1.
Eur J Med Chem
; 44(5): 1997-2001, 2009 May.
Article
in English
| MEDLINE
| ID: mdl-19008020
ABSTRACT
It has been found that selective N1-alkylation of 3,4-dihydropyrimidine-2(1H)-ones can be achieved under solvent-less, mild phase transfer catalytic (PTC) conditions with tetrabutylammonium hydrogen sulfate and 50% aqueous NaOH as the catalyst and base, respectively. The procedure is tolerant to substitutional variation at key diversity points on the pyrimidinone moiety.