ABSTRACT
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare type of non-Hodgkin T-cell lymphoma, recently defined in the 2016 World Health Organization (WHO) classification of lymphoid neoplasms. It occurs more commonly when textured implants are used and appears clinically as a late seroma. Cytologically, these lesions are composed of large atypical cells with pleomorphic nucleus and an immunophenotype positive for T cell markers and CD30, and negative for ALK1. We report a 56-years-old woman with breast implants who developed a periprosthetic seroma three years after surgery. A fine needle aspiration of the lesion was carried out. Cytology and the immunocytochemical study revealed cells compatible with BIA-ALCL. The flow cytometric study was negative. Excisional biopsy of the capsule was performed, observing that the neoplastic cells were confined to the inner surface of the capsule. Imaging studies did not find evidence of disseminated disease. The present case demonstrates the importance of the study of any late periprosthetic effusion, which can be performed using fine needle aspiration.
Subject(s)
Female , Humans , Middle Aged , Breast Neoplasms , Lymphoma, Large-Cell, Anaplastic , Breast Implants , Breast Implantation , Breast Neoplasms/surgery , Lymphoma, Large-Cell, Anaplastic/surgery , Lymphoma, Large-Cell, Anaplastic/diagnosis , Lymphoma, Large-Cell, Anaplastic/etiology , Breast Implants/adverse effects , Breast Implantation/adverse effects , Biopsy, Fine-Needle , Seroma/etiologyABSTRACT
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare type of non-Hodgkin T-cell lymphoma, recently defined in the 2016 World Health Organization (WHO) classification of lymphoid neoplasms. It occurs more commonly when textured implants are used and appears clinically as a late seroma. Cytologically, these lesions are composed of large atypical cells with pleomorphic nucleus and an immunophenotype positive for T cell markers and CD30, and negative for ALK1. We report a 56-years-old woman with breast implants who developed a periprosthetic seroma three years after surgery. A fine needle aspiration of the lesion was carried out. Cytology and the immunocytochemical study revealed cells compatible with BIA-ALCL. The flow cytometric study was negative. Excisional biopsy of the capsule was performed, observing that the neoplastic cells were confined to the inner surface of the capsule. Imaging studies did not find evidence of disseminated disease. The present case demonstrates the importance of the study of any late periprosthetic effusion, which can be performed using fine needle aspiration.
Subject(s)
Breast Implantation , Breast Implants , Breast Neoplasms , Lymphoma, Large-Cell, Anaplastic , Biopsy, Fine-Needle , Breast Implantation/adverse effects , Breast Implants/adverse effects , Breast Neoplasms/surgery , Female , Humans , Lymphoma, Large-Cell, Anaplastic/diagnosis , Lymphoma, Large-Cell, Anaplastic/etiology , Lymphoma, Large-Cell, Anaplastic/surgery , Middle Aged , Seroma/etiologyABSTRACT
Se realizó un estudio retrospectivo en 174 pacientes con diagnóstico confirmado por patología por tumor renal, desde enero de 1983 hasta mayo de 1992. Ciento diez pacientes (63,8 por ciento) presentaron sintomatología del tumor renal y 64 pacientes (36,2 por ciento) fueron considerados como hallazgo incidental.La Ecotomografía abdominal tuvo la mayor sensibilidad para el diagnóstico (84,6 por ciento) y la Tomografía Axial Computada (15,4 por ciento). En hallazgos clínicos objetivados más importantes fueron la hematuria y el dolor lumbar, la triada clásica de Guyón se encontró en el (2,8 por ciento) de los pacientes. En el 44,2 por ciento de los pacientes no se encontró alteraciones de laboratorio producidas por el tumor renal. Haciendo una relación entre hallazgo incidental y estadificación, el (49,9 por ciento) estuvieron en estadío I-II y el (10,9 por ciento) en estadío IV
