nursing and the results provide subsidies for further studies aimed at a safer traffic.(AU)


Objetivo: estudio transversal con el objetivo de analizar la asociación entre la condición de fragilidad física y las características clínicas de las personas mayores obligadas a realizar las pruebas de aptitud física y mental para conducir vehículos automotores. Método: el estudio fue realizado en 11 clínicas de tránsito entre agosto de 2015 y marzo de 2017. Resultados y discusión: la muestra estaba compuesta de 347 adultos mayores (≥ 60 anos). El 1,5% era considerado frágil, 46,8% pre-frágil y un 51,7% no frágil. Sobre...(AU)


Subject(s)
Humans , Male , Female , Aged , Automobile Driver Examination , Automobile Driving , Population Characteristics , Frail Elderly , Health of the Elderly
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