ABSTRACT
Cloprostenol, a synthetic derivative of prostaglandin F2α, effectively triggers functional and morphological regression of the corpus luteum (luteolysis). In rural Peru, the guinea pig (Cavia porcellus) holds significance within the local economy and serves as a valuable protein source. Enhancing reproductive efficiency is crucial to achieve uniformity in weight, age, and litter size across commercial systems. Thus, our study aimed to evaluate the effect of cloprostenol with and without male stimulation on the onset, duration, and intensity of oestrus in Peru guinea pigs. A total of 128 guinea pigs (120 females and eight males) between 8 and 12 months of age, weighing between 800 and 1200 g, were distributed in cages of 15 females per treatment. Cloprostenol sodium (0 [control], 0.20, 0.25, and 0.30 mg/animal) was IM administered to the groups with and without male stimulation. Four isolated males in individual cages, different from the one used for the treatment, were considered to detect oestrus. The oestrus intensity was assessed by observing sexual behaviour signs such as restlessness, moaning, attempts to mount, pelvic elevation, loin stretching, and vulvar inflammation. The oestrus was manifested 2 days after the administration of cloprostenol sodium. At a dose of 0.30 mg/animal and with male stimulation, the earliest oestrus was observed at 46.9 h. There was a reduction in the oestrus duration (p < .05) in guinea pigs that received the three doses of cloprostenol sodium compared to the control group. The highest percentages of frank oestrus intensity (66.7%) were strongly associated with the administered doses of cloprostenol sodium (p < .01). In conclusion, the cloprostenol sodium administration was proper for rapid oestrus induction in Peru guinea pigs.
Subject(s)
Cloprostenol , Estrus Synchronization , Animals , Guinea Pigs , Male , Female , Cloprostenol/pharmacology , Cloprostenol/administration & dosage , Estrus Synchronization/drug effects , Sexual Behavior, Animal/drug effects , Estrus/drug effects , PeruABSTRACT
Nos propusimos conocer la utilidad que se le ha dado al colgajo radial micro quirúrgico en la reconstrucción de cabeza y cuello, en el Servicio de Cirugía Plástica del Instituto Nacional de Enfermedades Neoplásicas (INEN) de Lima û Perú, desde su aplicación en el año 1997 hasta el 2006; así como determinar la tasa de éxito, y las complicaciones más frecuentes. Se realizó un estudio no experimental, descriptivo, longitudinal y retrospectivo, revisándose las historias clínicas de todos los pacientes que fueron sometidos a esta reconstrucción. Se encontraron 25 casos, (11 varones, con promedio de edad: 43a; y 14 mujeres, prom. de edad: 42a). La neoplasia se localizó en: lengua (n=18; 72%), mucosa oral de mejilla: (n=3; 12%), piso de boca (n=2; 8%), encía y piel nasolabial (1 caso cada uno). El tipo histológico de cáncer fue en todos carcinoma epidermoide infiltrante (100%). La cirugía realizada fue: hemiglosectomía + reconstrucción (n=10); glosectomía subtotal + reconstrucción (n=9); resección local amplia + reconstrucción (n=6). En 13 pacientes (52%) no hubo ninguna complicación de la zona donante, en el resto hubo algún grado de pérdida parcial del injerto, con cicatrización hipertrófica posterior en 7 pacientes (28%). En cuanto a complicaciones de la zona reconstruida, en 19 pacientes (76%) no hubo complicaciones; en 3 casos (12%) se tuvo que retirar el colgajo por trombosis de la anastomosis microvascular y desarrollaron fístula orocervical; 2 pacientes, (8%) desarrollaron dehiscencia parcial, que mejoro con manejo conservador. La tasa de éxito el colgajo fue: 88%.
We have undertaken to ascertain the utility has given radial micro surgical flap in reconstruction of head and neck, in Plastic Surgery Service of the National Institute of Neoplastic Diseases (INEN) from Lima - Peru, since its implementation in 1997 until 2006, and to determine the success rate and complications more frequent. We performed a non-experimental, descriptive, longitudinal and retrospective study, reviewing the medical records of all patients who underwent this reconstruction. We found 25 cases (11 males, mean age: 43y, and 14 women, means age: 42y). The neoplasm was located in: tongue (n = 18; 72%), oral mucosa cheek (n = 3, 12%), floor of mouth (n = 2, 8%), gum and nasolabial skin (1 case each one). The histological type of cancer was in all invasive squamous cell carcinoma (100%). Surgery performed was: hemiglossectomy + reconstruction (n = 10), subtotal glossectomy + reconstruction (n = 9), wide local resection + reconstruction (n = 6). In 13 patients (52%) there were no complications in the donor area, the rest had some degree of partial loss of the graft, with subsequent hypertrophic scarring in 7 patients (28%). As for complications in the reconstructed area, in 19 patients (76%) there were no complications; in 3 cases (12%) had to remove the flap by thrombosis of microvascular anastomoses and developed orocervical fistulae; two patients (8% ) developed partial dehiscence, which improved with conservative management. The flap success rate was 88%.
