[The effect of new synthetic prostanoids on the aggregation activity of human thrombocytes]. / Vliianie novykh sinteticheskikh prostanoidov na agregatsionnuiu aktivnost' trombotsitov cheloveka.

We found that a number of new synthetic prostanoids caused a prominent reduction of human platelet aggregation in the in vitro experiments. Moreover, two of this agents, IOS 3933 and IOS 4732, gives storage stability. Hemoxygenase activity, metabolic homeostasis of bilirubin in brain and transport function of serum albumin in animals receiving cobalt chloride.

[The effect of new synthetic prostanoids on the indices of the blood coagulation system]. / Vliianie novykh sinteticheskikh prostanoidov na nekotorye pokazateli svertyvaiushchei sistemy krovi.

In the experiments on rabbits it was shown, that the administration of prostanoids IOS 3933 caused a reduction of ADP- and collagen induced platelet aggregation, platelet adhesion to collagen and elevation of t-PA level. This prostanoid prevented both a decrease in platelet count and reduction of AT III activity, but did not affect the protein C level during thromboplastin infusion.