Subject(s)
Respiratory Mucosa/pathology , Tuberculosis, Pulmonary/diagnostic imaging , Tuberculosis, Pulmonary/pathology , Antitubercular Agents/therapeutic use , Bronchoscopy , Cephalosporins/therapeutic use , Child , Female , Humans , Pneumonia/diagnosis , Pneumonia/pathology , Radiography , Severity of Illness Index , Tuberculosis, Pulmonary/drug therapyABSTRACT
The activities of two federal and regional tuberculosis sanatoriums for children and adolescents were analyzed. The clinical characteristics and the results of the examination and treatment were studied in 510 patients aged 12-17 years who had various manifestations of tuberculous infection. The beds in the sanatoriums were ascertained to occupy irrationally: the proportion of patients with local forms of tuberculosis there is not more than 30%. Guidelines for selection of children and adolescents with tuberculosis from risk groups and for detection of the disease were developed. A proposal was made to set up consultative and diagnostic centers at the sanatorium basis. The paper shows it possible and expedient to treat children and adolescents with new-onset local, non-destructive forms of tuberculosis under the conditions of a sanatorium.
Subject(s)
Delivery of Health Care/organization & administration , Health Resorts , Tuberculosis, Pulmonary/therapy , Adolescent , Child , Health Resorts/statistics & numerical data , Humans , Retrospective Studies , Russia/epidemiology , Socioeconomic Factors , Tuberculosis, Pulmonary/epidemiologyABSTRACT
Main component of biologically active additive to food on the basis of sea alga Laminaria of which are copper derivatives of a chlorophyll. Application of this biologically active to food in complex with tuberculosis chemotherapy of 48 adolescents (14-17 years old) at a sanatorium stage of treatment was investigated. The comparison group were 30 patients, receiving chemotherapy without utilize of biologically active to food. It is established, that mentioned biologically active additive to food promotes favorable radiological dynamic of process, improvement of functional activity T-lymphocites and the contents of substances of low and average molecular weight and malonic dialdehyde in plasma.
Subject(s)
Food Additives/therapeutic use , Laminaria/chemistry , Tuberculosis, Pulmonary/diet therapy , Adolescent , Antioxidants/analysis , Antioxidants/pharmacology , Health Resorts , Humans , Lipid Peroxidation/drug effects , Malondialdehyde/blood , T-Lymphocytes/drug effects , T-Lymphocytes/immunology , Tuberculosis, Pulmonary/immunology , Tuberculosis, Pulmonary/pathology , Tuberculosis, Pulmonary/therapyABSTRACT
Antituberculosis antibodies were detected in 164 children and adolescents who had tuberculosis and who were infected with mycobacteria. The diagnostic value of indirect hamagglutination tests with phosphatide antigen and tuberculin, complement uptake, passive hemolysis, and enzyme immunoassay for evaluating the progression of tuberculosis was defined in patients at a specialized sanatorium. The significance of the tests increases when they are concurrently used.
Subject(s)
Antibodies, Bacterial/analysis , Mycobacterium tuberculosis/immunology , Tuberculosis/immunology , Adolescent , Child , Enzyme-Linked Immunosorbent Assay , Health Resorts , Hemagglutination , Humans , Tuberculin/analysis , Tuberculin Test , Tuberculosis/diagnosisABSTRACT
Medium-weight molecules (MWM) were measured in the plasma of 67 children and adolescents aged 11 to 17 years who were infected with and suffered from various types of tuberculosis. The highest values of MWM were found in patients with tuberculous exudative pleuritis and infiltrative pulmonary tuberculosis. During treatment, there was a significant reduction in the mean levels of MWM in 20 follow-up patients. It is concluded that it is expedient to employ this test to detect insidious tuberculosis activity during sanatorium treatment and to use it as a criterion for therapeutical efficiency.
Subject(s)
Health Resorts , Peptides/blood , Tuberculosis, Pulmonary/blood , Adolescent , Child , Female , Humans , Male , Molecular Weight , Spectrophotometry, Ultraviolet , Tuberculosis, Lymph Node/blood , Tuberculosis, Lymph Node/diagnosis , Tuberculosis, Lymph Node/rehabilitation , Tuberculosis, Pleural/blood , Tuberculosis, Pleural/diagnosis , Tuberculosis, Pleural/rehabilitation , Tuberculosis, Pulmonary/diagnosis , Tuberculosis, Pulmonary/rehabilitationABSTRACT
Methods of detection of tuberculous infection in 127 children and adolescents treated in special hospitals and sanatoria have seen analyzed. The diagnosis was made using tuberculin in 62.2%, epidemiological evidence in 12.6%, fluorographic findings in 7.8%, survey of risk groups in 7.1%. 10.2% of the patients sought medical advice. A favourable course of the disease was seen in cases detected at tuberculin diagnosis and risk group examination. Complications occurred primarily in those who sought medical advice.
Subject(s)
Tuberculosis/diagnosis , Adolescent , Age Factors , Child , Child, Preschool , Fluoroscopy , Humans , Infant , Infant, Newborn , Russia/epidemiology , Tuberculin Test , Tuberculosis/diagnostic imaging , Tuberculosis/epidemiologyABSTRACT
The paper deals with improvement of pulmonary mycobacterioses treatment. In the preliminary experiments with the use of an experimental model, 32 regimens of M. avium mycobacteriosis treatment were tested on 872 white mice and the most efficient one was chosen, which comprised a combination of kanamycin-ethambutol-thionamide coupled with sulfadimethoxine and thymalin courses. The clinical course and results of treatment of 43 patients (23 of the main and 20 of the control group) with fibro-cavernous pulmonary mycobacteriosis were studied. Employment of the new treatment regimen significantly enhanced its efficiency--the incidence of bacillary excretion cessation increased from 30 to 82.6%.
