1.
J Med Chem
; 47(26): 6447-50, 2004 Dec 16.
Article
in English
| MEDLINE
| ID: mdl-15588077
ABSTRACT
We describe the development of cell-permeable beta-secretase inhibitors that demonstratively inhibit the production of the secreted amino terminal fragment of an artificial amyloid precursor protein in cell culture. In addition to potent inhibition in a cell-based assay (IC50 < 100 nM), these inhibitors display impressive selectivity against other biologically relevant aspartyl proteases.