[Recurrent adenocarcinoma of the uterus]. / Recidivni adenokarcinom korpusa uterusa.

In a 60-year-old woman because of postmenopausal haemorrhage diagnostic curettage was performed. The histopathologic finding was the adenocarcinoma of the endometrium. The clinical stage was Ib, grade 2 or respectively presumptive stage IV with regard to ultrasound and radiographic findings. After radical hysterectomy and the resection of the sigmoid colon, chemotherapy with cytostatics was applied for 6 months. Three months after chemotherapy the recurrence of the tumour in the vaginal formix and superficial inguinal lymph nodes metastases appeared. Colpectomy with the extirpation of vaginal carcinoma and inguinal lymphadenectomy were performed, followed by irradiation. The course of the disease has shown that when the cancer is located near the point of entry of the uterine tube, the diagnosis and, if needed, therapy should be extended to inguinal regions too.

[Benign mesenchymal tumors of the uterus]. / O benignim mezenhimnim tumorima uterusa.

Benign mesenchymal tumours of the uterus are discussed. The results are compared with those of other authors and respective epidemiological findings are put forward. Clinical and histological characteristics of uterine myomas and adenomyomas are described in more detail. Irregular bleeding is most frequent among clinical symptoms; it is caused by the persistence of the proliferative endometrium. The secretory conversion of the ectopic endometrium in adenomyoma appears in the glandular epithelium only, while the stromal response to progesteron activity seems inadequate. Maturation of the ectopic and the uterine endometrium is discordant. The cause is the retardation of both the proliferative and secretory phases in the ectopic endometrium. After secretory conversion of the ectopic endometrium the exhaustion and destruction of glands appears. The regeneration of the ectopic endometrium fails to occur because of the absence of the basal layer in the ectopic endometrium. Therefore the authors suppose that the regression of the ectopic endometrium in adenomyomas might be the result of ovulatory cycles.